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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to SUMO-1 (6-21): whole serum/R-115-100/100 µl
商品详细Biosensis/Rabbit antibody to SUMO-1 (6-21): whole serum/R-115-100/100 µl
Biosensis/Rabbit antibody to SUMO-1 (6-21): whole serum/R-115-100/100 µl
Biosensis/Rabbit antibody to SUMO-1 (6-21): whole serum/R-115-100/100 µl
商品编号: R-115-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:Ubiquitin-likeproteinwhichbindstoawiderangeoftargetproteins.DoesnotseemtobeinvolvedinproteindegradationandmayfunctionasanantagoNISTofubiquitininthedegradationprocess.Playsaroleinanumberofcellularprocessessuchasnucleartransport,DNAreplicationandrepair,mitosisandsignaltransduction.InvolvedintargetingRANGAP1tothenuclearporecomplexproteinRANBP2.SUBUNIT:CovalentlyattachedtoanumberofproteinssuchasPML,RANGAP1,HIPK2,SP100,p53,p73alpha,MDM2,JUNandDNMT3B.AlsointeractswithHIF1A,HIPK2,HIPK3,CHD3,PIAS1,EXOSC9,TDG,RAD51andRAD52.SUBCELLULARLOCATION:Nucleus;nuclearmembrane.Nucleus;nucleoplasm;nuclearspeckle.Cytoplasm.SIMILARITY:Belongstotheubiquitinfamily.SMT3subfamily.SIMILARITY:Contains1ubiquitin-likedomain.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(AKPSTEDLGDKKEGEY)aspartofhumanSUMO-1peptide(aa:6-21)conjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen.ThisantigenishomologouswithSUMO-1ofrat.
OtherNamesSmallubiquitin-relatedmodifier1;Ubiquitin-likeproteinSMT3C;SMT3homolog3;Ubiquitin-homologydomainproteinPIC1;Ubiquitin-likeproteinUBL1;GAP-modifyingprotein1;GMP1;Sentrin;SUMO1;SMT3C;SMT3H3;UBL1
AccessionSUMO1_HUMAN
ProducedinRabbit
PurityWholeserum
ApplicationsIHC,WB.Adilutionof1:1000to1:2000isrecommendedforimmunohistochemistryand1:2000to1:4000forwesternblot.CelllysatefromHelaandNIH-3T3celllysatesmaybeusedasapositivecontrol,andforIHC,lungcarcinomamaybeused.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThisantiserumrecogniseshumanSUMO-1andnotubiquitin.
Cross-reactivityThisantiserumisknowntocrossreactwithratandhumanSUMO-1.
BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
References1.Yang,S.H.etal.Mol.Cell13(4):611-617(2004).
2.Ohshima,T.etal.J.Biol.Chem.278(51):50833-50842(2003).
3.Bailey,D.etal.J.Biol.Chem.279(1):692-703(2004).
4.Ling,Y.etal.NucleicAcidsRes.32(2):598-610(2004).
5.Pountney,D.L.etal.Exp.Neurol.184(1):436-446(2003).
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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