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Biosensis/Rabbit antibody to beta synuclein (C-terminal domain): IgG/R-1683-500/500 ug
Biosensis/Rabbit antibody to beta synuclein (C-terminal domain): IgG/R-1683-500/500 ug
商品编号:
R-1683-500
品牌:
Biosensis inc
市场价:
¥5940.00
美元价:
3564.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | Beta-synucleinisasolublecytoplasmicproteinassociatedwithsynapticvesiclesandamemberofthesynucleinfamily.Mutationsinalpha-synucleincauseearlyonsetParkinson"sdisease.Expressionofbetasynucleinmaymodulatealpha-synucleinaggregationfoundinParkinson"sdisease. |
BatchNo. | Seeproductlabel |
Unitsize | 500ug |
Antigen | Asyntheticpeptide(AQEAAEEPLIEPLME-C)correspondingtohumanβ-synuclein[99-113]intheC-terminaldomainconjugatedviaadditionalC-terminalCystoDiphtheriatoxoid. |
AntibodyType | Polyclonal |
Applications | WBandIHC.Adilutionof1:500to1:1,000isrecommendedforWesternblot.β-synucleinisasolubleproteinof134aminoacidsanddetectedwith17kDamobilitybywesternblotting.ByIHCtheantibodydetectssynapticsitesinhumanbrainformaldehyde-treatedfrozentissue.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | ConfirmedbyWBusingsolublemouseandhumanbrainextracts,reactivityformajorproductdiminishedbypeptideabsorption.Doesnotdetectalpha-synucleinastestedwithrecombinantproteinanddoesnotreactwithLewybodiesinhumanDementiawithLewyBodiesorParkinson"sdiseasebraintissuesections. |
SpeciesAgainst | Humanandmouseβ-synucleinarehighlyconserved,socross-reactivitywithotherspeciesisexpected. |
Form | LyophilizedfromPBS,pH7.4.Containsnopreservative. |
Reconstitution | Reconstitutein500µLofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Lyophilizedat2-4°C.Afterreconstitution,storeat-20°Cinundilutedaliquotsforupto6months.Theantibodymaybestoredshorttermat2-4°Cwithanappropriateantibacterialagent.Avoidfreeze-thawcycles. |
ExpiryDate | 12monthsafterpurchase |
References | Culvenor,J.G.,McLean,C.A.,Cutt,S.,Campbell,B.C.V.,Maher,F.,Jäkälä,P.,Hartmann,T.,Beyreuther,K.,Masters,C.M.,andLi,Q.-X.(1999)Non-AβcomponentofAlzheimersdiseaseamyloid(NAC)revisited:NACandα-synucleinarenotassociatedwithAβamyloid.Am.J.Path.155,1173-1181. Culvenor,J.G.,Rietze,R.L.,Bartlett,P.F.,Masters,C.L.,andLi,Q.-X.(2002)Oligodendrocytesfromneuralstemcellsexpressα-synuclein:IncreasednumbersfromPresenilin1deficientmice.NeuroReport13,1305-1308. Li,Q.X.,Campbell,B.C.V.,McLean,C.A.,Thyagarajan,D.,Gai,W.P.,Kapsa,R.M.,Beyreuther,K.,Masters,C.L.,andCulvenor,J.G.(2002)Plateletα-andγ-synucleinsinParkinson"sdiseaseandnormalcontrolsubjects.JournalofAlzheimersDisease4,309-315. Quilty,M.C.,Gai,W.-P.,Pountney,D.L.,West,A.K.,andVickers,J.C.(2003)Localizationofalpha,beta,andgammasynucleinduringneuronaldevelopmentandalterationsassociatedwiththeneuronalresponsetoaxonaltrauma.ExpNeurol182,195-207. George,S.Mok,S.S.,Nurjono,M.,Ayton,S.,Finkelstein,D.I.,Masters,C.L.,Li,Q.-X.andCulvenor,J.G.(2010)α-SynucleintransgenicmicerevealcompensatoryincreasesinParkinson"sDisease-associatedproteinsDJ-1andParkinandhaveenhancedα-synucleinandPINK1levelsafterrotenonetreatment.J.Mol.Neurosci.42,243-254. Ia,K.K.,Jeschke,G.R.,Deng,Y.,Kamaruddin,M.A.,Williamson,N.A.,Scanlon,D.B.,CULVENOR,J.G.,Hossain,M.I.,Purcell,A.W.,Liu,S.,Zhu,H.J.,Catimel,B.,Turk,B.E.andCheng,H.C.(2011)DefiningthesubstratespecificitydeterminantsrecognizedbytheactivesiteofC-TerminalSrcKinase-HomologousKinase(CHK)andidentificationofbetaSynucleinasapotentialCHKphysiologicalsubstrate.Biochemistry,50,6667-6677 |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话:PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话:PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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