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Biosensis/Sheep antibody to alpha synuclein (116-131): affinity purified/S-075-50/50 µg
Biosensis/Sheep antibody to alpha synuclein (116-131): affinity purified/S-075-50/50 µg
商品编号：
S-075-50
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | Alphasynucleinisanabundant140aminoacidneuronalprotein,expressedprimarilyatpresynapticterminalsinthecentralnervoussystem.Alphasynucleinhasbeenassociatedwithseveralneurodegenerativediseases.Apointmutationinthegenecodingforthealpha-synucleinproteinwasthefirstdiscoverylinkingthisproteintoararefamilialformofParkinson"sdisease(PD).Subsequently,othermutationsinthealpha-synucleingenehavebeenidentifiedinfamilialPD.TheaggregatedproteinaceousinclusionscalledLewybodiesfoundinPDandcorticalLewybodydementia(LBD)werediscoveredtobepredominantlyalpha-synuclein.Aberrantaggregationofalpha-synucleinhasbeendetectedinanincreasingnumberofneurodegenerativediseases,collectivelyknownassynucleopathies.Alpha-synucleinexistsphysiologicallyinbothsolubleandmembrane-boundstates,inunstructuredandalpha-helicalconformations,respectively.Thephysiologicalfunctionofalpha-synucleinappearstorequireitstranslocationbetweenthesesubcellularcompartmentsandinterconversionbetweenthe2conformations.Abnormalprocessingofalpha-synucleinispredictedtoleadtopathologicalchangesinitsbindingpropertiesandfunction. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µg |
| Antigen | Asyntheticpeptide(CMPVDPDNEAYEMPSEE)ofhumanalphasynucleinprotein(aa:116-131)conjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen. |
| OtherNames | Non-AbetacomponentofADamyloid;Non-A4componentofamyloidprecursor;NACP |
| Accession | SYUA_HUMAN |
| Producedin | Sheep |
| Purity | Affinitypurifiedanddialysedagainstphosphatebufferedsaline(PBS).Contains0.02%sodiumazide. |
| Applications | IHC,WB,ELISA.Recommendedtobeusedataconcentrationof1µg/mlforimmunohistochemistry(Paraffinsections);0.5µg/mlforWBandimmunoblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Thisantiserumspecificallydetectsalphasynuclein. |
| Cross-reactivity | Thisantibodyisknowntoreactwithalphasynucleinofhuman,mouse,ratandotherrodents. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein50µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | 1.KuoY.M.etal.(2010)ExtensiveentericnervoussystemabnormalitiesinmicetransgenicforartificialchromosomescontainingParkinsondisease-associatedalpha-synucleingenemutationsprecedecentralnervoussystemchanges.HumMolGenet.May1;19(9):1633-50 2.PelkonenA.etal.(2010)Stimulateddopamineoverflowandalpha-synucleinexpressioninthenucleusaccumbenscoredistinguishratsbredfordifferentialethanolpreference.JNeuRochem.2010Aug;114(4):1168-76. 3.Alvesetal.(2008)StriatalandnigralpathologyinalentiviralratmodelofMachado-JosephdiseaseHumMolGenet.2008Jul15;17(14):2071-83. |
| References | 1.Lundvigetal,BrainResMolBrainRes134,3-17(Mar24,2005). 2.Bennett,PharmacolTher105,311-31(Mar,2005). 3.Vekrellis,etal.,MolNeurobiol30,1-21(Aug,2004). 4.Martin,etal.,ProteinPeptLett11,229-37(Jun,2004). 5.Doherty,etal.,ActaNeuropathol(Berl)107,169-75(Feb,2004). 6.Goedert,CurrOpinGenetDev11,343-51(Jun,2001). 7.Saito,etal.,JNeurolSci177,48-59(Aug1,2000). 8.LückingC.B.etal.,CellMolLifeSci.2000Dec;57(13-14):1894-908. 9.Kahle,etal.,AnnNYAcadSci920,33-41(2000). 10.Clayton,etal.,TrendsNeurosci21,249-54(Jun,1998). |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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