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Biosensis/Rabbit antibody to Tyrosine Hydroxylase (TH): IgG/R-1645-500/500 µg
Biosensis/Rabbit antibody to Tyrosine Hydroxylase (TH): IgG/R-1645-500/500 µg
商品编号:
R-1645-500
品牌:
Biosensis inc
市场价:
¥5940.00
美元价:
3564.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | Tyrosinehydroxylase(TH)istherate-limitingenzymeinthesynthesisofthecatecholaminesdopamine,epinephrineandnorepinephrine.ThereforetheregulationoftheTHenzymerepresentsthecentralmeansforcontrollingthesynthesisoftheseimportantcatecholamines.FUNCTION:Playsanimportantroleinthephysiologyofadrenergicneurons.CATALYTICACTIVITY:L-tyrosine+tetrahydrobiopterin+O2=3,4-dihydroxy-L-phenylalanine+4a-hydroxytetrahydrobiopterin.COFACTOR:Fe(2+)ion.ENZYMEREGULATION:Phosphorylationleadstoanincreaseinthecatalyticactivity.PATHWAY:Catecholaminebiosynthesis;firststep.SUBUNIT:Homotetramer.PTM:Invitro,phosphorylationofSer-19increasestherateofSer-40phosphorylation,whichresultsinenzymeopeningandactivation.SIMILARITY:Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily.ThepresenceofdifferentDNAsequencesattheTHlocusconferssusceptibilitytovariousdisordersofthebrainincludingmanic-depressionandschizophrenia.Parkinson"sdiseaseisalsoconsideredaTHdeficiencyaslowdopaminelevelsareaconsistentneuRochemicalabnormality. |
Relatedproducts | R-118-100.R-1645-500istheProteinG-purifiedversionofR-118-100(wholeserum). |
BatchNo. | Seeproductlabel |
Unitsize | 500µg |
Antigen | Asyntheticpeptide(PRFIGRRQSLIEDARK)aspartofhumanTyrosineHydroxylase(63-78)conjugatedtoKLHhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromTHproteininrat(31-47). |
OtherNames | TH;Tyrosinehydroxylase;Tyrosine3-monooxygenase;L-tyrosinehydroxylase;Tyrosine3-hydroxylase |
Accession | P04177TY3H_RAT; |
Producedin | Rabbit |
Purity | ProteinGpurified |
Applications | IHC.Aconcentrationof4-10µg/mLisrecommendedforthisapplication.ThisisasuperbantibodyfordetectionoftyrosinehydroxylasecontainingneuronsexhibitinganintenselabellingwithanegligIBLebackground.Thisantiserumhasprovenextremelyusefulforstainingofcatecholaminergicneurons.Itstainsnicelyandintenselydendriticprocessesandfinenerveterminals.Werecommendmouseorratbraincontainingcatecholaminergicneuronsasapositivecontrolforthisantibody,forexamplebrainstemorstriatum.Westernblotting:Aconcentrationof5-15µg/mLisrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | IHConbrainshowsapatternofstainingspecificforTHcontainingneurons. |
Cross-reactivity | Thisantibodyisknowntoreactwithrat,mouseandguineapig.Crossreactivitywithotherspecieshasnotyetbeentested. |
Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
Form | LyophilisedfromPBS,pH7.4,withoutpreservatives. |
Appearance | Whitepowder |
Reconstitution | Reconstitutein500µLofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchaseifunopened. |
SpecificReferences | 1.PierreS.R.,LemmensM.A.,Figueiredo-PereiraM.E.(2009)SubchronicinfusionoftheproductofinflammationprostaglandinJ2modelssporADIcParkinson"sdiseaseinmiceJNeuroinflammation.Jul25;6:18 2.TakeokaA.etal(2010)Noradrenergicinnervationoftheratspinalcordcaudaltoacompletespinalcordtransection:effectsofolfactoryensheathinggliaJExpNeurol.2010Mar;222(1):59-69. 3.BrownR.E.etal(2008)CharacterizationofGABAergicneuronsinrapid-eye-movementsleepcontrollingregionsofthebrainstemreticularformationinGAD67-greenfluorescentproteinknock-inmice.EurJNeurosci.2008Jan;27(2):352-63. 4.BisemNJetal(2012)MappingofFGF1intheMedullaOblongataofMacacafascicularis.ActaHistochemCytochem.2012Dec26;45(6):325-34. |
References | 1.Mallett,J.TrendsinPharmacologicalScience.17(4):129-135,1996. 2.Haavik,J.etal.Mol.NeuroBIOLOGy16(3):285-309,1998. 3.LewisDA,etal,Neuroscience54:477,1993 4.KumerS.C.etal.JournalofNeurochemistry,67(2):443-462,1996. 5.Haycock,J.Anal.Biochemistry181:259-266,1989. 6.Haycock,J.Anal.Biochemistry208:397-399,1993. 7.Renfroe,J.B.,etal.BrainRes.Bull.13:109-126,1984. 8.Xu,Zeta.lNeurosci.82(3):727,1998 |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话:PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话:PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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