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Biosensis/Rabbit antibody to Parkin (305-323): whole serum/R-113-100/100 µl
Biosensis/Rabbit antibody to Parkin (305-323): whole serum/R-113-100/100 µl
商品编号：
R-113-100
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | FUNCTION:FunctionswithinamultiproteinE3ubiquitinligasecomplex,catalyzingthecovalentattachmentofubiquitinmoietiesontosubstrateproteins.ThesesubstratesincludeSYT11,CCNE1,GPR37,STUB1,a22kDaO-linkedglycosylatedisoformofSNCAIPandSEPT5.Mayplayamoregeneralroleintheubiquitinproteasomalpathwaybyparticipatingintheremovaland/ordetoxificationofabnormallyfoldedordamagedprotein.LossofthisubiquitinligaseactivityappearstobethemechanismunderlyingpathogenesisofPARK2.Mayprotectneuronsagainstalphasynucleintoxicity,proteasomaldysfunction,GPR37accumulation,andkainate-inducedexcitotoxicity.Mayplayaroleincontrollingneurotransmittertraffickingatthepresynapticterminalandincalcium-dependentexocytosis.RegulatescyclinEduringneuronalapoptosis.Mayrepresentatumorsuppressorgene.SUBCELLULARLOCATION:Cytoplasm.Co-localizeswithSTY11inneutrites.Co-localizeswithSNCAIPinbrainstemLewybodies.TISSUESPECIFICITY:Highlyexpressedinthebrainincludingthesubstantianigra.Expressedinheart,testisandskeletalmuscle.Expressionisdown-regulatedorabsentintumorbiopsies,andabsentinthebrainofPARK2patients.Overexpressionprotectsdopamineneuronsfromkainate-mediatedapoptosis. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(RILGEEQYNRYQQYGAEEC)aspartofhumanParkinconjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen. |
| OtherNames | UbiquitinE3ligasePRKN;Parkinsonjuvenilediseaseprotein2;Parkinsondiseaseprotein2;PARK2;PRKN |
| Accession | PRKN2_HUMAN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC,WB,immunoblot,1-siteELISA.Adilutionof1:500to1:2000isrecommendedfortheseapplications.Thisantiserumstainstrigeminalmotorneuronsinratbrainstem.A50kDabandwasidentifiedinratbrainextractusingwesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThisantiserumiisknowntospecificallyrecogniseParkinshownbyIHCandWB. |
| Cross-reactivity | ThisantibodyisknowntoreactwithParkinofguineapigandrat. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | 1.E.RubiodelaTorreetal(2009)Combinedkinaseinhibitionmodulatesparkininactivation.HumMolGenet.2009Mar1;18(5):809-23. 2.D"AgataV.etal(2009)Parkinexpressionprofileindopamined3receptorknock-outmicebrains.NeuRochemRes.2009Feb;34(2):327-32. 3.TamoW.etal(2007)Parkinisexpressedinvascularendothelialcells.NeurosciLett.2007Jun4;419(3):199-201. 4.TrimmerP.A.etal(2004)Parkinson"sdiseasetransgenicmitochondrialcybridsgenerateLewyinclusionbodies.JNeurochem.2004Feb;88(4):800-12. 5.DenisonS.R.etal(2004)AlterationsinthecommonfragilesitegeneParkininovarianandothercancers.Oncogene.2003Nov13;22(51):8370-8. 6.PawlykA.C.etal(2003)Novelmonoclonalantibodiesdemonstratebiochemicalvariationofbrainparkinwithage.JBiolChem.2003Nov28;278(48):48120-8. 7.HorowitzJ.M.etal(2001)Spatialdistribution,cellularintegrationandstagedevelopmentofParkinproteininXenopusbrainBrainResDevBrainRes.2001Jan31;126(1):31-41. |
| References | 1.Hottorietal.(1998)BiochemBiophysResCommun.249(3):754-758 2.Kitadaetal.(1998).Nature.392:605-608 |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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