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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to beta synuclein (C-terminal domain): IgG/R-1683-500/500 ug
商品详细Biosensis/Rabbit antibody to beta synuclein (C-terminal domain): IgG/R-1683-500/500 ug
Biosensis/Rabbit antibody to beta synuclein (C-terminal domain): IgG/R-1683-500/500 ug
Biosensis/Rabbit antibody to beta synuclein (C-terminal domain): IgG/R-1683-500/500 ug
商品编号: R-1683-500
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionBeta-synucleinisasolublecytoplasmicproteinassociatedwithsynapticvesiclesandamemberofthesynucleinfamily.Mutationsinalpha-synucleincauseearlyonsetParkinson"sdisease.Expressionofbetasynucleinmaymodulatealpha-synucleinaggregationfoundinParkinson"sdisease.
BatchNo.Seeproductlabel
Unitsize500ug
AntigenAsyntheticpeptide(AQEAAEEPLIEPLME-C)correspondingtohumanβ-synuclein[99-113]intheC-terminaldomainconjugatedviaadditionalC-terminalCystoDiphtheriatoxoid.
AntibodyTypePolyclonal
ApplicationsWBandIHC.Adilutionof1:500to1:1,000isrecommendedforWesternblot.β-synucleinisasolubleproteinof134aminoacidsanddetectedwith17kDamobilitybywesternblotting.ByIHCtheantibodydetectssynapticsitesinhumanbrainformaldehyde-treatedfrozentissue.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityConfirmedbyWBusingsolublemouseandhumanbrainextracts,reactivityformajorproductdiminishedbypeptideabsorption.Doesnotdetectalpha-synucleinastestedwithrecombinantproteinanddoesnotreactwithLewybodiesinhumanDementiawithLewyBodiesorParkinson"sdiseasebraintissuesections.
SpeciesAgainstHumanandmouseβ-synucleinarehighlyconserved,socross-reactivitywithotherspeciesisexpected.
FormLyophilizedfromPBS,pH7.4.Containsnopreservative.
ReconstitutionReconstitutein500µLofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageLyophilizedat2-4°C.Afterreconstitution,storeat-20°Cinundilutedaliquotsforupto6months.Theantibodymaybestoredshorttermat2-4°Cwithanappropriateantibacterialagent.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
ReferencesCulvenor,J.G.,McLean,C.A.,Cutt,S.,Campbell,B.C.V.,Maher,F.,Jäkälä,P.,Hartmann,T.,Beyreuther,K.,Masters,C.M.,andLi,Q.-X.(1999)Non-AβcomponentofAlzheimer’sdiseaseamyloid(NAC)revisited:NACandα-synucleinarenotassociatedwithAβamyloid.Am.J.Path.155,1173-1181.
Culvenor,J.G.,Rietze,R.L.,Bartlett,P.F.,Masters,C.L.,andLi,Q.-X.(2002)Oligodendrocytesfromneuralstemcellsexpressα-synuclein:IncreasednumbersfromPresenilin1deficientmice.NeuroReport13,1305-1308.
Li,Q.X.,Campbell,B.C.V.,McLean,C.A.,Thyagarajan,D.,Gai,W.P.,Kapsa,R.M.,Beyreuther,K.,Masters,C.L.,andCulvenor,J.G.(2002)Plateletα-andγ-synucleinsinParkinson"sdiseaseandnormalcontrolsubjects.JournalofAlzheimer’sDisease4,309-315.
Quilty,M.C.,Gai,W.-P.,Pountney,D.L.,West,A.K.,andVickers,J.C.(2003)Localizationofalpha,beta,andgammasynucleinduringneuronaldevelopmentandalterationsassociatedwiththeneuronalresponsetoaxonaltrauma.ExpNeurol182,195-207.
George,S.Mok,S.S.,Nurjono,M.,Ayton,S.,Finkelstein,D.I.,Masters,C.L.,Li,Q.-X.andCulvenor,J.G.(2010)α-SynucleintransgenicmicerevealcompensatoryincreasesinParkinson"sDisease-associatedproteinsDJ-1andParkinandhaveenhancedα-synucleinandPINK1levelsafterrotenonetreatment.J.Mol.Neurosci.42,243-254.
Ia,K.K.,Jeschke,G.R.,Deng,Y.,Kamaruddin,M.A.,Williamson,N.A.,Scanlon,D.B.,CULVENOR,J.G.,Hossain,M.I.,Purcell,A.W.,Liu,S.,Zhu,H.J.,Catimel,B.,Turk,B.E.andCheng,H.C.(2011)DefiningthesubstratespecificitydeterminantsrecognizedbytheactivesiteofC-TerminalSrcKinase-HomologousKinase(CHK)andidentificationofbetaSynucleinasapotentialCHKphysiologicalsubstrate.Biochemistry,50,6667-6677
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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