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Biosensis/Rabbit antibody to BDNF (129-138): whole serum/R-083-100/100 µL
Biosensis/Rabbit antibody to BDNF (129-138): whole serum/R-083-100/100 µL
商品编号：
R-083-100
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | BDNFbelongstotheneurotrophinfamilyandregulatesthesurvivalanddifferentiationofneuronsduringdevelopment.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"s,andParkinson"sdisease.MicrogliareleaseBDNFthatmaycontributetoneuroinflammationandneuropathicpain.FUNCTION:Promotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.MajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.POsttranslationmodification:ConvertedintomatureBDNFbyplasmin(PLG).SIMILARITY:BelongstotheNGF-betafamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µL |
| Antigen | Asyntheticpeptide(HSDPARRGEL)asapartofhumanBDNFprotein(aa:129-138)conjugatedtoKLHhasbeenusedastheimmunogen.TheBDNFproteinsequenceishighlyconservedamongstprimates. |
| OtherNames | Brain-derivedneurotrophicfactor;Abrineurin;proBDNF; |
| Accession | BDNF_HUMAN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | WesternBlotting:ThisantibodydetectsmultipleBDNFisoforms(14kDamatureBDNF,18kDaisoform,28kDaBDNFdimer/truncatedBDNF,32kDaproBDNFmonomer)dependingonsampleapplication(humanserum,celllysate,tissuehomogenate).AntibodyalsodetectsBDNFundernon-reducingconditions(McLeanNA,2014). ELISA:Detectiononly,1:1000-1:5000recommended. Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Lessthan0.1%crossreactivitywithmouseNGF,recombinanthumanNT3andNT4/5hasbeenrecordedbydotblotanalysis. |
| Cross-reactivity | Thisantiserumisknowntorecogniserat,mouseandhumanBDNF,andisexpectedtoreactwithBDNFfromotherspeciesduetoaminoacidsequencehomology. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µLofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | McLeanNA,PopescuBF,GordonT,ZochodneDW,VergeVM.(2014)"Delayednervestimulationpromotesaxon-protectiveneurofilamentphosphorylation,acceleratesimmunecellclearanceandenhancesremyelinationinvivoinfocallydemyelinatednerves."PLoSOne.2014Oct13;9(10):e110174Application:WB,non-reducing,Species:Rat CysneirosR.M.etal(2010)Qualitativeanalysisofhippocampalplasticchangesinratswithepilepsysupplementedwithoralomega-3fattyacidsEpilepsyBehav.2010Jan;17(1):33-8. OoeN.etal(2009)DynamicregulationofbHLH-PAS-typetranscriptionfactorNXFgeneexpressionandneurotrophindependentinductionofthetranscriptionalcontrolactivityBiochemBiophysResCommun.2009Jan23;378(4):761-5. |
| GeneralReferences | 1.AAchesonetal(1995)Nat.74:450-3 2.QYanetal(1994)J.Neurosci.14(9):5281-91 3.XFZhouetal(1996)Neurosci.74:945-53 4.XFZhou,etal(1998)Exp.Neurol.149:237-42 5.BMellstrometal(2004)CritRevNeurobiol16,43-9 6.ITapia-Arancibiaetal(2004)FrontNeuroendocrinol25,77-107 7.SPezet,etal(2002)BrainResBrainResRev40,240-9 8.BardeY.A.etal(1989)EMBOJ.1:549 9.ConnerJetal.(1997)J.Neurosci.17:2295 10.JACoulletal(2005)Nature.Dec15;438(7070):1017-21. 11.CGomesetal(2013)JNeuroinflammation.Jan30;10:16. |
| References | BDNFAntibodiesforWesternBlotting |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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