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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to proBDNF (69-82): affinity purified/R-176-20/20 µg
商品详细Biosensis/Rabbit antibody to proBDNF (69-82): affinity purified/R-176-20/20 µg
Biosensis/Rabbit antibody to proBDNF (69-82): affinity purified/R-176-20/20 µg
Biosensis/Rabbit antibody to proBDNF (69-82): affinity purified/R-176-20/20 µg
商品编号: R-176-20
品牌: Biosensis inc
市场价: ¥4540.00
美元价: 2724.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionBDNFbelongstotheneurotrophinfamilyandpromotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.ItisamajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"s,andParkinson"sdisease.MicrogliareleaseBDNFthatmaycontributetoneuroinflammationandneuropathicpain.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.Posttranslationmodification:ConvertedintomatureBDNFbyplasmin(PLG).SIMILARITY:BelongstotheNGF-betafamily.
BatchNo.Seeproductlabel
Unitsize20µg
AntigenAsyntheticpeptide(C-ELLDEDQKVRPNEE)asapartofhumanBDNFprecursorprotein(aa:69-82)conjugatedtoKLHhasbeenusedastheimmunogen.
OtherNamesBrain-derivedneurotrophicfactor(Precursor);Abrineurin
AccessionBDNF_HUMAN
ProducedinRabbit
PurityAffinitypurified
ApplicationsIHC,WB.1-5µg/mlisrecommendedforbothapplications,FlowCytometry(2ug/10^6cells).Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
CommentsReady-to-usereagentsforin-vitrolaboratoryresearchuseonly.
SpecificityUsedinwesternblot,thisantiserumdetectsa35kDabandcorrespondingtothemolecularweightofproBDNF.Nocrossreactivitywithotherproneurotrophinswasdetected.
Cross-reactivityThisantibodyisknowntoreactwithhuman,mouseandratproBDNFandalsoexpectedtorecogniseothermammalianproBDNF.
BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.
FormLyophilised
ReconstitutionReconstitutein20µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferences1.MaciasM.etal(2007)Locomotorexercisealtersexpressionofpro-brain-derivedneurotrophicfactor,brain-derivedneurotrophicfactoranditsreceptorTrkBinthespinalcordofadultrats.EurJNeurosci.2007Apr;25(8):2425-44.
References1.AAchesonetal(1995)Nat.74:450-3
2.QYanetal(1994)J.Neurosci.14(9):5281-91
3.XFZhouetal(1996)Neurosci.74:945-53
4.XFZhou,etal(1998)Exp.Neurol.149:237-42
5.BMellstrometal(2004)CritRevNeurobiol16,43-9
6.ITapia-Arancibiaetal(2004)FrontNeuroendocrinol25,77-107
7.SPezet,etal(2002)BrainResBrainResRev40,240-9
8.BardeY.A.etal(1989)EMBOJ.1:549
9.ConnerJetal.(1997)J.Neurosci.17:2295
10.LUlmanetal(2008)JNeurosci.Oct29;28(44)
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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