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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Mouse monoclonal antibody to rh c-FOS: Affinity purified/M-1752-100/100 µg
商品详细Biosensis/Mouse monoclonal antibody to rh c-FOS: Affinity purified/M-1752-100/100 µg
Biosensis/Mouse monoclonal antibody to rh c-FOS: Affinity purified/M-1752-100/100 µg
Biosensis/Mouse monoclonal antibody to rh c-FOS: Affinity purified/M-1752-100/100 µg
商品编号: M-1752-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:Nuclearphosphoproteinwhichformsatightbutnon-covalentlylinkedcomplexwiththeJUN/AP-1transcriptionfactor.Intheheterodimer,FOSandJUN/AP-1basicregionseachseemstointeractwithsymmetricalDNAhalfsites.OnTGF-betaactivation,formsamultimericSMAD3/SMAD4/JUN/FOScomplexattheAP1/SMAD-bindingsitetoregulateTGF-beta-mediatedsignaling.Hasacriticalfunctioninregulatingthedevelopmentofcellsdestinedtoformandmaintaintheskeleton.Itisthoughttohaveanimportantroleinsignaltransduction,cellproliferationanddifferentiation.Ingrowingcells,activatesphospholipidsynthesis,possIBLybyactivatingCDS1andPI4K2A.ThisactivityrequiresTyr-dephosphorylationandassociationwiththeendoplasmicreticulum.SUBUNIT:Heterodimer.InteractswithDSIPI;thisinteractioninhibitsthebindingofactiveAP1toitstargetDNA.InteractswithMAFB.SUBCELLULARLOCATION:Nucleus.INDUCTION:C-fosexpressionincreasesuponavarietyofstimuli,includinggrowthfactors,cytokines,neurotransmitters,polypeptidehormones,stressandcellinjury.SIMILARITY:BelongstothebZIPfamily.Fossubfamily.SIMILARITY:Contains1bZIPdomain(Ref:uniprot.org).
BatchNo.Seeproductlabel.
Unitsize100µg
AntigenFulllength,E.coli-derivedrecombinanthumanc-FOSprotein.
AntibodyTypeMonoclonal
IsotypeIgG1
OtherNamesCellularoncogenefos;G0/G1switchregulatoryprotein7;cFOS
AccessionFOS_HUMAN
ProducedinMouse.
PurityAffinitypurified.
ApplicationsImmunohistochemistry(IHC)andimmunocytochemistry(ICC):1-2µg/mL.Thisantibodyhasbeenshowntoworkon4%PFAfixedmousebrainsections.

Westernblotting(WB):0.5-1.0µg/mL.Thisantibodydetectsbandsbetween50-65kDa,whichonlyappearinstimulatedcells.

Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityHuman.
Cross-reactivityHorse,cow,pig,chicken,rat,mouse.
BlastURLClickhere
FormLyophilizedfromasolutioncontaining3%trehaloseinPBS,pH7.4,withoutpreservatives.
ReconstitutionReconstitutewith100µLsterile-filtered,ultrapurewater,toachieveanantibodyconcentrationof1mg/mL.Centrifugebrieflytoremoveanyinsolublematerial.
StorageStorelyophilised,unopenedvialat2-8°Corlower.Afterreconstitution,preparealiquotsandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchaseifunopenedandstoredasindicated.
GeneralReferencesVanstrAATenetal(1983)Proc.Natl.Acad.Sci.80:3183(Originalmolecularc-fossequencepaper)

MinsonJ.etal.(1994)BrainRes.646:44-52(EarlyIHClocalizationpaper)
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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