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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/抗α-突触核蛋白[3H9]/M-1402-100/100µg的小鼠单克隆抗体
商品详细Biosensis/抗α-突触核蛋白[3H9]/M-1402-100/100µg的小鼠单克隆抗体
Biosensis/抗α-突触核蛋白[3H9]/M-1402-100/100µg的小鼠单克隆抗体
Biosensis/抗α-突触核蛋白[3H9]/M-1402-100/100µg的小鼠单克隆抗体
商品编号: M-1402-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionAlphasynucleinisanabundant140aminoacidneuronalprotein,expressedprimarilyatpresynapticterminalsinthecentralnervoussystem.FUNCTION:Maybeinvolvedintheregulationofdopaminereleaseandtransport.Solubleprotein,normallylocalizedprimarilyatthepresynapticregionofaxons,whichcanformfilamentousaggregatesthatarethemajornonamyloidcomponentofintracellularinclusionsinseveralneurodegenerativediseases(synucleinopathies).Inducesfibrillizationofmicrotubule-associatedproteintau.Reducesneuronalresponsivenesstovariousapoptoticstimuli,leADIngtoadecreasedcaspase3activation.TISSUESPECIFICITY:Expressedprincipallyinbrainbutisalsoexpressedinlowconcentrationsinalltissuesexaminedexceptinliver.Concentratedinpresynapticnerveterminals.SUBUNIT:Solublemonomerwhichcanformfilamentousaggregates.InteractswithUCHL1.InteractswithphospholipaseDandhistones.SUBCELLULARLOCATION:Cytoplasm.Membrane.Nucleus.Note=Membrane-boundindopaminergicneurons.Alsofoundinthenucleus.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.
BatchNo.Seeproductlabel
Unitsize100µg
AntigenRecombinantfulllengthhumanalphasynucleinexpressedandpurifiedfromE.coli
AntigenLocationMultiplesubcellularlocationsreportedaswellassecretedextracellularlyincertainconditions.
AntibodyTypeMonoclonal
IsotypeIgG1
Clone3H9
OtherNamesNon-AbetacomponentofADamyloid;Non-A4componentofamyloidprecursor;NACP
AccessionP37840SYUA_HUMAN;
ProducedinMouse
MolecularWeight14-15kDa,reducedPAGEpreparations
PurityProteinGpurifiedmouseIgG
ApplicationsWesternBlotting(WB)andImmunocytochemistry(IC/IF).Adilutionof1:1,000-1:5,000isrecommendedforWB.Adilutionof1:500-3,000isrecommendedforIC/IF.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThespecificityofthisantibodyhasbeenconfirmedbyWB.Thisantibodydetects~14-15kDaalphasynucleinprotein.Theepitopefor3H9isintheregion61-95whichcorrespondtothe“Non-AmyloidbetaComponentofAlzheimer’sdiseaseamyloid”(NAC)region.3H9willalsobindhumanalpha-synucleincontainingtheA30PandA53Tmutations.
Cross-reactivityHuman,horse,cow,pig,chicken,rat,mouse.Predictedtoreactwithothermammaliantissuebecauseofhighlyconservednatureoftheprotein.
BlastURLClickhere
FormLyophilized,fromPBSwith5%trehaloseand0.05%sodiumazide.
AppearanceWhitepowder
ReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.Finalbuffercontains0.05%sodiumazideasapreservative
StorageAfterreconstitutionoflyophilizedantibody,divideintosingleusealiquotsandstoreat-20-80°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
MSDSClick to download the Material Safety Data SheetMSDS_M-1402-100_as_at_July2015.pdf
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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