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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/抗磷酸钙/钙调素依赖性蛋白激酶II型亚单位α(α-CaMKII,Thr253)的兔抗体
商品详细Biosensis/抗磷酸钙/钙调素依赖性蛋白激酶II型亚单位α(α-CaMKII,Thr253)的兔抗体
Biosensis/抗磷酸钙/钙调素依赖性蛋白激酶II型亚单位α(α-CaMKII,Thr253)的兔抗体
Biosensis/抗磷酸钙/钙调素依赖性蛋白激酶II型亚单位α(α-CaMKII,Thr253)的兔抗体
商品编号: R-1706-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionCalcium/calmodulin-stimulatedproteinkinaseII(CaMKII)iscomposedoffourdifferentchains(alpha,beta,gamma,anddelta)andisabundantlyexpressedinneurons.CaMKIIisinvolvedinregulatingmanyaspectsofneuronalfunction,includingneurotransmittersynthesisandrelease,modulationofionchannelactivityandcellulartransport.TheenzymaticfunctionofCaMKIIisregulatedbyitsmultiplephosphorylationsitesandtargetingtosub-cellularlocationsthroughinteractionswithproteinbindingpartners.PhosphorylationofThr253hasbeenidentifiedinvivoandfoundtoaltertheinteractionofCaMKIIwithbindingpartners,butnotchangeitsenzymaticactivity.Thus,phosphorylationofThr253issuggestedtomodulatefunctionalresponsesbasedonitsbindingpartnerandsubsequentlyitssub-cellularlocalization.
BatchNo.Seeproductlabel
Unitsize100uL
AntigenAsyntheticpeptide(NKMLpTINPSC)correspondingtothesequencearoundThr253(AA249-257)inalpha-CaMKIIwassynthesized,purifiedto95%puritybyHPLC,analyzedbymassspectroscopyandcoupledtodiphtheriatoxoid.
AntibodyTypePolyclonal
AccessionP11275KCC2A_RAT
ProducedinRabbit
PurityWholeserum
ApplicationsWesternBlotting(1:200–1:1000).Otherapplicationshavenotbeentested.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityRat
Cross-reactivityNottested.Predictedfromgeneanalysistoreactwithhumanandmousealpha-CaMKII.
FormLyophilized
ReconstitutionReconstitutein100uLsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferences1.SkeldingKAetal(2012)JJCerebBloodFlowMetab32(12),2181-2192.
2.SkeldingKAetal(2010)CellSignal22(5),759-769.
3.GurdJWetal(2008)BrainRes1218,158-165.
4.MiguesPVetal(2006)JNeuRochem98(1),289-299.
GeneralReferences1.SkeldingKAet(2011)CellCycle10(4),631-639.
2.DosemeciA&JaffeH(2010)BiochemBiophysResCommun391(1),78-84.
3.SkeldingKA&RostasJAP(2009)NeurochemRes34,1792-1804.
4.Dosemeci,A.etal(1994)JBiolChem269(50),31330-31333.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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