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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit polyclonal antibody to human Matrix Metalloproteinase 2 (MMP2, 475-490): Affinity Purified/R-1381-100/100 µg
商品详细Biosensis/Rabbit polyclonal antibody to human Matrix Metalloproteinase 2 (MMP2, 475-490): Affinity Purified/R-1381-100/100 µg
Biosensis/Rabbit polyclonal antibody to human Matrix Metalloproteinase 2 (MMP2, 475-490): Affinity Purified/R-1381-100/100 µg
Biosensis/Rabbit polyclonal antibody to human Matrix Metalloproteinase 2 (MMP2, 475-490): Affinity Purified/R-1381-100/100 µg
商品编号: R-1381-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionUbiquitinousmetalloproteinasethatisinvolvedindiversefunctionssuchasremodelingofthevasculature,angiogenesis,tissuerepair,tumorinvasion,inflammation,andatheroscleroticplaquerupture.AswellasdegrADIngextracellularmatrixproteins,canalsoactonseveralnonmatrixproteinssuchasbigendothelial1andbeta-typeCGRPpromotingvasoconstriction.AlsocleavesKISSataGly-|-Leubond.Appearstohavearoleinmyocardialcelldeathpathways.ContributestomyocardialoxidativestressbyregulatingtheactivityofGSK3beta.CleavesGSK3betainvitro.InvolvedintheformationofthefibrovasculartissuesinassociationwithMMP14.PEX,theC-terminalnon-catalyticfragmentofMMP2,possesesanti-angiogenicandanti-tumorpropertiesandinhibitscellmigrationandcelladhesiontoFGF2andvitronectin.Ligandforintegrinv/beta3onthesurfaceofbloodvessels.MMP2isoform2mediatestheproteolysisofCHUK/IKKAandinitiatesaprimaryinnateimmuneresponsebyinducingmitochondrial-nuclearstresssignalingwithactivationofthepro-inflammatoryNF-kappaB,NFATandIRFtranscriptionalpathways.CatalyticactivityofMMP2causescleavageofgelatintypeIandcollagentypesIV,V,VII,X.Cleavesthecollagen-likesequencePro-Gln-Gly-|-Ile-Ala-Gly-Gln.(Ref:uniprot.org).
BatchNo.Seeproductlabel.
Unitsize100µg
AntigenHumanC-terminalpeptide(aminoacids475-490).
AntibodyTypePolyclonal.
IsotypeIgG
OtherNames72kDagelatinase;GelatinaseA;MMP-2;TBE-1
AccessionP08253MMP2_HUMAN;
ProducedinRabbit
PurityAffinitypurified.
ApplicationsWesternBlotting(WB):1:5,000-1:10,000.MMP2appearsastwobandsatapparentmolecularweightsof66and72kDa.

Immunohistochemistry(IHC):1:500-1:1,000.

Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityHuman.
Cross-reactivityExpectedtoreactwithhorse,cow,pig,chicken,ratandmouseMMP2.
FormLyophilisedfromPBSpH7.4,containing3%trehalose,withoutpreservatives.
ReconstitutionReconstitutewith100µLsterile-filtered,ultrapurewater,toachieveanantibodyconcentrationof1mg/mL.Centrifugebrieflytoremoveanyinsolublematerial.
StorageStorelyophilised,unopenedvialat2-8°Corlower.Afterreconstitution,preparealiquotsandstoreat-20°Cto-80°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase(unopenedvial).
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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