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当前位置: 首页 > 产品中心 > Functional_antibody > 生物传感器/兔抗ATG4B抗体(APG4B):全血清/R-157-100/100µl
商品详细生物传感器/兔抗ATG4B抗体(APG4B):全血清/R-157-100/100µl
生物传感器/兔抗ATG4B抗体(APG4B):全血清/R-157-100/100µl
生物传感器/兔抗ATG4B抗体(APG4B):全血清/R-157-100/100µl
商品编号: R-157-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:Cysteineproteaserequiredforautophagy,whichcleavestheC-terminalpartofeitherMAP1LC3,GABARAPL2orGABARAP,allowingtheliberationofformI.AsubpopulationofformIissubsequentlyconvertedtoasmallerform(formII).FormII,witharevealedC-terminalglycine,isconsideredtobethephosphatidylethanolamine(PE)-conjugatedform,andhasthecapacityforthebindingtoautophagosomes.ENZYMEREGULATION:InhibitedbyN-ethylmaleimide.SUBCELLULARLOCATION:Cytoplasm(Probable).ALTERNATIVEPRODUCTS:5namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Mainlyexpressedintheskeletalmuscle,followedbybrain,heart,liverandpancreas.SIMILARITY:BelongstothepeptidaseC54family.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(CLERFFDSEDED)correspondingtotheC-terminusofhumanATG4BproteinconjugatedtoBlueCarrierProteinhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromofATG4Bproteininmouseandrat.
OtherNamesCysteineproteaseATG4B;Autophagy-relatedprotein4homologB;hAPG4B;Autophagin-1;Autophagy-relatedcysteineendopeptidase1;AUT-like1cysteineendopeptidase;ATG4B;APG4B;AUTL1;KIAA0943;
AccessionATG4B_HUMAN
ATG4B_MOUSE
ATG4B_RAT
ProducedinRabbit
PurityWholeserum
ApplicationsIHC,immunofluorescence,WB.Adilutionof1:100to1:2000dilutionisrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityIHC,WBandELISAconfirmedthespecificityforATG4B.
Cross-reactivityHuman,rat.Otherspeciesnotyettested.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDateSixmonthsafterpurchase
SpecificReferences1.A.J.Smuderetal(2011)Exerciseprotectsagainstdoxorubicin-inducedMarkersofautophagysignalinginskeletalmuscle.JApplPhysiol.2011Jul21
References1.MarinoG,etal.J.Biol.Chem.278:3671-3678(2003).
2.KabeyaY,etal.J.CellSci.117:2805-2812(2004).
3.NagaseT,etal.DNARes.6:63-70(1999).
4.OtaT,etal.Nat.Genet.36:40-45(2004).
5.SugawaraK,etal.J.Biol.Chem.280:40058-40065(2005).
6.KumanomidouT,etal.J.Mol.Biol.355:612-618(2006).
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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