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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/绵羊抗rh-BDNF抗体:全血清/S-016-100/100µl
商品详细Biosensis/绵羊抗rh-BDNF抗体:全血清/S-016-100/100µl
Biosensis/绵羊抗rh-BDNF抗体:全血清/S-016-100/100µl
Biosensis/绵羊抗rh-BDNF抗体:全血清/S-016-100/100µl
商品编号: S-016-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionBDNFbelongstotheneurotrophinfamilyandpromotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.ItisamajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"s,andParkinson"sdisease.MicrogliareleaseBDNFthatmaycontributetoneuroinflammationandneuropathicpain.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.POsttranslationmodification:ConvertedintomatureBDNFbyplasmin(PLG).SIMILARITY:BelongstotheNGF-betafamily.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenRecombinanthumanBDNF
OtherNamesBrain-derivedneurotrophicfactor;Abrineurin;proBDNF;
AccessionBDNF_HUMAN
ProducedinSheep
PurityWholeserum
ApplicationsIHC,InhibitionofBIOLOGicalactivityinvitro/invivo.Recommendedtobeusedatadilutionof1:200-2000forimmunohistochemistryonZamboni"sfixedfrozentissue;notrecommendedforformalinfixedparaffinembeddedtissues.1:10to1:50forinhibitionofbiologicalactivityinvitro.Useneatforinvivostudiesat5-10µl/gbodyweight.Wholeserumformatwillcausedimmuneresponses,purifiedformatispreferredformostinvivowork.Notrecommendedforwesternblots.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityAcrossreactivityoflessthan1%againstmouseNGF,recombinanthumanNT3orNT4/5hasbeenshownbyonesiteELISA.
Cross-reactivityThisantiserumrecognisesBDNFfromrat,mouseandhuman.
BlastitIfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
References1.AAchesonetal(1995)Nat.74:450-3
2.QYanetal(1994)J.Neurosci.14(9):5281-91
3.XFZhouetal(1996)Neurosci.74:945-53
4.XFZhou,etal(1998)Exp.Neurol.149:237-42
5.BMellstrometal(2004)CritRevNeurobiol16,43-9
6.ITapia-Arancibiaetal(2004)FrontNeuroendocrinol25,77-107
7.SPezet,etal(2002)BrainResBrainResRev40,240-9
8.JACoulletal(2005)Nature.Dec15;438(7070):1017-21.
9.CGomesetal(2013)JNeuroinflammation.Jan30;10:16.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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