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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to Synphilin-1 (911-919): whole serum/R-117-100/100 µl
商品详细Biosensis/Rabbit antibody to Synphilin-1 (911-919): whole serum/R-117-100/100 µl
Biosensis/Rabbit antibody to Synphilin-1 (911-919): whole serum/R-117-100/100 µl
Biosensis/Rabbit antibody to Synphilin-1 (911-919): whole serum/R-117-100/100 µl
商品编号: R-117-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionSynucleinalphainteractingprotein(Synphilin-1)containsseveralprotein-proteininteractiondomainsandinteractswithalphasynucleininneurons.MutationsofSNCAIPhavebeenlinkedtoParkinsondisease.Theaminoacidsequenceofsynphilin-1sharesahighlevelofidentitywithitshumancounterpart,particularlyinregionscontainingankyrin-likemotifsandthecoiled-coildomain.Expressionpatternofsynphilin-1intissuesissimilarinbothmouseandhuman.Synphilin-1hasanimportantroleintheformationofaggregatesandcytotoxicityinParkinsondiseaseandalsoDorfinmaybeinvolvedinthepathogenicprocessbyubiquitylationofsynphilin-1.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(CASKGKNKAA)aspartofhumansynphilin-1aconjugatedtoKLHhasbeenusedastheimmunogen.
OtherNamesSynphilin-1aprotein;synucleinalphainteractingprotein;Synphilin-1;Synphilin1;SNCAIP
AccessionSynphilin-1aprotein_HUMAN
ProducedinRabbit
PurityWholeserum
ApplicationsIHC,WB.Adilutionof1:1000to1:2000isrecommendedforimmunohistochemistryand1:500-1:1000forwesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityAhighlevelofspecificityhasbeenshownforthisantiserumbyIHConhumanbrain.
Cross-reactivityThisantiserumisknowntoreactwithratandhumansynphilin-1a.
BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
References1.Kruger,R.CellTissueRes.318(1),195-199(2004)
2.Lee,G.,etal.J.Biol.Chem.279(8),6834-6839(2004)
3.Tanaka,M.,etal.J.Biol.Chem.279(6),4625-4631(2004)
4.Nagano,Y.,etal.J.Biol.Chem.278(51),51504-51514(2003)
5.Marx,F.P.,etal.Hum.Mol.Genet.12(11),1223-1231(2003)
6.Junn,E.,etal.J.Biol.Chem.277(49),47870-47877(2002)
7.Chung,K.K.,etal.Nat.Med.7(10),1144-1150(2001)
8.Kawamata,H.,etal.J.NeuRochem.77(3),929-934(2001)
9.Engelender,S.,etal.Nat.Genet.22(1),110-114(1999)
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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