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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Mouse monoclonal antibody to Microtubule-associated protein tau/M-1703-100/100 uL
商品详细Biosensis/Mouse monoclonal antibody to Microtubule-associated protein tau/M-1703-100/100 uL
Biosensis/Mouse monoclonal antibody to Microtubule-associated protein tau/M-1703-100/100 uL
Biosensis/Mouse monoclonal antibody to Microtubule-associated protein tau/M-1703-100/100 uL
商品编号: M-1703-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:PromotesmicrotubuleassemblyandstABIlity,andmightbeinvolvedintheestablishmentandmaintenanceofneuronalpolarity.TheC-terminusbindsaxonalmicrotubuleswhiletheN-terminusbindsneuralplasmamembranecomponents,suggestingthattaufunctionsasalinkerproteinbetweenboth.Axonalpolarityispredeterminedbytaulocalization(intheneuronalcell)inthedomainofthecellbodydefinedbythecentrosome.TheshortisoformsallowplasticityoftheCytoskeletonwhereasthelongerisoformsmaypreferentiallyplayaroleinitsstabilization. SUBCELLULARLOCATION:Cytoplasm;cytosol.Cellmembrane.Mostlyfoundintheaxonsofneurons,inthecytosolandinassociationwithplasmamembranecomponents.ALTERNATIVEPRODUCTS:8namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.Isoformsdifferfromeachotherbythepresenceorabsenceofupto5ofthe15exons.Oneoftheseoptionalexonscontainstheadditionaltau/MAPrepeat.TISSUESPECIFICITY:Expressedinneurons.IsoformPNS-tauisexpressedintheperipheralnervoussystemwhiletheothersareexpressedinthecentralnervoussystem.DEVELOPMENTALSTAGE:Four-repeat(typeII)tauisexpressedinanadult-specificmannerandisnotfoundinfetalbrain,whereasthree-repeat(typeI)tauisfoundinbothadultandfetalbrain.DOMAIN:Thetau/MAPrepeatbindstotubulin.InAlzheimerdisease,theneuronalcytoskeletoninthebrainisprogressivelydisruptedandreplacedbytanglesofpairedhelicalfilaments andstraightfilaments,mainlycomposedofhyperphosphorylatedformsofMicrotubule-associatedproteinTau.DefectsinMicrotubule-associatedproteinTauareacauseoffrontotemporaldementiaandparkinsonismlinkedtochromosome17,aswellasanumberofotherneurodegenerativediseases.
BatchNo.Seeviallabel
Unitsize100uL
AntigenRecombinantfulllengthversionoftheshortesthumantauisoformpurifiedfromE.coli.
AntibodyTypeMonoclonal
IsotypeIgG1
OtherNamesNeurofibrillarytangleprotein;Pairedhelicalfilament-tau;PHF-tau;MAPT;MTBT1;TAU
ProducedinMouse
ApplicationsWesternBlotting(WB)andImmunocytochemistry(ICC).Adilutionof1:5,000-1:10,000isrecommendedforWB.Adilutionof1:500-1,000isrecommendedforICC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityTheantibodyreactswithmultiplecloselyspacedbandscoveringtheregionoftheblotfrom48kDato67kDa.Ithasalsobeenusedsuccessfullyforimmunocytochemistry.
SpeciesAgainstHuman,ratandmouse.Itisexpectedthatitwillworkonothermammaltissues.
FormLyophilisedpurifiedculturesupernatantwith5%trehaloseand0.5%sodiumazide.
AppearanceWhitepowder
ReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.
StorageMaintainlyophilizedmaterialat2-8°C.Afterreconstitutionoflyophilizedantibody,aliquotandstoreat-20°Cforahigherstability.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
GeneralReferences1.SkeneJH,WillardM.Changesinaxonallytransportedproteinsduringaxonregenerationintoadretinalganglioncells.J.CellBiol.89:86-95(1981).
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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