4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to Microtubule-associated protein tau (240-450)/MAPT/TAU: IgG/R-177-250/250 µg
商品详细Biosensis/Rabbit antibody to Microtubule-associated protein tau (240-450)/MAPT/TAU: IgG/R-177-250/250 µg
Biosensis/Rabbit antibody to Microtubule-associated protein tau (240-450)/MAPT/TAU: IgG/R-177-250/250 µg
Biosensis/Rabbit antibody to Microtubule-associated protein tau (240-450)/MAPT/TAU: IgG/R-177-250/250 µg
商品编号: R-177-250
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
FUNCTION:PromotesmicrotubuleassemblyandstABIlity,andmightbeinvolvedintheestablishmentandmaintenanceofneuronalpolarity.TheC-terminusbindsaxonalmicrotubuleswhiletheN-terminusbindsneuralplasmamembranecomponents,suggestingthattaufunctionsasalinkerproteinbetweenboth.Axonalpolarityispredeterminedbytaulocalization(intheneuronalcell)inthedomainofthecellbodydefinedbythecentrosome.TheshortisoformsallowplasticityoftheCytoskeletonwhereasthelongerisoformsmaypreferentiallyplayaroleinitsstabilization. SUBCELLULARLOCATION:Cytoplasm;cytosol.Cellmembrane.Mostlyfoundintheaxonsofneurons,inthecytosolandinassociationwithplasmamembranecomponents.ALTERNATIVEPRODUCTS:8namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.Isoformsdifferfromeachotherbythepresenceorabsenceofupto5ofthe15exons.Oneoftheseoptionalexonscontainstheadditionaltau/MAPrepeat.TISSUESPECIFICITY:Expressedinneurons.IsoformPNS-tauisexpressedintheperipheralnervoussystemwhiletheothersareexpressedinthecentralnervoussystem.DEVELOPMENTALSTAGE:Four-repeat(typeII)tauisexpressedinanadult-specificmannerandisnotfoundinfetalbrain,whereasthree-repeat(typeI)tauisfoundinbothadultandfetalbrain.DOMAIN:Thetau/MAPrepeatbindstotubulin.InAlzheimerdisease,theneuronalcytoskeletoninthebrainisprogressivelydisruptedandreplacedbytanglesofpairedhelicalfilaments andstraightfilaments,mainlycomposedofhyperphosphorylatedformsofMicrotubule-associatedproteinTau.DefectsinMicrotubule-associatedproteinTauareacauseoffrontotemporaldementiaandparkinsonismlinkedtochromosome17,aswellasanumberofotherneurodegenerativediseases.
BatchNo.Seeproductlabel
Unitsize250µg
AntigenRecombinanthumanMicrotubule-associatedproteintau(aa240-450)hasbeenusedastheimmunogen.
OtherNamesNeurofibrillarytangleprotein;Pairedhelicalfilament-tau;PHF-tau;MAPT;MTBT1;TAU
AccessionTAU_HUMAN
ProducedinRabbit
PurityProteinGpurifiedIgG
ApplicationsIH/IH(P):Thisantibodyworkssuperblyinbothinparaffin-embeddedandfrozensections.Aworkingdilutionof1:100to1:1000isrecommended.ThisantiserumrecognisesbothphosphorylatedandunphosphorylatedformsofTauprotein.Westernblot:1:500-1:2000.WilldetectmultipleisoformsofTau;Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThespecificityforTauproteinwasconfirmedbyIHCandWBandELISA.
Cross-reactivityThisantiserumcrossreactswithTauproteinofhuman,ratandmouseorigins.
BlastitIfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit.
FormLyophilised
ReconstitutionReconstitutein250µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
References1.GoedertM,etal.(1988)Proc.Natl.Acad.Sci.U.S.A.85:4051-4055.
2.GoedertM,etal.(1989)Neuron3:519-526.
3.LeeG,etal.(1989)Neuron2:1615-1624.
4.AndreADIsA,etal.(1992)Biochemistry31:10626-10633.
5.JakesR,etal.(1991)EMBOJ.10:2725-2729.
6.CrippsD,etal.(2006)J.Biol.Chem.281:10825-10838.
7.MaasT,etal.(2000)J.Biol.Chem.275:15733-15740.
8.NacharajuP,etal.(1997)J.NeuRochem.69:1709-1719.
9.WintjensR,etal.(2001)J.Biol.Chem.276:25150-25156.
10.OlivaR,etal.(2004)Ann.Neurol.55:448-449.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616