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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to mouse superoxide dismutase (SOD1; 24-36): whole serum/R-126-100/100 µl
商品详细Biosensis/Rabbit antibody to mouse superoxide dismutase (SOD1; 24-36): whole serum/R-126-100/100 µl
Biosensis/Rabbit antibody to mouse superoxide dismutase (SOD1; 24-36): whole serum/R-126-100/100 µl
Biosensis/Rabbit antibody to mouse superoxide dismutase (SOD1; 24-36): whole serum/R-126-100/100 µl
商品编号: R-126-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:DestroysrADIcalswhicharenormallyproducedwithinthecellsandwhicharetoxictoBIOLOGicalsystems.CATALYTICACTIVITY:2superoxide+2H+=O2+H2O2.COFACTOR:Binds1copperionpersubunit.COFACTOR:Binds1zincionpersubunit.SUBUNIT:Homodimer.SUBCELLULARLOCATION:Cytoplasm.DISEASE:DefectsinSOD1arethecauseoffamilialamyotrophiclateralsclerosis(FALS);alsocalledamyotrophiclateralsclerosis1(ALS1orALS).ALSisadegenerativedisorderofmotorneuronsinthecortex,brainstemandspinalcord.ALSischaracterizedbymuscularweaknessandatrophybeginninginthehandsandspreadingtotheforearmsandlegs.MusclefasciculationsarecommonlyvisIBLe.Sensoryabnormalitiesareabsent.Deathusuallyoccurswithin2to5years.ALSissometimesreferredtoasLouGehrigdiseaseafterthefamousAmericanbaseballplayerwhowasdiagnosedwiththedisorder.FALS,thefamilialformofALS,accountsforabout10%ofthecasesandistransmittedinanautosomaldominantmanner.ThemeanageatonsetofFALSis45years.MISCELLANEOUS:Zincbindingpromotesdimerization.SIMILARITY:BelongstotheCu-Znsuperoxidedismutasefamily.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(ASGEPVVLSGQIT)aspartofmousesuperoxidedismutase(SOD1)protein(aa:24-36)conjugatedtodiphtheriatoxoid
OtherNamesSuperoxidedismutase[Cu-Zn];SOD1
AccessionSODC_MOUSE
ProducedinRabbit
PurityWholeserum
ApplicationsWB.Adilutionof1:500to1:1000isrecommendedforthisapplication.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificitySpecificitywasconfirmedbywesternblotdetectingmousesuperoxidedismutase(SOD1).
Cross-reactivityThisantiserumisknowntoreactwithmouseandratsuperoxidedismutase(SOD1)protein.
BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
SpecificReferencesParkKHetal.(2013)PostnatalmusclemodificationbymyogenicfactorsmodulatesneuropathologyandsurvivalinanALSmousemodel.NatCommun.2013;4:2906.
GeneralReferences1.JabuschJ.R,etal.Biochemistry19:2310-2316(1980).
2.LevanonD,etal.EMBOJ.4:77-84(1985).
3.HallewellR.A,etal.NucleicAcidsRes.13:2017-2034(1985).
4.ShermanL,etal.Proc.Natl.Acad.Sci.U.S.A.80:5465-5469(1983).
5.KajiharaJ,etal.J.Biochem.104:851-854(1988).
6.AlexanderM.D,etal.Ann.Neurol.52:680-683(2002).
7.GelleraC,etal.Neuromuscul.Disord.11:404-410(2001).
8.MurakamiT,etal.J.Neurol.Sci.189:45-47(2001).
9.PencoS,etal.Neurology53:404-406(1999).
10.MoritaM,etal.Neurosci.Lett.205:79-82(1996).
11.Bartlett,etal.J.NeuroscienceMethods.98(1):63-7(2000)
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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