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Biosensis/Rabbit antibody to Contactin-6 (993-1011): whole serum/R-127-100/100 µl
Biosensis/Rabbit antibody to Contactin-6 (993-1011): whole serum/R-127-100/100 µl
商品编号：
R-127-100
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | TheneuraladhesionmoleculeContactin-6,alsoknownasNB-3,isacontactin/F3subgroupmemberofimmunoglobulinsuperfamily.Itisexpressedexclusivelyinthenervoussystemandmainlyupregulatedattheearlypostnatalstageduringmousebraindevelopment.EmployingNorthernblotanalysisKameietalfoundthatamongstdifferentregionsoftheadulthumannervoussystemcerebellumexpressedhighestlevelofNB-3mRNA.TheexpressionofNB-3inthecerebellumincreasesuntiladulthood.Incontrast,theexpressioninthecerebrumdeclinestoalowlevelafterpostnatalday7.NB-3likeotherneuralrecognitionmoleculesplaysavitallyimportantroleinaxonalguidanceduringdevelopment,plasticity,andmaintenanceofsynapticconnectionsintheadultbrain.CuietalrecentlyshowedthatNB-3actsasanovelNotchligandtoparticipateinoligodendrocytegeneration.FurThermore,NB-3triggersnucleartranslocationoftheNotchintracellulardomainandpromotesoligodendrogliogenesisfromProgenitorcellsanddifferentiationofoligodendrocyteprecursorcellsviaDeltex1.Inprimaryoligodendrocytes,NB-3increasesmyelin-associatedglycoproteintranscripts.Hence,theNB-3/Notchsignalingpathwaymaybeworthwhileacloserexaminationforitspotentialforthetreatmentofdemyelinatingdiseases.HumanNB-3shareswithratNB-386%identityinnucleotidesequencesand90%identityinaminoacidsequences.FUNCTION:Contactinsmediatecellsurfaceinteractionsduringnervoussystemdevelopment.ParticipatesinoligodendrocytesgenerationbyactingasaligandofNOTCH1.ItsassociationwithNOTCH1promotesNOTCH1activationthroughthereleasednotchintracellulardomain(NICD)andsubsequenttranslocationtothenucleus.Involvedinmotorcoordination.SUBCELLULARLOCATION:Cellmembrane;lipid-anchor;GPI-anchor.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Expressedinbrain.Inbrain,itispreferentiallyexpressedintheaccessoryolfactorybulb,layersII/IIIandVofthecerebralcortex,piriformcortex,anteriorthalamicnuclei,locuscoeruleusoftheponsandmesencephalictrigeminalnucleusandinPurkinjecellsofthecerebellum.DEVELOPMENTALSTAGE:Highlyexpressedafterbirth,reachingamaximumatthepostnatalday7,anddeclinesthereafterinthecerebrum,whereasitincreasesinthecerebellumtoadulthood. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(KLHKMSSLSSVGVQILKPSTQF)aspartofratcontactin-6conjugatedtoKLHhasbeenusedastheimmunogen. |
| OtherNames | NeuralrecognitionmoleculeNB-3;mNB-3 |
| Accession | CNTN6_RAT |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC.Adilutionof1:1000to1:5000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThisantiserumstainsbeautifullytheNB3inDRG,whereitnicelystainsasubpopulationofneuronsandinthetrigeminalnerveroot,wherestainingisrestrictedtotheoligodendrocytes. |
| Cross-reactivity | ConfirmedtoreactwithratContactin-6 |
| Blastit | Ifyouwouldliketousethisproductinanotherspeicesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsatminus20ºCforincreasedstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.Kameietal(1998)JNeurosciRes.51(3):275-83 2.Takedaetal(2003)JNeurobiol.56(3):252-65 3.Leeetal(2000)Gene.245(2):253-66 4.Cuietal(2004)JBiolChem.279(24):25858-65 |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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