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Biosensis/Rabbit polyclonal antibody to human Myeloperoxidase (714-728): Affinity purified/R-1073-100/100 µg
Biosensis/Rabbit polyclonal antibody to human Myeloperoxidase (714-728): Affinity purified/R-1073-100/100 µg
商品编号：
R-1073-100
品牌：
Biosensis inc
市场价：
¥6540.00
美元价：
3924.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | FUNCTION:Partofthehostdefensesystemofpolymorphonuclearleukocytes.ItisresponsIBLeformicrobicidalactivityagainstawiderangeoforganisms.InthestimulatedPMN,MPOcatalyzestheproductionofhypohalousacids,primarilyhypochlorousacidinphysiologicsituations,andothertoxicintermediatesthatgreatlyenhancePMNmicrobicidalactivity.MPOisanimportantMarkerformyeloidcells,fromthepromyelocytestageandtothematureforms.CATALYTICACTIVITY:Donor+H2O2=oxidizeddonor+2H2O.CATALYTICACTIVITY:Cl-+H2O2=HOCl+2H2O.COFACTOR:Binds1calciumionperheterodimer.COFACTOR:Binds1hemeB(iron-protoporphyrinIX)groupcovalentlyperheterodimer.SUBUNIT:Tetrameroftwolightchainsandtwoheavychains.SUBCELLULARLOCATION:Lysosome.ALTERNATIVEPRODUCTS:Atleast3namedisoformsproducedbyalternativesplicing.DISEASE:DefectsinMPOarethecauseofmyeloperoxidasedeficiency(MPD).MPDisanautosomalrecessivedefectthatresultsindisseminatedcandidiasis.SIMILARITY:Belongstotheperoxidasefamily.XPOsubfamily.MicrogliaandastrocytesareknowntoexpressMPOaswell. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Asyntheticpeptide(KNNIFMSNSYPRDFV)correspondingtoaregion(714-728)attheC-terminusofhumanMyeloperoxidase(MPO). |
| OtherNames | MPO;EC1.11.1.7;Myeloperoxidase; |
| Accession | P05164PERM_HUMAN; |
| Producedin | Rabbit |
| Purity | Affinitypurifiedonantigencolumn |
| Applications | Immunohistochemistry(IHC)andWesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanMPO(isoformH17)hasapredictedlengthof745residuesandMWof84kDa.Aconcentrationof0.5-1.0µg/mlisrecommendedtodetecttheproteininformalin/paraffinembeddedtissues.Heatmediatedantigenretrievalin10mMcitratebuffer,pH6.0for20minutesisrequired.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWBandIHCagainsttheantigen. |
| Cross-reactivity | Human;rat;predictedtoreactwithmouse |
| Blastit | Ifyouwishtousethisproductinaspeciesotherthanthosespecifiedhereandwanttodeterminetheaminoacidsequencehomologybetweentheimmunogenandthecorrespondingproteininthatspecies,simplycopytheaminoacidsequenceforthisimmunogenandtestitontheBLASTdatabasethatyoucanaccessthroughthelinkbelow.Pleasenotethatantibodiesraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptide.Whatthismeansinpractiseisthatasingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.TheBLASTdatabasecanalsobeusedtocompareanyaminoacidsequencebetweenspeciesandbetweenprotein.ThefullaminoacidsequenceofthetargetproteincanbefoundbyfollowingthelinkintheAccessionfield.YoucanthensearchanyaminoacidsequenceinthetargetproteinusingtheBLASTdatabase.Whenselectingasequencetosearch,pleasechoosecarefully,asthesequenceyouchoosemaybeaprecursorratherthanthematureproteinforexample. |
| Form | Lyophilisedwith5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3 |
| Reconstitution | Reconstitutein100µlofsteriledistilledwatertoachieveanantibodyconcentrationof1mg/ml.Centrifugetoremoveanyinsolublematerial. |
| Storage | Atleast12monthsafterpurchaseat-20°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.ArberD.A.etal.AmJClinPathol.2001;116:25-33 2.KimuraSetal.Proteins1988;3:113-20. 3.WeilS.C.etal.Science1988;240:790-2. 4.LanzaF.JMolMed1998;76:676-81. 5.PinkusG.S.ModPathol1991;4:733-41. 6.GrayE.etal.BrainPathol.2008Jan;18(1):86-95. 7.MakiR.A.etal.JBiolChem.2009Jan30;284(5):3158-69. |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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