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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/兔抗人LRRK2(946-962)抗体:亲和纯化/R-183-50/50µg
商品详细Biosensis/兔抗人LRRK2(946-962)抗体:亲和纯化/R-183-50/50µg
Biosensis/兔抗人LRRK2(946-962)抗体:亲和纯化/R-183-50/50µg
Biosensis/兔抗人LRRK2(946-962)抗体:亲和纯化/R-183-50/50µg
商品编号: R-183-50
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
LRRK2isamemberoftheleucine-richrepeatkinasefamily.Itsroleisyetunknownbutitmayplayaroleinthephoshorylationofproteinscentraltoparkinsondiseases.LRRK2containsanankryinrepeatregion,aleucine-richrepeat(LRR)domain,akinasedomain,aDFG-likemotif,aRASdomain,aGTPasedomain,aMLK-likedomainandaWD40domain.LRRK2ispresentinthecytoplasmbutalsoassociateswiththemitochondrialoutermembrane.DefectsinLRRK2arethecauseofParkinsondisease8(PARK8).Parkinsondiseaseischaracterisedbybradykinesia,restingtremor,muscularrigidityandposturalinstABIlity,aswellasbyaclinicallysignificantresponsetotreatmentwithlevodopa.ThepathologyinvolvesthelossofdopaminergicneuronsinthesubstantianigraandthepresenceofLewybodies(intraneuronalaccumulationsofaggregatedproteins),insurvivingneuronsinvariousareasofthebrain.PARK8isanautosomal-dominantlate-onsetparkinsonism,characterizedbyonsetfrom50to65years,withslowprogressionandrelativelybenigncourse.
RelatedproductsLeucine-RichRepeatKinase2inhibitorLRRK2-IN-1
BatchNo.Seeproductlabel
Unitsize50µg
AntigenAsyntheticpeptide(CLKRKRKILSSDDSLRSS)correspondingtoaminoacids946-962ofthehumanLRRK2proteinconjugatedtodiptheriatoxinwasusedastheimmunogen.
OtherNamesLeucine-richrepeatserine/threonine-proteinkinase2;Dardarin;LRRK2;PARK8
AccessionQ5S007_HUMAN
ProducedinRabbit
PurityAffinitypurified
ApplicationsIHC.Adilutionrangeof1:500to1:1000isrecommended.Otherapplicationshavenotyetbeentested.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificitySpecificitywasdemonstratedbyimmunohistochemistry.TheantibodystainspositivetanglesininferiortemporalcortexofhumanbrainaffectedbyAlzheimer"sdisease.
Cross-reactivityThisantiserumhasbeensuccessfullytestedinhuman.Otherspecieshavenotyetbeentested.
BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.
FormLyophilised
ReconstitutionReconstitutewith50µlsterilewaterandcentrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
References1.ZimprichA,etal.Neuron44:601-607(2004).
2.OtaT,etal.Nat.Genet.36:40-45(2004).
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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