4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/针对酪氨酸激酶受体B(TrkB)的兔抗体:全血清/R-149-100/100µl
商品详细Biosensis/针对酪氨酸激酶受体B(TrkB)的兔抗体:全血清/R-149-100/100µl
Biosensis/针对酪氨酸激酶受体B(TrkB)的兔抗体:全血清/R-149-100/100µl
Biosensis/针对酪氨酸激酶受体B(TrkB)的兔抗体:全血清/R-149-100/100µl
商品编号: R-149-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionTrkBisamemberoftheneurotrophictyrosinereceptorkinasefamily.Itisamembrane-boundreceptoranduponneurotrophinbinding,itphosphorylatesitselfaswellasMAPKpathwaysmembers.TrkBisthereceptorforbrain-derivedneurotrophicfactor(BDNF),neurotrophin-3andneurotrophin-4/5butnotnervegrowthfactor(NGF).ItisInvolvedinthedevelopmentand/ormaintenanceofthenervoussystem.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures. SUBCELLULARLOCATION:Membrane;single-passtypeImembraneprotein.ALTERNATIVEPRODUCTS:4namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.TISSUESPECIFICITY:Thedifferentformsaredifferentiallyexpressedinvariouscelltypes.SIMILARITY:BelongstotheTyrproteinkinasefamily.Insulinreceptorsubfamily.SIMILARITY:Contains2Ig-likeC2-type(immunoglobulin-like)domains.SIMILARITY:Contains2LRR(leucine-rich)repeats.SIMILARITY:Contains1proteinkinasedomain.MutationsintheTrkBgenehavebeenassociatedwithobesityandmooddisorders.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenExtracellulardomainofglycosylatedmouseTrkBproteinproducedinCHOcellswasusedastheimmunogen.Asshownforsimilarantisera,itisanticipatedthatthisantibodywillblocktheTrkBreceptorbindingofcorrespondingneurotrophinligand.
OtherNamesTropomyosin-relatedkinasereceptor;BDNF/NT-3growthfactorsreceptor;Neurotrophictyrosinekinasereceptortype2;TrkBtyrosinekinase;GP145-TrkB/GP95-TrkB;Trk-B;Ntrk2
AccessionNTRK2_MOUSE
ProducedinRabbit
PurityWholeserum
ApplicationsIF(1:1000-1:3000),1-siteELISA(1:10,000dilution).Adilutionof1:1000to1:3000o/nisrecommendedforIF.4%PFAfrozensectionstested.Notyettestedonparaffinembeddedtissues.UsetritonX-100permeABIlizaitonwithfrozensections.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificitySpecificitywasdemonstratedbyimmunohistochemistry.Thisantibodywasusedtostaincryostatsectionsoftheratperipheralsensoryganglia.
Cross-reactivityReactswithratandmouseTrkB.Otherspecieshavenotyetbeentested.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20°Cforahigherstability,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
SpecificReferencesPenzoMA,etal(2015)Theparaventricularthalamuscontrolsacentralamygdalafearcircuit.NatureJan192015[Eprint]Appl:IF,speciesmouse,4%PFA,>2hrfixation,frozensections
GeneralReferencesDesmetCJ,PeeperDS(2006)CellMolLifeSci.63(7-8)pp.755-9
MizoguchiYetal.,JImmunol.2009Dec15;183(12):7778-86.
Spencer-SegalJLetal.JNeurosci.2011May4;31(18):6780-90.
NakajimaKetal.Glia.1998Nov;24(3):272-89.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616