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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/兔早老素1环区多克隆抗体:IgG/R-1680-500/500μg
商品详细Biosensis/兔早老素1环区多克隆抗体:IgG/R-1680-500/500μg
Biosensis/兔早老素1环区多克隆抗体:IgG/R-1680-500/500μg
Biosensis/兔早老素1环区多克隆抗体:IgG/R-1680-500/500μg
商品编号: R-1680-500
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionPresenilin-1(PSEN1)isamulti-passmembraneproteinandcomponentofthegamma-secretasecomplex.PSEN1isthoughttoplayaroleinintracellularsignalingandgeneexpressionorinlinkingchromatintothenuclearmembrane.Itmayalsoplayaroleinhematopoiesis.DefectsinPSEN1areacauseofAlzheimerdiseasetype3(AD3),afamilialearly-onsetformofAlzheimerdisease(Ref:SWISS-Prot).
BatchNo.Seeproductlabel
Unitsize500ug
AntigenAsyntheticpeptide(GDPEAQRRVSKNSKYNA-C)correspondingtohumanPS1[301-317]intheloopregionconjugatedviaadditionalC-terminalCystoDiphtheriatoxoid.
AntibodyTypePolyclonal
OtherNamesPresenilin1;PS-1;ProteinS182;PS1-CTF12;PSEN1;AD3;PS1;PSNL1
ProducedinRabbit
ApplicationsWesternBlot.Suggesteddilutionof1:1,000isrecommendedforWB.Fulllengthpresenilin1(467aa)hasrelativeMWofabout45kDa,withthisantibodymostcommonlydetectedascleavedCTFof19kDa.Humanormousebrainsamplescommonlypreparedwithreducingagent(50mMDTT),urea(2.3M),SDS(1.5%)in62.5mMTris-HCLpH6.8samplebuffer(withoutboiling)heatingto50Cfor15min.Biosensisrecommendsthattheoptimalworkingdilutionshouldbedeterminedbytheenduser.
SpecificityConfirmedbyWesternblottingusingtransfectedcells,presenilin1knock-outmousecellsandmouseandhumanbrain.
SpeciesAgainstHuman;mouse;rat;guineapig.Presenilinproteinsarehighlyconserved,socross-reactivitywithotherspeciesisexpected.
FormLyophilizedfromPBS,pH7.4.Containsnopreservative.
ReconstitutionReconstitutein500µLofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageShorttermstorageat2-8°Cforoneweek.At-20°Casanundilutedliquidforupto12months.
ExpiryDate12monthsafterpurchase
ReferencesCulvenor,J.G.,Ilaya,N.T.,Ryan,M.T.,Canterford,L.,Hoke,D.,Williamson,N.A.,McLean,C.A.,Masters,C.L.,and1.Evin,G.(2004)CharacterizationofPresenilincomplexfrommouseandhumanbrainusingBlueNativegelelectrophoresisrevealshighexpressioninembryonicbrainandminimalchangeincomplexmobilitywithPresenilinmutations.Eur.J.Biochem.271,375-385.
Ilaya,N.T.,Evin,G.,Masters,C.L.,andCulvenor,J.G.(2004)Nicastrinexpressioninmouseperipheraltissuesisnotco-ordinatedwithPresenilinandishighinmuscle.J.NeuRochem.91,230-237.3.Beher,D.,Fricker,M.,NADIn,A.,Clarke,E.E.,Wrigley,J.D.J.,Li,Y.-M.,Culvenor,J.G.,Masters,C.L.,Harrison,T.,andShearman,M.S.(2003)InvitroCharacterizationofthePresenilin-dependentγ-secretasecomplexusinganovelaffinityligand.Biochem.42,8133-8142.
Evin,G.,Smith,M.J.,Tziotis,A.,McLean,C.,Canterford,L.,Sharples,R.A.,Cappai,R.,Weidemann,A.,Beyreuther,K.,Cotton,R.G.H.,Masters,C.L.,andCulvenor,J.G.(2002)AlternativetranscriptsofPresenilin-1associatedwithFrontotemporalDementia.NeuroReport13,917-921.
Evin,G.,Sharples,R.A.,Weidemann,A.,Reinhard,F.B.M.,Carbone,V.,Culvenor,J.G.,Holsinger,R.M.D.,Sernee,M.F.,Beyreuther,K.,andMasters,C.L.(2001)AspartylproteaseinhibitorpepstatinbindstothepresenilinsofAlzheimer"sdisease.Biochem.40,8359-8368.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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