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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/绵羊抗rh-GDNF抗体:亲和纯化/S-021-50/50µg
商品详细Biosensis/绵羊抗rh-GDNF抗体:亲和纯化/S-021-50/50µg
Biosensis/绵羊抗rh-GDNF抗体:亲和纯化/S-021-50/50µg
Biosensis/绵羊抗rh-GDNF抗体:亲和纯化/S-021-50/50µg
商品编号: S-021-50
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionGDNFisaglycosylated,disulfide-bondedhomodimermolecule.ItwasfirstdiscoveredasapotentsurvivalfactorformidbraindopaminergicneuronsandwasthenshowntorescuetheseneuronsinanimalmodelsofParkinson"sdisease.GDNFisabout100timesmoreefficientsurvivalfactorforspinalmotorneuronsthantheneurotrophins.FUNCTION:Neurotrophicfactorthatenhancessurvivalandmorphologicaldifferentiationofdopaminergicneuronsandincreasestheirhigh-affinitydopamineuptake.SUBUNIT:Homodimer;disulfide-linked.SUBCELLULARLOCATION:Secretedprotein.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.DISEASE:DefectsinGDNFmaybeacauseofHirschsprungdisease(HSCR).InassociationwithmutationsofRETgene,defectsinGDNFmaybeinvolvedinHirschsprungdisease.Thisgeneticdisorderofneuralcrestdevelopmentischaracterizedbytheabsenceofintramuralganglioncellsinthehindgut,oftenresultinginintestinalobstruction.DISEASE:DefectsinGDNFareacauseofcongenitalcentralhypoventilationsyndrome(CCHS);alsoknownascongenitalfailureofautonomiccontrolorOndinecurse.CCHSisararedisordercharacterizedbyabnormalcontrolofrespirationintheabsenceofneuromuscularorlungdisease,oranidentifiablebrainstemlesion.AdeficiencyinautonomiccontrolofrespirationresultsininadequateornegligIBLeventilatoryandarousalresponsestohypercapniaandhypoxemia.SIMILARITY:BelongstotheTGF-betafamily.GDNFsubfamily.
BatchNo.Seeproductlabel
Unitsize50µg
AntigenRecombinanthumanGDNF
OtherNamesGlialcellline-derivedneurotrophicfactor;Astrocyte-derivedtrophicfactor;ATF;hGDNF;GDNF
AccessionGDNF_HUMAN
ProducedinSheep
PurityAffinitypurified
ApplicationsIHC,WB.Adilutionof1µg/mlisrecommendedforbothapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityNocrossreactivitywithNTNhasbeenobservedinwesternblotanalysis.
Cross-reactivityThisantibodyisknowntoreactwithhuman,mouseandratGDNF.
BlastitIfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit.
FormLyophilised
ReconstitutionReconstitutein50µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
ReferencesLinetal(1993)Science.260(5111):1130-2
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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