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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/抗BDNF(129-148)的兔多克隆抗体:亲和纯化/R-1004-100/100µg
商品详细Biosensis/抗BDNF(129-148)的兔多克隆抗体:亲和纯化/R-1004-100/100µg
Biosensis/抗BDNF(129-148)的兔多克隆抗体:亲和纯化/R-1004-100/100µg
Biosensis/抗BDNF(129-148)的兔多克隆抗体:亲和纯化/R-1004-100/100µg
商品编号: R-1004-100
品牌: Biosensis inc
市场价: ¥6540.00
美元价: 3924.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionBDNFbelongstotheneurotrophinfamilyandpromotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.ItisamajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycaemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"s,andParkinson"sdisease.MicrogliareleaseBDNFthatmaycontributetoneuroinflammationandneuropathicpain.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.Posttranslationmodification:ConvertedintomatureBDNFbyplasmin(PLG).SIMILARITY:BelongstotheNGF-betafamily.
BatchNo.Seeproductlabel
Unitsize100µg
AntigenApeptide(HSDPARRGELSVCDSISEWV)correspondingtoasequenceattheN-terminalofhumanBDNF(aminoacids129-148).
OtherNamesBrain-derivedneurotrophicfactor;Abrineurin;proBDNF;
AccessionP23560BDNF_HUMAN;P21237BDNF_MOUSE;P23363BDNF_RAT
ProducedinRabbit
PurityAffinitypurifiedonantigencolumn
ApplicationsWesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanBDNFhasapredictedlengthof247residuesandMWof28kDaforBDNFprecursorand13kDaformatureBDNF.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThespecificityofthisantibodyhasbeenconfirmedbyWBagainsttheantigen.
Cross-reactivityHuman;mouse;rat;
BlastitIfyouwishtousethisproductinaspeciesotherthanthosespecifiedhereandwanttodeterminetheaminoacidsequencehomologybetweentheimmunogenandthecorrespondingproteininthatspecies,simplycopytheaminoacidsequenceforthisimmunogenandtestitontheBLASTdatabasethatyoucanaccessthroughthelinkbelow.Pleasenotethatantibodiesraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptide.Whatthismeansinpractiseisthatasingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.TheBLASTdatabasecanalsobeusedtocompareanyaminoacidsequencebetweenspeciesandbetweenprotein.ThefullaminoacidsequenceofthetargetproteincanbefoundbyfollowingthelinkintheAccessionfield.YoucanthensearchanyaminoacidsequenceinthetargetproteinusingtheBLASTdatabase.Whenselectingasequencetosearch,pleasechosecarefully,asthesequenceyouchosemaybeaprecursorratherthanthematureproteinforexample.
FormLyophilized
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageMaintainlyophilizedmaterialat-20°Cforupto12monthsafterdateofreceipt.Afterreconstitution,aliquotandstoreat-20°Cforupto6months.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase,unopened.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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