生物传感器/兔抗人APP抗体：全血清/R-070-100/100µl
商品编号：
R-070-100
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | FUNCTION:Functionsasacellsurfacereceptorandperformsphysiologicalfunctionsonthesurfaceofneuronsrelevanttoneuritegrowth,neuronaladhesionandaxonogenesis.Involvedincellmobilityandtranscriptionregulationthroughprotein-proteininteractions.CanpromotetranscriptionactivationthroughbindingtoAPBB1/Tip60andinhibitNotchsignalingthroughinteractionwithNumb.Couplestoapoptosis-inducingpathwayssuchasthosemediatedbyG(O)andJIP.InhibitsG(o)alphaATPaseactivity.ActsasakinesinImembranereceptor,mediatingtheaxonaltransportofbeta-secretaseandpresenilin1.Maybeinvolvedincopperhomeostasis/oxidativestressthroughcopperionreduction.CanregulateneuriteoutgrowththroughbindingtocomponentsoftheextracellularmatrixsuchasheparinandcollagenIandIV.FUNCTION:Beta-amyloidpeptidesarelipophilicmetalchelatorswithmetal-reducingactivity.Bindtransientmetalssuchascopper,zincandiron.Ratandmousebeta-amyloidpeptidesbindonlyweaklytransientmetalsandhavelittlereducingactivityduetosubstitutionsoftransientmetalchelatingresidues.Beta-APP42mayactivatemononuclearphagocytesinthebrainandelicitinflammatoryresponses.PromotesbothtauaggregationandTPKII-mediatedphosphorylation(Bysimilarity).FUNCTION:Thegamma-CTFpeptidesaswellasthecaspase-cleavedpeptides,includingC31,arepotentenhancersofneuronalapoptosis.SUBUNIT:Binds,viaitsC-terminus,tothePIDdomainofseveralcytoplasmicproteins,includingAPBBfamilymembers,theAPBAfamily,MAPK8IP1,SHC1,NumbandDab1.BindingtoDab1inhibitsitsserinephosphorylation.AlsointeractswithGPCR-likeproteinBPP,FPRL1,APPBP1,IB1,KNS2(viaitsTPRdomains),APPBP2(viaBaSS)andDDB1.Invitro,itbindsMAPTviatheMT-bindingdomains.AssociateswithmicrotubulesinthepresenceofATPandinakinesin-dependentmanner.Interacts,throughaC-terminaldomain,withGNAO1.Amyloidbeta-42bindsCHRNA7inhippocampalneurons.Beta-amyloidassociateswithHADH2.TISSUESPECIFICITY:differentisoformsindifferenttissues:kidney.brain.liver.hippocampus,substanianigraparscompactaandcerebellum.Inthecerebellum,alltheisoformsareabundantlyexpressedinPurkinjecells. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Syntheticpeptides(C-ETHLHWHTVAKET,aa:145-157;C-HAHFQKAKERLEAKHRER,aa:388-405;C-KKKQYTSIHHGVVE,aa:724-737)aspartsofhumanAPPisoformAconjugatedtoKLH |
| OtherNames | AmyloidbetaA4protein;ABPP;Alzheimerdiseaseamyloidprotein;Cerebralvascularamyloidpeptide;CVAP;Proteasenexin-II;PN-II;APPI;PreA4;A4;AD1 |
| Accession | APP_HUMAN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC.Recommendedtobeusedatadilutionof1:500to1:3000forimmunohistochemistry.Thisantiserumhasnotyetbeentestedforwesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SpecificityforAPPwasconfirmedbyIHC. |
| Cross-reactivity | ThisantiserumisknowntoreactwithratAPP.Reactivitywithotherspecieshavenotyetbeentested. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| References | 1.Wilson,C.A.,etal.,J.Neurosci.Res.74:361-369(2003). 2.Andreasen,N.,etal.,WorldJ.Biol.Psychiatry4:147-155(2003). 3.Guenette,S.Y.NeuromolecularMed.4:147-160(2003). |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
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B-100-PS型
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2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
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PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
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PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
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感觉神经系统
PE-1253-100型
TR-100-FJ
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神经内分泌
M-1728-100型
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PE-1243-25
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PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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