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Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2] - FITC/M-018-100-FT/100 µg
![Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2] - FITC/M-018-100-FT/100 µg](https://www.ebiomall.cn/images/biosensis/201712/MLR2-Fluorescence-WR.jpg)
Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2] - FITC/M-018-100-FT/100 µg
商品编号：
M-018-100-FT
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | p75NTRwasoriginallydiscoveredasalowaffinitynervegrowthfactorreceptor.Lateritwasfoundthatitwasthereceptorforallneurotrophins.Itmediatessignalsofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.Recently,ithasbeenrevealedthatp75NTRnotonlyactsasthereceptorforneurotrophinsbutalsothereceptorformanyotherpathologicalligandssuchasprions,rABIesvirusandamyloidbeta.p75NTRalsoactsasaco-receptorforNOGOwhichmediatesinhibitorysignalsofmyelinassociatedprotein.p75NTRishighlyexpressedinanumberofnon-neuronalandneuronalcellsincludingmotorneuronsduringdevelopmentandalsoindamagedneurons.FUNCTION:LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithNGFRAP1/BEX3.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1. |
| Relatedproducts | M-1763-100-FT,Non-specificControlIgG,cloneX63(Monoclonal)-FITC |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Humanrecombinantp75 |
| Isotype | IgG2a |
| Clone | MLR2 |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;Tumornecrosisfactorreceptorsuperfamilymember16;CD271;NGFR;TNFRSF16; |
| Accession | P08138TNR16_HUMAN; |
| Producedin | Mouse |
| Purity | Immunoglobulin(IgG2A)waspurifiedusingProteinGcolumn(AmershamPharmacia),polishedwithSephacryl200HR(AmershamPharmacia)inPBS.TheantibodywasthenconjugatedtoFluoresceinisomer1(FITC,Sigma).Aminimumfluorescein:proteinratioof3:1isguaranteed.TheconjugatewaspurifiedviagelfiltrationusingaG25finegraingelin10mMTris/50mMNaClsolution. |
| Applications | Immunofluorescence,flowcytometry.Suggestedworkingdilutions:Forimmunofluorescenceaconcentrationof1-5µg/mlisrecommended.LIGHTfixationisamust,orunfixedworksbest.Epitopeissensitivetofixation.ThisantibodyisnotrecommendedfordenaturingWBapplications.ForFACSaconcentrationof20µg/mlisrecommended.ThisantibodydoesnotblockNeurotrophinbinding.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SpecificitywasdemonstratedbyimmunohistochemistryandFACSanalysis.Immunohistochemicalstainingofmotorneuronsinspinalcordfollowinglesionofsciaticnerveandincholinergicneuronsofthebasalforebraincorrespondingtopublishedliterature. |
| Cross-reactivity | Reactswithhuman,mouseandrat.Otherspecieshavenotyetbeentestedbutitisexpectedthatthisantibodywillbeusefulforthestudyofp75inprimatesandotherspecies. |
| Form | Liquid.Bufferis10mMdisodiumphosphate,1.75mMmonopotassiumphosphate,2.7mMpotassiumchloride,135mMsodiumchloride(PBS),pH7.4.Containsnopreservatives. |
| Storage | Theantibodyconjugatecanbestoredat4ºCforupto4monthswiththeadditionofappropriateantibacterialagent. |
| ExpiryDate | Fourmonthsafterpurchase |
| SpecificReferences | HanYCetal.(2016)DirectReprogrammingofMouseFibroblaststoNeuralStemCellsbySmallMolecules.StemCellsInt.2016;2016:4304916. HanYC&ZhouXF.(2015)Methodofproducingmultipotentstemcells.US20150322405A1(patent). ChacónPJ,ArévaloMA,TébarAR.(2010)NGF-activatedproteintyrosinephosphatase1BmediatesthephosphorylationanddegradationofI-kappa-BalphacoupledtoNF-kappa-Bactivation,therebycontrollingdendritemorphology.MolCellNeurosci.2010Apr;43(4):384-93. WieseS,HerrmannT,DrepperC,JablonkaS,FunkN,KlausmeyerA,RogersML,RushRA&SendtnerM(2009)Isolationandenrichmentofembryonicmousemotoneuronsfromthelumbarspinalcordofindividualmouseembryos.NatProtoc.2010;5(1):31-8. |
| References | 1.RogersML,AtmosukartoI,BerhanuDA,MatusicaD,MacardleP,RushRA(2006).Functionalmonoclonalantibodiestop75neurotrophinreceptorraisedinknockoutmice.NeurosciMethods.158(1)pp.109-120 2.MatusicaD,FenechMP,RogersML,RushRA.(2008)CharacterisationanduseoftheNSC-34celllinerforstudyofnerurotrophinreceptortrafficking.J.Neurosci.Res.86(3)pp.553-65. 3.HuhCY,DanikM,ManseauF,TrudeauLE,WilliamsS.(2008)ChronicexposuretonervegrowthfactorincreasesacetylcholineandglutamatereleasefromcholinergicneuronsoftheratmedialseptumanddiagonalbandofBocaviamechanismsmediatedbup75NTR.J.Neurosci.28(6)pp.1404-9. 4.LagaresA,LiHY,ZhouXF,AvendanoC.(2007)Primarysensoryneuronadditionintheadultrattrigeminalganglion:evidenceforneuralcrestglio-neuronalprecursormaturation.J.Neurosci.27(30)pp.7939-53. |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
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TR-200-BG型
PE-1243-50型
抗体试剂盒
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神经营养因子
糖尿病与肥胖
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电话：PE-1239-5
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2个平板ELISA试剂盒
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M-1249-100号
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S-1759-100号
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BL-003-1000型
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神经内分泌
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PE-1242-2型
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神经递质和酶
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神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
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连接蛋白
TR-300-AG型
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发展
阿尔茨海默氏症/帕金森氏症
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