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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to AP-1 complex subunit beta-1 (11-29): whole serum/R-167-100/100 µl
商品详细Biosensis/Rabbit antibody to AP-1 complex subunit beta-1 (11-29): whole serum/R-167-100/100 µl
Biosensis/Rabbit antibody to AP-1 complex subunit beta-1 (11-29): whole serum/R-167-100/100 µl
Biosensis/Rabbit antibody to AP-1 complex subunit beta-1 (11-29): whole serum/R-167-100/100 µl
商品编号: R-167-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:Subunitofclathrin-associatedadaptorproteincomplex1thatplaysaroleinproteinsortinginthelate-Golgi/trans-Golginetwork(TGN)and/orendosomes.TheAPcomplexesmediateboththerecruitmentofclathrintomembranesandtherecognitionofsortingsignalswithinthecytosolictailsoftransmembranecargomolecules.SUBUNIT:Adaptorproteincomplex1(AP-1)isanheterotetramercomposedoftwolargeadaptins(gamma1/AP1G1orgamma2/AP1G2andbeta1A/AP1B1orbeta1B/AP1B1),amediumadaptin(mu1A/AP1M1ormu1B/AP1M2)andasmalladaptin(sigma1A/AP1S1orsigma1B/AP1S2orsigma1C/AP1S3).SUBCELLULARLOCATION:Golgiapparatus.Cytoplasmicvesicle;cytoplasmicvesiclemembrane;peripheralmembraneprotein;cytoplasmicside.Note=ComponentofthecoatsurroundingthecytoplasmicfaceofcoatedvesicleslocatedattheGolgicomplex.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Widelyexpressed.DISEASE:DeletionoftheAP1B1genemayplayaroleinthetumOrigenesisofmeningiomas.SIMILARITY:Belongstotheadaptorcomplexeslargesubunitfamily.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(C-KKGEIFELKAELNSDKKEK)correspondingtotheaminoacids11-29ofhumanAP-1complexsubunitbeta-1conjugatedtodiphtheriatoxinhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromAP-1complexsubunitbeta-1proteininmouse,ratandbovine.
OtherNamesAdapter-relatedproteincomplex1beta-1subunit;Beta-adaptin1;AdaptorproteincomplexAP-1beta-1subunit;GolgiadaptorHA1/AP1adaptinbetasubunit;Clathrinassemblyproteincomplex1betalargechain;AP1B1;ADTB1;BAM22
AccessionAP1B1_HUMAN
AP1B1_MOUSE
AP1B1_RAT
AP1B1_BOVIN
ProducedinRabbit
PurityWholeserum
ApplicationsIHC,WB.Thisantibodyworkssuperblyinimmunohistochemistryonfrozenorparaffinembeddedtissues.Antigenretrievalhasbeenusedintestingbutmaynotbenecessary.Typicalworkingdilutionsforroutineimmunohistochemistryare1:1000to1:5000dependingontissueanddetectionmethod.Forwesternblottingadilutionrangeof1:100to1:10000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThisantibodyhasbeenshowntobespecificforAP-1complexsubunitbeta-1.
Cross-reactivityRatandhuman,otherspecieshavenotyettested.
BlastitIfyouwouldliketousethisproductinanotherspeicesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability.
ExpiryDate12monthsafterpurchase
References1.PeyrardM,etal.Genomics36:112-117(1996).
2.PeyrardM,etal.Hum.Mol.Genet.3:1393-1399(1994).
3.SackstederC.A,etal.Biochemistry45:8009-8022(2006).
4.GuilbaudC,etal.Mamm.Genome8:651-656(1997).
5.KirchhausenT,etal.Proc.Natl.Acad.Sci.U.S.A.86:2612-2616(1989).
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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