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当前位置: 首页 > 产品中心 > Functional_antibody > 生物传感器/兔抗ATG5抗体:IgG/R-138-500/500µg
商品详细生物传感器/兔抗ATG5抗体:IgG/R-138-500/500µg
生物传感器/兔抗ATG5抗体:IgG/R-138-500/500µg
生物传感器/兔抗ATG5抗体:IgG/R-138-500/500µg
商品编号: R-138-500
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:Requiredforautophagy.ConjugatestoATG12andassociateswithisolationmembranetoformcup-shapedisolationmembraneandautophagosome.Theconjugatedetachesfromthemembraneimmediatelybeforeorafterautophagosomeformationiscompleted.FUNCTION:Mayplayanimportantroleintheapoptoticprocess,possIBLywithinthemodifiedCytoskeleton.Itsexpressionisarelativelylateeventintheapoptoticprocess,occurringdownstreamofcaspaseactivity.SUBCELLULARLOCATION:Cytoplasm.Colocalizeswithnonmuscleactin.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Ubiquitous.ThemRNAispresentatsimilarlevelsinviableandapoptoticcells,whereastheproteinisdramaticallyhighlyexpressedinapoptoticcells.INDUCTION:Byapoptoticstimuli.PTM:ConjugatedtoATG12;whichisessentialforautophagy,butisnotrequiredforassociationwithisolationmembrane.SIMILARITY:BelongstotheATG5family.
BatchNo.Seeproductlabel
Unitsize500µg
AntigenAsyntheticpeptidecorrespondingtotheC-terminalofhumanATG-5L.Noimmunogeniccarrierproteinwasconjugatedtotheimmunogen.Instead,AdjukineB(seetheAdjuvantsinBiosensis"productlist)hasbeenusedtoorchestrate/boosttheimmuneresponse.
OtherNamesAutophagyprotein5;APG5-like;APG5;APG5;Apoptosis-specificprotein;ATG5;APG5L;ASP
AccessionATG5_HUMAN
ProducedinRabbit
PurityProteinGpurifiedIgG
ApplicationsFlowCytometry(2ug/10^6cells),IHC,immunofluorescence,WB.Useadilutionof1:200to1:1000fortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityIHCandwbconfirmedthespecificityforATG5.
Cross-reactivityHuman,notyettestedinotherspecies.
FormLyophilised
ReconstitutionReconstitutein500µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDateSixmonthsafterpurchase
SpecificReferences1.Garrido-MaraverJ.etal(2012)ScreeningofeffectivepharmacologicaltreatmentsforMELASsyndromeusingyeasts,fibroblastsandcybridsmodelsofthediseaseBrJPharmacol.2012Jul2.
2.DelaMataM.etal(2012)RecoveryofMERRFfibroblastsandcybridspathophysiologybyCoenzymeQ₁₀Neurotherapeutics.2012Apr;9(2):446-63.
3.CotánD.etal.(2011)SecondarycoenzymeQ10deficiencytriggersmitochondriadegradationbymitophagyinMELASfibroblastsFASEBJ.2011
References1.Mizushima,Netal.(2003)IntJBiochemCellBiol.35(5),553-61
2.BaehreckeEH.NatRevMolCellBiol.6(6):505-10.(2005)
3.LumJJ,etal.NatRevMolCellBiol.6(6):439-48.(2005)
4.GreenbergJT.DevCell.8(6):799-801.(2005)
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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