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当前位置: 首页 > 产品中心 > monoclonal_antibody > Fox1[共济失调-2结合蛋白1,A2BP1]生物传感器/小鼠单克隆/M-1688-100/100微升
商品详细Fox1[共济失调-2结合蛋白1,A2BP1]生物传感器/小鼠单克隆/M-1688-100/100微升
Fox1[共济失调-2结合蛋白1,A2BP1]生物传感器/小鼠单克隆/M-1688-100/100微升
Fox1[共济失调-2结合蛋白1,A2BP1]生物传感器/小鼠单克隆/M-1688-100/100微升
商品编号: M-1688-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFox1isoneofafamilyof3mammalianFox1homologues.Fox1wasdiscoveredinC.elegansasageneinvolvedinsexdetermination,andthenameFoxisanacronymof"FeminizinglocusonX"(1).TheC.elegansFox1proteinandits3mammalianhomologuesareallabout46kDaproteinsandeachincludesacentralhighlyconservedRRMtypeRNArecognitionmotif,whichcorrespondstoasmall~70aminoacidstructureconsistingof4betastrandsandtwoalpha-helices.ThisregionisidenticalinallthreemammalianFox1familyproteins.AnalternatenameforFox1isataxin-2bindingprotein1(A2BP1),sinceitwasdiscoveredinayeasttwohybridscreenusingataxin-2asbait(2).AswiththeotherFoxproteins,itisassumedthatFox1/A2BP1hasaroleintheRNAsplicinginthenervoussystem(3).Fox3,aproteinalsoknownasNeuN,isawidelyusedMarkerofneuronalnucleiandproximalcytoplasm(4,5).LikeFox3,Fox1isexpressedinneuronalnuclei,butwithadifferentpatternofexpressionthanFox3.Forexample,inthecerebellumFox3doesnotstainPurkinjeneuronsandGolgineurons,butthesetwoneurontypesarestainedbyFox1antibody(6).
BatchNo.Seeviallabel
Unitsize100uL
AntigenN-terminal100aminoacidsofhumanFox1asexpressedinandpurifiedfromE.coli.
AntibodyTypeMonoclonal
IsotypeIgG1
OtherNamesataxin-2bindingprotein1(A2BP1)
ProducedinMouse
ApplicationsImmunocytochemistry(IHC)andWesternBlotting(WB).Adilutionof1:1,000-1:2,000isrecommendedforWB.Adilutionof1:500-1:1000isrecommendedforICC.Theoptimaldilutionshouldbedeterminedbytheenduser.
SpecificityTheantibodyreactswitha48kDaand46kDabandbyWesternblotonextractfrommousebrain.Ithasalsobeenusedsuccessfullyforimmunocytochemistryonratneuronalcultures.
SpeciesAgainstHuman,bovine,mouseandrat.Itisexpectedthatitwillworkonothermammaltissues.
AntibodyAgainstFox1/A2BP1
FormLyophilizedfromPBS.Contains5%trehalose.
AppearanceWhitepowder
ReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionoflyophilizedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
GeneralReferences1.HodgkinJ,ZellanJD,AlbertsonDG.Identificationofacandidateprimarysexdeterminationlocus,fox-1,ontheXchromosomeofCaenorhaBDitiselegans.Development120:3681-3689(1994).2.ShibataH,HuynhDP,PulstSM.AnovelproteinwithRNA-bindingmotifsinteractswithataxin-2.HumMolGenet.39:1303-13(2000).3.UnderwoodJG,BoutzPL,DoughertyJD,StoilovPandBlackDL.HomologuesoftheCaenorhabditiselegansFox-1proteinareneuronalsplicingregulatorsinmammals.Mol.Cell.Biol.25:10005-10016(2005).4.MullenRJ,BuckCR,SmithAM.NeuN,aneuronalspecificnuclearproteininvertebrates.Development116:201-211(1994).5.KimKK,AdelsteinRS,KawamotoS.Identificationofneuronalnuclei(NeuN)asFox-3,anewmemberoftheFox-1genefamilyofsplicingfactors.J.Biol.Chem.284:31052-31061(2009).6.KimKK,KimYC,AdelsteinRS,KawamotoS.Fox-3andPSFinteracttoactivateneuralcell-specificalternativesplicing.NucleicAcidsRes.39:3064-78(2011).
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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