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Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor B (TrkB; 23-36): whole serum/R-121-100/100 µl
Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor B (TrkB; 23-36): whole serum/R-121-100/100 µl
商品编号：
R-121-100
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | FUNCTION:Receptorforbrain-derivedneurotrophicfactor(BDNF),neurotrophin-3andneurotrophin-4/5butnotnervegrowthfactor(NGF).Involvedinthedevelopmentand/ormaintenanceofthenervoussystem.Thisisatyrosine-proteinkinasereceptor.KnownsubstratesfortheTRKreceptorsareSHC1,PI-3kinase,andPLC-gamma-1.CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures(Bysimilarity).BindsAPS.InteractswithSQSTM1.SUBCELLULARLOCATION:Membrane;single-passtypeImembraneprotein.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.TISSUESPECIFICITY:Thedifferentformsaredifferentiallyexpressedinvariouscelltypes.IsoformT2isprimarilyexpressedinneurons.PTM:Ligand-mediatedauto-phosphorylation.SIMILARITY:BelongstotheTyrproteinkinasefamily.Insulinreceptorsubfamily.SIMILARITY:Contains2Ig-likeC2-type(immunoglobulin-like)domains.SIMILARITY:Contains2LRR(leucine-rich)repeats.SIMILARITY:Contains1proteinkinasedomain. |
| Relatedproducts | TrkBcontrolpeptide(aa:23-36),PE-1252-100 |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(AFPRLEPNSIDPENC)aspartofratmatureTrkBprotein(aa:23-36)conjugatedtoKLH |
| OtherNames | Tropomyosin-relatedkinasereceptor;BDNF/NT-3growthfactorsreceptor;Neurotrophictyrosinekinasereceptortype2;TrkBtyrosinekinase;GP145-TrkB/GP95-TrkB;Trk-B;Ntrk2;Trkb |
| Accession | NTRK2_RAT |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC.Adilutionof1:1000to1:3000isrecommendedforthisapplication.ForWB,a1:500to1:1000dilutionisrecommended.ThesequenceoftheimmunogenandtheconjugateareidenticaltotheoneusedbyYanetal(seetheRefs)andtheantiserumappearstohavesimilarcharacteristics.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SequencewaschosentoavoidcrossreactivitywithTrkAandTrkC. |
| Cross-reactivity | Thisantiserumrecogniseshuman,ratandmouseTrkB.Crossreactivitywithotherspecieshasnotyetbeentested. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | WangT,MartinS,NguyenTH,HarperCB,GormalRS,Martínez-MármolR,KarunanithiS,CoulsonEJ,GlassNR,Cooper-WhiteJJ,vanSwinderenB,MeunierFA.(2016)"FluxofsignallingendosomesundergoingaxonalretrogradetransportisencodedbypresynapticactivityandTrkB."NatCommun.2016Sep.PMID:2768712930(7):12976.Application:IF&structuredIlluminationmicroscopy(SIM).Species:Rat,Mouse;fixed4%PFAwith4%sucrose MatusicaDetal(2016)Inhibitionofmotorneurondeathinvitroandinvivobyap75neurotrophinreceptorintracellulardomainfragment.JCellSci.2016Feb1;129(3):517-30.Application:WB. BrockJHetal(2010)Localandremotegrowthfactoreffectsafterprimatespinalcordinjury.JNeurosci.2010Jul21;30(29):9728-37. GruberH.etal(2008)Brain-derivedneurotrophicfactoranditsreceptorinthehumanandthesandratintervertebraldisc.ArthritisResTher.2008;10(4):R82. |
| References | 1.YanQetal.JCompNeurol378:135-57(1997). 2.Stoilov,P.,etal.,Biochem.Biophys.Res.Commun.290(3):1054-1065(2002). 3.Strausberg,R.L.,etal.,Proc.Natl.Acad.Sci.U.S.A.99(26):16899-16903(2002). 4.Nakagawara,A.,etal.,Genomics25(2):538-546(1995). 5.Haniu,M.,etal.,Arch.Biochem.Biophys.322(1):256-264(1995). 6.Allen,S.J.,etal.,Neuroscience60(3):825-834(1994). 7.MizoguchiYetal.,JImmunol.2009Dec15;183(12):7778-86. 8.Spencer-SegalJLetal.JNeurosci.2011May4;31(18):6780-90. 9.NakajimaKetal.Glia.1998Nov;24(3):272-89. |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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