4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > 生物传感器/兔抗ATG7抗体:全血清/R-161-100/100µl
商品详细生物传感器/兔抗ATG7抗体:全血清/R-161-100/100µl
生物传感器/兔抗ATG7抗体:全血清/R-161-100/100µl
生物传感器/兔抗ATG7抗体:全血清/R-161-100/100µl
商品编号: R-161-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:FunctionsasanE1enzymeessentialformultisubstratessuchasGABARAPL1andATG12.FormsintermediateconjugateswithGABARAPL1(GABARAPL2,GABARAPorMAP1ALC3).FormationofthefinalGABARAPL1-PEconjugateisessentialforautophagy.SUBUNIT:Homodimer(Bysimilarity).InteractswithATG3andATG12.Thecomplex,composedofATG3andATG7,playsaroleintheconjugationofATG12toATG5.SUBCELLULARLOCATION:Cytoplasm(Probable).ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Widelyexpressed,especiallyinkidney,liver,lymphnodesandbonemarrow.DOMAIN:TheC-terminalpartoftheproteinisessentialforthedimerizationandinteractionwithATG3andATG12.SIMILARITY:BelongstotheATG7family.Inyeast,ATG7appearstoberequiredforfusionofperoxisomalandvaculuolarmembranes.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(DSTRDRTLDQQC)correspondingtotheC-terminalofhumanAPG7proteinconjugatedtobluecarrierproteinhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromAPG7proteininmouse,rat,S.cerevisiae,Macacamulatta(monkey)andCanisfamiliaris(dog).
OtherNamesAutophagy-relatedprotein7;Ubiquitin-activatingenzymeE1-likeprotein;hAGP7;APG7-like;ATG7;APG7L
AccessionATG7_HUMAN
ATG7_MOUSE
ATG7_RAT
ATG7_Saccharomycescerevisiae
ATG7_Macacamulatta
ATG7_Canisfamiliaris
ProducedinRabbit
PurityWholeserum
ApplicationsNon-reducedwesternblot:1:100;IF:acetoneor3.7%PFAfixedcells(HJLimetal2013);1:100;Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityIF,WBandELISAconfirmedthespecificityforATG7.
Cross-reactivityHuman,rat.Otherspeciesnotyettested.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageStorelyophilizedantibodyat2-8ºC.Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferencesChiu-WeiChen,etal(2012)Inhibitionofautophagyasatherapeuticstrategyofiron-inducedbraininjuryafterhemorrhageAutophagy,8(10):1510.
ChienW.S.etal(2011)SuppressionofautophagyinratliveratlatestageofpolymicrobialsepsisShock.2011Jan14
LeeJ.E.etal(2011)AutophagyRegulatesEmbryonicSurvivalDuringDelayedImplantationEndocrinology.2011Mar1.
RyningenAetal(2012)InhibitionofMammaliantargetofrapamycininhumanacutemyeloidleukemiacellshasdiverseeffectsthatdependontheenvironmentalinvitrostress.BoneMarrowRes.2012;2012:329061.
OhHAetal(2013)Uncoveringaroleforendocannabinoidsignalinginautophagyinpreimplantationmouseembryos.MolHumReprod.2013Feb;19(2):93-101.
References1.YuanW,etal.Mol.Biol.Cell10:1353-1366(1999).
2.TanidaI,etal.Biochem.Biophys.Res.Commun.292:256-262(2002).
3.TanidaI,etal.J.Biol.Chem.277:13739-13744(2002).
4.MizushimaN,etal.Nature395:395-398(1998).
5.JohnstonM,etal.Science265:2077-2082(1994).
6.HardingT.M,etal.J.CellBiol.131:591-602(1995).
7.KimJ,etal.Mol.Biol.Cell10:1337-1351(1999).
8.KomatsuM,etal.J.Biol.Chem.276:9846-9854(2001).
9.KlionskyD.J,etal.Dev.Cell5:539-545(2003).
10.chimuraY,etal.J.Biol.Chem.279:40584-40592(2004).
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616