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Biosensis/Mouse monoclonal antibody to human p75NTR [ME20.4]: IgG/M-011-100/100 µg
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Biosensis/Mouse monoclonal antibody to human p75NTR [ME20.4]: IgG/M-011-100/100 µg
商品编号：
M-011-100
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | Nervegrowthfactorreceptor(NGFR)isalsoreferredtoasp75(NTR)duetoitsmolecularmassanditsABIlitytobindatlowaffinitynotonlyNGF(see162030),butalsootherneurotrophins,includingbrain-derivedneurotrophicfactor(BDNF;113505),neurotrophin-3(NTF3;162660),andneurotrophin-4/5(NTF5;162662).Atthetimeofitsdiscovery,NGFRwasconsideredauniquetypeofprotein.Subsequently,however,alargesuperfamilyoftumornecrosisfactorreceptorswerefoundtosharetheoverallstructureofNGFR(4extracellularligand-binding,cysteine-richrepeats,orCRs,andsignalingthroughassociationwith,ordisassociationfrom,cytoplasmicinteractors).TheidentificationofthissuperfamilyhelpedelucidatesomeoftheBIOLOGicfunctionsofNGFR,includingitsultimateinvolvementinthenuclearfactorkappa-B(NFKB;see164011)andapoptosispathways.Asamonomer,NGFRbindsNGFwithlowaffinity.Higheraffinitybindingisachievedbyassociationwithhighermolecularmass,low-affinityneurotrophinreceptors,namelythetropomyosinreceptorkinases,TRKA(NTRK1;191315),TRKB(NTRK2;600456),andTRKC(NTRK3;191316).TRKA,TRKB,andTRKCarespecificforor"preferredby"NGF,NTF5andBDNF,andNTF3,respectively(Ipetal.,1993).NTF3alsobindstoTRKAandTRKB,butwithsignificantlyloweraffinity |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Thep75NTRantibodywasderivedfromimmunizationofmicewithhumanWM245melanomacells. |
| Clone | ME20.4 |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;Tumornecrosisfactorreceptorsuperfamilymember16;CD271;NGFR;TNFRSF16; |
| Accession | P08138TNR16_HUMAN; |
| Producedin | Mouse |
| Purity | Immunoglobulin(IgG2A)waspurifiedusingProteinGcolumn(AmershamPharmacia),polishedwithSephacryl200HR(AmershamPharmacia)inPBSandthenlyophilized.Puritywasanalysedusingelectrophoresis,4-12%BisTrisGel(Invitrogen). |
| Applications | Immunohistochemistry,immunofluorescence,flowcytometry.Suggestedworkingdilutions:ForImmunohistochemistryaconcentrationof2µg/mlisrecommended.AntibodynotappropriateforWesternBlot.ForFACSaconcentrationof20µg/mlisrecommended.Atleast1in5000dilutionisrecommendedfor1siteELISAs.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Thisantibodyrecognisesp75NTR(lowaffinityneurotrophinreceptor) |
| Cross-reactivity | Reactswithhuman,cat,dog,pig,rabbitandsheep.Doesnotreactwithratormouse. |
| Form | Lyophilised |
| Reconstitution | Reconstitutewiththeadditionof100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°Cforahigherstability,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| SpecificReferences | 1.LiuW.etal(2012)DistributionofP75neurotrophinreceptorinadulthumancochlea-animmunohistochemicalstudy.CellTissueRes.2012Mar31. 2.InoueK.etal.(2009)Differentialexpressionofstem-cell-associatedMarkersinhumanhairfollicleepithelialcells.LabInvest.2009Aug;89(8):844-56. 3.ArigaM.etal.(2008)Functionalroleofsortilininmyogenesisanddevelopmentofinsulin-responsiveglucosetransportsysteminC2C12myocytesJBiolChem.2008Apr11;283(15):10208-20 4.RogersMLetal(2010)ProNGFmediatesdeathofNaturalKillercellsthroughactivationofthep75NTR-sortilincomplex.JNeuroimmunol.2010Sep14;226(1-2):93-103. 5.Jiaoetal.Differentiationdefectinneuralcrest-derivedsmoothmusclecellsinpatientswithaortopathyassociatedwithbicUSPidaorticvalves.EBioMedicine(2016)10:282-90. |
| References | 1.WalkerBRetal.(2007)BehavBrainRes176:109-20 2.RossA.H.etal.(1984)Characterizationofnervegrowthfactorreceptorinneuralcresttumorsusingmonoclonalantibodies.ProcNatlAcadSciUSA.1984Nov;81(21):6681-5.ORIGINALPAPER |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
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