Biosensis/兔抗rh c-FOS多克隆抗体：亲和纯化/R-1751-50/50µg
商品编号：
R-1751-50
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB. SUBCELLULAR LOCATION: Nucleus. INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. SIMILARITY: Belongs to the bZIP family. Fos subfamily. SIMILARITY: Contains 1 bZIP domain (Ref: uniprot.org). |
| Batch No. | See product label. |
| Unit size | 50 µg |
| Antigen | Full length, E.coli-derived recombinant human c-FOS protein. |
| Antibody Type | Polyclonal. |
| Other Names | Cellular oncogene fos; G0/G1 switch regulatory protein 7; cFOS |
| Accession | FOS_HUMAN |
| Produced in | Rabbit. |
| Purity | Affinity purified. |
| Applications | Immunohistochemistry (IHC) and immunocytochemistry (ICC): 0.2-1.0 µg/mL. This antibody has been shown to work on 4% PFA fixed mouse brain sections. Western blotting (WB): 0.5-1.0 µg/mL. This antibody detects bands between 50-65 kDa, which only appear in stimulated cells. Biosensis recommends optimal dilutions/concentrations should be determined by the end user. |
| Specificity | Human. |
| Cross-reactivity | Horse, cow, pig, chicken, rat, mouse. |
| Blast URL | Click here |
| Form | Lyophilized from a solution containing 3% trehalose in PBS, pH 7.4, without preservatives. |
| Reconstitution | Reconstitute with 50 µL sterile-filtered, ultrapure water, to achieve an antibody concentration of 1 mg/mL. Centrifuge briefly to remove any insoluble material. |
| Storage | Store lyophilised, unopened vial at 2- 8°C or lower. After reconstitution, prepare aliquots and store at -20°C for a higher stability. Avoid freeze-thaw cycles. |
| Expiry Date | 12 months after purchase if unopened and stored as indicated. |
| General References | Vanstraaten et al (1983) Proc. Natl. Acad. Sci. 80: 3183 (Original molecular c-fos sequence paper) Minson J. et al. (1994) Brain Res. 646: 44-52 (Early IHC localization paper) |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
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神经营养因子
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电话：PE-1239-5
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2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
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PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
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感觉神经系统
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TR-100-FJ
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神经内分泌
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PE-1243-25
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自噬
PE-1242-2型
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神经递质和酶
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神经元标志物
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BL-004-500型
PE-019-25
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受体体嵌合体
信令与转录
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BL-001-1250型
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PE-019-500
干细胞
连接蛋白
TR-300-AG型
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发展
阿尔茨海默氏症/帕金森氏症
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