Biosensis/小鼠酪氨酸羟化酶克隆单克隆抗体（LNC 1）/M-1616-100/100µl
商品编号：
M-1616-100
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | TyrosinehydroxylaseisanexcellentMarkerfordopaminergicandnoradrenergicneurons.Tyrosinehydroxylase(a.k.a.tyrosine3-monooxygenase) istheenzymeresponsIBLeforcatalyzingtheconversionoftheaminoacidL-tyrosinetoL-3,4-dihydroxyphenylalanine(L-DOPA).L-DOPAisaprecursorfordopamine,which,inturn,isaprecursorfortheimportantneurotransmittersnorepinephrine(noradrenaline)andepinephrine(adrenaline).Tyrosinehydroxylasecatalyzestheratelimitingstepinthissynthesisofcatecholamines.Inhumans,tyrosinehydroxylaseisencodedbytheTHgene,andtheenzymeispresentinthecentralnervoussystem(CNS),peripheralsymphaticneuronsandtheadrenalmedulla.TheenzymaticactivityofTHrequiresferrousionsascofactorsandisbelievedtoberegulatedbyphosphorylation.AtleastfourisoformsofhumanTHhavebeenidentifiedwhichresultfromalternativesplicing.Tyrosinehydroxylase,phenylalaninehydroxylaseandtryptophanhydroxylasetogethermakeupthefamilyofaromaticaminoacidhydroxylases(AAAHs).http://en.wikipedia.org/wiki/Tyrosine_hydroxylase |
| BatchNo. | seeproductlabel |
| Unitsize | 100µl |
| Antigen | TyrosineHydroxylasepurifiedfromPC12cells |
| AntigenLocation | RecognizesanepitopeontheoutsideoftheregulatoryN-terminus |
| AntibodyType | monoclonal,mouseIgG1kappa |
| Isotype | IgG1,kappa |
| Clone | LNC1;LNC1;LNC-1 |
| OtherNames | LNC-1;LNC1;THmonoclonal |
| Accession | P04177(TY3H_RAT) |
| Producedin | Mouse |
| MolecularWeight | 59-61kDaonreducedwesterns,LNC1recognizesallfourknownisoformsofmammalianTH. |
| Purity | Unpurifiedascitesfluid,dilutedwithPBScontaining3%BSA,nopreservatives. |
| Applications | WesternBlotting(WB),Immunohistochemistry(IH),Immunohistochemistry/paraffinembeddedIH(P),Immunoprecipitation(IP),Immunofluorescence(IF),Flowcytometry(FC).WB:1:1000-1:2000,SDSreducedsamples.Detectsa59-61kDaprotein.RatBrainlysatesisasuitablecontrol.IHC/IH(P):ReactsinformalinfixedparaffinembeddedtissueswithHIERantigenrecovery.Typicaldilutionis1:100-1:200dependinguponincubationtimeanddetectionmethodused.IF:1:200-1:1000,4%PFAfixedtissues/cellspermeABIlizedwith0.1-0.4%tritonX-100;alsoworksinfreshfrozenandacetonefixedtissues/cells.IP:1:100,immobilizedonproteinAbeads,Fleming-Jonesetal(1995)J.ProteinChemistry14(5):275-282.FC:Fixed,permeabilizeddopaminergicnerveterminalsfromratstriatum,{Wolf,ME,Kapatos,G(1989)TheJournalofNeuroscience,January1989,9(l):108-114;WolfME,Zigmond,MJ,Kapatos,G(1989)J.NeuRochemistry53(3):879-885}. |
| Specificity | CloneLNC1recognizesanepitopeontheoutsideoftheregulatoryN-terminus.Theclonedetectsaproteinofapproximately59-61kDabyWesternblotandreducedSDS-PAGE.Theclonedoesnotreactwithdopamine-beta-hydroxylase,phenylalaninehydroxylase,trytophanhydroxylase,dehydropteridinereductase,sepiapterinreductaseorphenethanolamine-N-methyltransferase(PNMT)bywesternblots. |
| AntibodyAgainst | RatTyrosinehydroxylase |
| Cross-reactivity | Chicken,Frog,Horse,Human,Monkey,Mouse,Vole,Sheep,Zebrafishotherspeciesnotyettested |
| Form | Lyophilized,drypowder. |
| Appearance | DryPowder |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°to-70Cforahigherstability.At4°Ckeepuptooneweek,insulated,protectedfromlight;usesterilemethodsandPipettes.Highlypurifiedglycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.Keeptightlyclosedwhennotinuseandprotectedfromlight |
| ExpiryDate | 12monthsfromdateofreceipt |
| SpecificReferences | KapatosG.,KemskiV.,andGeddesT.(1989)Dopamineneuronsinmonolayercultureasamodelsystemforthestudyoftyrosinehydroxylase,inPteridinesandBiogenicAminesinNeuropsychiatry,PediatricsandImmunology(LevineR.A.,KuhnD.M.,MilstienS.,andCurtiusH-C.,eds),pp.243258.LakeshorePublishers,GrossePointe,Michigan. |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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