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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/抗泛素[Ubi-1]/M-1404-100/100µl的小鼠单克隆抗体
商品详细Biosensis/抗泛素[Ubi-1]/M-1404-100/100µl的小鼠单克隆抗体
Biosensis/抗泛素[Ubi-1]/M-1404-100/100µl的小鼠单克隆抗体
Biosensis/抗泛素[Ubi-1]/M-1404-100/100µl的小鼠单克隆抗体
商品编号: M-1404-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionUbiquitinisahighlyconserved76aminoacidproteinwithanestimatedmolecularweightof8.56kDawhichhasacentralroleinregulatedproteindegradation.Itisaproteinmodifierwhichcanbecovalentlyattachedtotargetlysineseitherasamonomerorasalysine-linkedpolymer.Severaltypesofpolymericchainscanbeformeddependingonthelysineusedfortheassembly.Attachmenttoproteinsasapolymerleadstotheirdegradationbythe26Sproteosome;acomplex,multicatalyticcytosolicandnuclearprotease.Attachmenttoproteinsasamonomerorasanalternativelylinkedpolymerdoesnotleadtoproteasomaldegradationandmayberequiredfornumerousfunctions,includingmaintenanceofchromaticstructure,regulationofgeneexpression,stressresponse,ribosomebiogenesisandDNArepair.Ubiquitinissynthesizedasapolyubiquitinprecursorwithexactheadtotailrepeats,thenumberofrepeatsofwhichdifferbetweenspeciesandstrains.Insomespeciesthereisafinalamino-acidafterthelastrepeat,hereinbovineaCys.Someubiquitingenescontainasinglecopyofubiquitinfusedtoaribosomalprotein(eitherL40orS27a).
BatchNo.Seeproductlabel
Unitsize100µl
AntigenRaisedagainstpurifiedubiquitinconjugatedwithglutaraldehydetokeyholelimpethemocyanin.
AntibodyTypeMonoclonal
IsotypeIgG1
CloneUbi-1
OtherNamesRPS27A;UBA52;UBB;UBC;Polyubiquitin-B;Polyubiquitin-C;
AccessionP0CG47UBB_HUMAN;
ProducedinMouse
ApplicationsWesternBlotting(WB),Immunohistochemistry-paraffinembeddedtissue(IH-P)andELISA.SuggesteddilutionforWBis1:500-1,000.ThisantibodycanbeusedonmildlyfixedhistologicalsectionsofhumanbrainforstudiesofAlzheimer'sdisease.Thisantibodyalsoworksonparaffinembeddedmaterial.ItalsorecognisesotherubiquinatedinclusionbodiessuchasLewybodiesofParkinson'sdiseaseandthePickbodiesinPick'sdiseaseinformalinfixedtissues.SuggesteddilutionforIHis1:500.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThespecificityofthisantibodyhasbeenconfirmedbyWB.Thisantibodydetects~8.5kDaUbiquitin.
AntibodyAgainstUbiquitin
Cross-reactivityHu,Bov,Chk,Drosophila,andC.elegans
BlastURLClickhere
FormLyophilisedwith5%trehalose
AppearanceWhitepowder
ReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferences1.JosephsK.A.etal(2006)Atypicalprogressivesupranuclearpalsywithcorticospinaltractdegeneration.JNeuropatholExpNeurol.2006Apr;65(4):396-405.
2.JosephsK.A.etal(2007)Neuropathologicfeaturesoffrontotemporallobardegenerationwithubiquitin-positiveinclusionswithprogranulingene(PGRN)mutations.JNeuropatholExpNeurol.2007Feb;66(2):142-51.
3.RudzinskiL.A.etal(2008)EarlyonsetfamilialAlzheimerDiseasewithspasticparaparesis,dysarthria,andseizuresandN135SmutationinPSEN1.AlzheimerDisAssocDisord.2008Jul-Sep;22(3):299-307.
4.JosephsK.A.etal(2009)EvaluationofsubcorticalpathologyandclinicalcorrelationsinFTLD-Usubtypes.ActaNeuropathol.2009Sep;118(3):349-58.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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