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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to human Myeloperoxidase (MPO): IgG/R-133-250/250 µg
商品详细Biosensis/Rabbit antibody to human Myeloperoxidase (MPO): IgG/R-133-250/250 µg
Biosensis/Rabbit antibody to human Myeloperoxidase (MPO): IgG/R-133-250/250 µg
Biosensis/Rabbit antibody to human Myeloperoxidase (MPO): IgG/R-133-250/250 µg
商品编号: R-133-250
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:Partofthehostdefensesystemofpolymorphonuclearleukocytes.ItisresponsIBLeformicrobicidalactivityagainstawiderangeoforganisms.InthestimulatedPMN,MPOcatalyzestheproductionofhypohalousacids,primarilyhypochlorousacidinphysiologicsituations,andothertoxicintermediatesthatgreatlyenhancePMNmicrobicidalactivity.MPOisanimportantMarkerformyeloidcells,fromthepromyelocytestageandtothematureforms.CATALYTICACTIVITY:Donor+H2O2=oxidizeddonor+2H2O.CATALYTICACTIVITY:Cl-+H2O2=HOCl+2H2O.COFACTOR:Binds1calciumionperheterodimer.COFACTOR:Binds1hemeB(iron-protoporphyrinIX)groupcovalentlyperheterodimer.SUBUNIT:Tetrameroftwolightchainsandtwoheavychains.SUBCELLULARLOCATION:Lysosome.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.DISEASE:DefectsinMPOarethecauseofmyeloperoxidasedeficiency(MPD).MPDisanautosomalrecessivedefectthatresultsindisseminatedcandidiasis.SIMILARITY:Belongstotheperoxidasefamily.XPOsubfamily.MicrogliaandastrocytesareknowntoexpressMPOaswell.
BatchNo.Seeproductlabel
Unitsize250µg
AntigenMyeloperoxidaseisolatedfromhumanpolymorphonuclearleucocytes
OtherNamesMPO
AccessionMPO_HUMAN
ProducedinRabbit
PurityIgG
ApplicationsIHC,WB.Adilutionof1:500-1:1000isrecommended.Thisantiserumworkssuperblyforstainingofparaffin-embeddedtissuesectionsfixedinformalin,frozensectionsandcellcytospins.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThisantiserumreactswithhumanmyeloperoxidase.
Cross-reactivityHuman
BlastitIfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit.
FormLyophilised
ReconstitutionReconstitutein250µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability.
References1.ArberD.A.etal.AmJClinPathol.2001;116:25-33
2.KimuraSetal.Proteins1988;3:113-20.
3.WeilS.C.etal.Science1988;240:790-2.
4.LanzaF.JMolMed1998;76:676-81.
5.PinkusG.S.ModPathol1991;4:733-41.
6.GrayE.etal.BrainPathol.2008Jan;18(1):86-95.
7.MakiR.A.etal.JBiolChem.2009Jan30;284(5):3158-69.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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