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当前位置: 首页 > 产品中心 > Functional_antibody > 抗Visin样蛋白1/M-1657-100/1 Ea的Biosensis/小鼠单克隆抗体
商品详细抗Visin样蛋白1/M-1657-100/1 Ea的Biosensis/小鼠单克隆抗体
抗Visin样蛋白1/M-1657-100/1 Ea的Biosensis/小鼠单克隆抗体
抗Visin样蛋白1/M-1657-100/1 Ea的Biosensis/小鼠单克隆抗体
商品编号: M-1657-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionVisinin(sometimesknownashippocalcin-likeprotein3,HLP3,HPCAL3,HUVISL1,VLP-1,VILIPandVILIP-1)wasoriginallyisolatedbiochemicallyfromchickenretinaasamajorproteinofabout24kDaonSDS-PAGE(1).Followingcloningandsequencingofvisinin,severalvisininlikeproteinswerediscoveredbyhomologyscreening(2,3).Oneofthese,Visinin-likeprotein1isasmallCalciumbindingproteinwhichisveryabundantinthenervoussystemandisfoundonlyinneurons,thoughdifferentneuronshavedifferentlevelsofexpression(4,5).ItisparticularlyconcentratedincerebellarPurkinjecells,andtendstobemostabundantinperikaryaanddendrites.TheproteinbelongstothelargesuperfamlyofcalmodulinandparavalbumintypeproteinswhichfunctionbybindingCalciumions.Calciumbindingalterstheconfomationoftheseproteinsandallowthemtointeractwithotherbindingpartners,thepropertiesofwhichtheymayalter.Visinin-likeprotein1hasfour"EFhand"domains,whicharenegativelychargedhelix-turn-helixpeptideswhichareresponsIBLeforCalciumbinding.Visinin-likeprotein1is191aminoacidsinsizeandhasamolecularweightonSDS-PAGEof22kDa.TheproteinhasrecentlybeensuggestedtobeausefulbioMarkerofAlzheimer"sdiseaseandtraumaticbraininjury(6,7,8).
AntigenRecombinantVisinin-likeprotein1expressedandpurifiedfromE.coli.
AntibodyTypeMonoclonal
IsotypeIgG1
OtherNamesHippocalcin-likeprotein3,HLP3,HPCAL3,HUVISL1,VLP-1,VILIPandVILIP-1
ProducedinMouse
ApplicationsWesternBlotting(WB)andImmunocytochemistry(IC).Adilutionof1:1,000-1:2,000isrecommendedforWB.Adilutionof1:500-1:1,000isrecommendedforIC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityTheantibodyreactswitha22kDabandbyWesternblotonbovinecerebellumlysate.Ithasalsobeenusedsuccessfullyforimmunocytochemistry.
SpeciesAgainstHuman,bovine,ratandmouse.Itisexpectedthatitwillworkonothermammaltissues.
AntibodyAgainstVisinin-likeprotein1
FormLyophilisedfromPBS.Contains5%trehalose.
AppearanceWhitepowder
ReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
GeneralReferences1.HatakenakaS,KuoCH,MikiN.Analysisofadistinctiveproteininchickretinaduringdevelopment.BrainRes.312:155-63(1983).2.KunoT,KajimotoY,HashimotoT,MukaiH,ShiraiY,SahekiS,TanakaC.CDNAcloningofaneuralvisinin-likeCa(2+)-bindingprotein.BiochemBiophysResCommun.184:1219-25(1992).3.PolymeropoulosMH,IdeS,SoaresMB,LennonGG.SequencecharacterizationandgeneticmappingofthehumanVSNL1gene,ahomologueoftheratvisinin-likepeptideRNVP1.Genomics.29:273-5(1995).4.BernsteinHG,BaumannB,DanosP,DiekmannS,BogertsB,GundelfingerED,BraunewellKH.Regionalandcellulardistributionofneuralvisinin-likeproteinimmunoreactivities(VILIP-1andVILIP-3)inhumanbrain.JNeurocytol.28:655-62(1999).5.PaterliniM,RevillaV,GrantAL,WisdenWExpressionoftheneuronalcalciumsensorproteinfamilyintheratbrain..Neuroscience.99:205-16(2000)6.LaterzaOF,ModurVR,CrimminsDL,OlanderJV,LandtY,LeeJM,LadensonJH.Identificationofnovelbrainbiomarkers.Clin.Chem.9:1713-21(2006)7.LeeJM,BlennowK,AndreasenN,LaterzaO,ModurV,OlanderJ,GaoF,OhlendorfM,LadensonJH.ThebraininjurybiomarkerVLP-1isincreasedinthecerebrospinalfluidofAlzheimerdiseasepatients.Clin.Chem.10:1617-23(2008).8.TarawnehR,D"AngeloG,MacyE,XiongC,CarterD,CairnsNJ,FaganAM,HeadD,MintunMA,LadensonJH,LeeJM,MorrisJC,HoltzmanDM.Visinin-likeprotein-1:diagnosticandprognosticbiomarkerinAlzheimerdisease.AnnNeurol.70:274-85(2011)doi:10.1002/ana.22448.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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