抗Visin样蛋白1/M-1657-100/1 Ea的Biosensis/小鼠单克隆抗体
商品编号:
M-1657-100
品牌:
Biosensis inc
市场价:
¥5940.00
美元价:
3564.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | Visinin(sometimesknownashippocalcin-likeprotein3,HLP3,HPCAL3,HUVISL1,VLP-1,VILIPandVILIP-1)wasoriginallyisolatedbiochemicallyfromchickenretinaasamajorproteinofabout24kDaonSDS-PAGE(1).Followingcloningandsequencingofvisinin,severalvisininlikeproteinswerediscoveredbyhomologyscreening(2,3).Oneofthese,Visinin-likeprotein1isasmallCalciumbindingproteinwhichisveryabundantinthenervoussystemandisfoundonlyinneurons,thoughdifferentneuronshavedifferentlevelsofexpression(4,5).ItisparticularlyconcentratedincerebellarPurkinjecells,andtendstobemostabundantinperikaryaanddendrites.TheproteinbelongstothelargesuperfamlyofcalmodulinandparavalbumintypeproteinswhichfunctionbybindingCalciumions.Calciumbindingalterstheconfomationoftheseproteinsandallowthemtointeractwithotherbindingpartners,thepropertiesofwhichtheymayalter.Visinin-likeprotein1hasfour"EFhand"domains,whicharenegativelychargedhelix-turn-helixpeptideswhichareresponsIBLeforCalciumbinding.Visinin-likeprotein1is191aminoacidsinsizeandhasamolecularweightonSDS-PAGEof22kDa.TheproteinhasrecentlybeensuggestedtobeausefulbioMarkerofAlzheimer"sdiseaseandtraumaticbraininjury(6,7,8). |
Antigen | RecombinantVisinin-likeprotein1expressedandpurifiedfromE.coli. |
AntibodyType | Monoclonal |
Isotype | IgG1 |
OtherNames | Hippocalcin-likeprotein3,HLP3,HPCAL3,HUVISL1,VLP-1,VILIPandVILIP-1 |
Producedin | Mouse |
Applications | WesternBlotting(WB)andImmunocytochemistry(IC).Adilutionof1:1,000-1:2,000isrecommendedforWB.Adilutionof1:500-1:1,000isrecommendedforIC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | Theantibodyreactswitha22kDabandbyWesternblotonbovinecerebellumlysate.Ithasalsobeenusedsuccessfullyforimmunocytochemistry. |
SpeciesAgainst | Human,bovine,ratandmouse.Itisexpectedthatitwillworkonothermammaltissues. |
AntibodyAgainst | Visinin-likeprotein1 |
Form | LyophilisedfromPBS.Contains5%trehalose. |
Appearance | Whitepowder |
Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
ExpiryDate | 12monthsafterpurchase |
GeneralReferences | 1.HatakenakaS,KuoCH,MikiN.Analysisofadistinctiveproteininchickretinaduringdevelopment.BrainRes.312:155-63(1983).2.KunoT,KajimotoY,HashimotoT,MukaiH,ShiraiY,SahekiS,TanakaC.CDNAcloningofaneuralvisinin-likeCa(2+)-bindingprotein.BiochemBiophysResCommun.184:1219-25(1992).3.PolymeropoulosMH,IdeS,SoaresMB,LennonGG.SequencecharacterizationandgeneticmappingofthehumanVSNL1gene,ahomologueoftheratvisinin-likepeptideRNVP1.Genomics.29:273-5(1995).4.BernsteinHG,BaumannB,DanosP,DiekmannS,BogertsB,GundelfingerED,BraunewellKH.Regionalandcellulardistributionofneuralvisinin-likeproteinimmunoreactivities(VILIP-1andVILIP-3)inhumanbrain.JNeurocytol.28:655-62(1999).5.PaterliniM,RevillaV,GrantAL,WisdenWExpressionoftheneuronalcalciumsensorproteinfamilyintheratbrain..Neuroscience.99:205-16(2000)6.LaterzaOF,ModurVR,CrimminsDL,OlanderJV,LandtY,LeeJM,LadensonJH.Identificationofnovelbrainbiomarkers.Clin.Chem.9:1713-21(2006)7.LeeJM,BlennowK,AndreasenN,LaterzaO,ModurV,OlanderJ,GaoF,OhlendorfM,LadensonJH.ThebraininjurybiomarkerVLP-1isincreasedinthecerebrospinalfluidofAlzheimerdiseasepatients.Clin.Chem.10:1617-23(2008).8.TarawnehR,D"AngeloG,MacyE,XiongC,CarterD,CairnsNJ,FaganAM,HeadD,MintunMA,LadensonJH,LeeJM,MorrisJC,HoltzmanDM.Visinin-likeprotein-1:diagnosticandprognosticbiomarkerinAlzheimerdisease.AnnNeurol.70:274-85(2011)doi:10.1002/ana.22448. |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话:PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话:PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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