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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to Orexin A (14-33): whole serum/R-104-100/100 µl
商品详细Biosensis/Rabbit antibody to Orexin A (14-33): whole serum/R-104-100/100 µl
Biosensis/Rabbit antibody to Orexin A (14-33): whole serum/R-104-100/100 µl
Biosensis/Rabbit antibody to Orexin A (14-33): whole serum/R-104-100/100 µl
商品编号: R-104-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:Neuropeptidesthatplayasignificantroleintheregulationoffoodintakeandsleep-wakefulness,possIBLybycoordinatingthecomplexbehavioralandphysiologicresponsesofthesecomplementaryhomeostaticfunctions.Abroaderroleinthehomeostaticregulationofenergymetabolism,autonomicfunction,hormonalbalanceandtheregulationofbodyfluids,isalsosuggested.Orexin-AbindstobothOX1RandOX2Rwithahighaffinity,whereasorexin-BbindsonlytoOX2Rwithasimilarhighaffinity.SUBCELLULARLOCATION:Endoplasmicreticulum;roughendoplasmicreticulum.Associatedwithperikaryalroughendoplasmicreticulumaswellascytoplasmiclargegranularvesiclesatsynapses.SIMILARITY:Belongstotheorexinfamily.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(CRLYELLHGAGNHAAGILTL)aspartofBovineOrexinA(aa:14-33)conjugatedtoKLHhasbeenusedastheimmunogen.
AntigenLocation14-33aa
OtherNamesOrexin-A;Hypocretin-1;Hcrt1
AccessionOREX_BOVIN
ProducedinRabbit
PurityWholeserum
ApplicationsIHC.ThisisasuperbantiserumforimmunohistochemistryonOrexinAcontainingneuronsexhibitingintenselabellingofneuronswithverylowbackground.Adilutionof1:1000to1:2000isrecommendedforthisapplication.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThespecificityforthisantiserumhasbeenconfirmedbyimmunohistochemistryonratbrainandtheresultsreflectthecurrentliterature.
Cross-reactivityThisantibodyisknowntoreactwithratOrexinA.
BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferences1.KrugerJ.L.etal(2010)Cellularlocationandmajorterminalnetworksoftheorexinergicsysteminthebrainsoffivemicrochiropteranspecies.JChemNeuroanat.2010Nov;40(3):256-62.
2.GaykemaR.P.etal(2009)Lipopolysaccharidechallenge-inducedsuppressionofFosinhypothalamicorexinneurons:theirpotentialroleinsicknessbehavior.BrainBehavImmun.2009Oct;23(7):926-30.
3.LeeH.S.etal(2005)Retrogradestudyofhypocretin-1(orexin-A)projectionstosuBDivisionsofthedorsalraphenucleusintherat.BrainRes.2005Oct12;1059(1):35-45.
4.YaoS.T.etal(2005)Waterdeprivationincreasestheexpressionofneuronalnitricoxidesynthase(nNOS)butnotorexin-Ainthelateralhypothalamicareaoftherat.JCompNeurol.2005Sep19;490(2):180-93.
ReferencesNambu,T.etal.(1999)BrainResearch.827:243-60
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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