4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a/M-009-100/100 µg
商品详细Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a/M-009-100/100 µg
Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a/M-009-100/100 µg
Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a/M-009-100/100 µg
商品编号: M-009-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Descriptionp75NTRwasoriginallydiscoveredasalowaffinitynervegrowthfactorreceptor.Lateritwasfoundthatitwasthereceptorforallneurotrophins.Itmediatessignalsofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.Recently,ithasbeenrevealedthatp75NTRnotonlyactsasthereceptorforneurotrophinsbutalsothereceptorformanyotherpathologicalligandssuchasprions,rABIesvirusandamyloidbeta.p75NTRalsoactsasaco-receptorforNOGOwhichmediatesinhibitorysignalsofmyelinassociatedprotein.p75NTRishighlyexpressedinanumberofnon-neuronalandneuronalcellsincludingmotorneuronsduringdevelopmentandalsoindamagedneurons.FUNCTION:LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithNGFRAP1/BEX3.
BatchNo.Seeproductlabel
Unitsize100µg
AntigenThisantibodywasraisedagainstchimericrecombinanthumanp75proteincoupledtoanFcregionofhumanimmunoglobulin.
AntigenLocationExtracellulardomainofhumanp75NTR
AntibodyTypemousemonoclonal
IsotypeIgG2a
CloneMLR2
OtherNamesLow-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR
AccessionP08138TNR16_HUMAN;
ProducedinMouse
PurityProteinGpurifiedimmunoglobulin
ApplicationsIH(fresh,acetonefixedsectionsonly,epitopeisfixationsensitive),Notsuitableinparaffinembeddedtissues.WesternBlot(non-denaturingconditionsonly)andImmunopanning.Aconcentrationof1-5µg/mlisrecommendedforimmunohistochemistry,immunopanningandWB.ThisantibodyisnotrecommendedfordenaturingWBapplications.Aconcentrationof20µg/mlisrecommendedforimmunofluorescenceandFACS.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificitySpecificityhasbeenconfirmedusinganumberoftechniquesasdescribedinthereferencebyRogersetal(2006).Theantibodyrecognizesextracellularp75innativeconfigurations.
SpeciesAgainstantibodyrecognizesp75ECfrommouse,ratandhuman,otherspeciesnotyettested.
AntibodyAgainstoriginalimmunogenwashumanp75extracellulardomain.
Cross-reactivityThisantibodyisknowntoreactwithhuman,mouse,ratandguinea-pigp75NTRprotein.
FormLyophilisedfromPBSpH7.4
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20°Cforahigherstability,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferencesSvadasanR(2016)"TheroleofRNAbindingproteinsinmotoneurondiseases"PhDThesis.Application:Immunopanning.Species:Mouse.

YadavPetal.(2016)"NeurofilamentdepletionimprovesmicrotubuledynamicsviamodulationofStat3/stathminsignaling"ActaNeuropathol.Jul;132(1):93-110.Application:Immunopanning.Species:Mouse.

KlausmeyerAetal.(2015)"Isolationandcultureofspinalcordmotorneurons"CurrProtocCellBiol.Mar;66:1.9.1-1.9.10.Application:Immunopanning.Species:Mouse.

SmithKAetal.(2015)"Characterizationandchangesinneurotrophinreceptorp75-ExpressingmotorneuronsinSOD1(G93A)G1Hmice."JCompNeurol.523(11):1664-82.Application:Invivotrafficking.Species:Mouse.

ShepheardSRetal.(2014)"Theextracellulardomainofneurotrophinreceptorp75asacandidatebioMarkerforamyotrophiclateralsclerosis."PLoSOne.9(1):e87398.Application:IP.Species:Human,mouse.

WiszniakSetal.(2013)"TheubiquitinligaseNedd4regulatescranofacialdevelopmentbypromotingcranialneuralcrestcellsurvivalandstem-celllikeproperties."DevBiol.383(2):186-200.Application:IHC.Species:Mouse.

PanniPetal.(2013)"PhagocytosisofbacteriabyolfactoryensheathingcellsandSchwanncells"NeurosciLett.Feb13.pii:S0304-3940(13)00109-2.Application:Immunopanning.Species:Mouse.

ZhangCetal.(2012)"Suppressionofp75neurotrophinreceptorsurfaceexpressionwithintrabodiesinfluencesBcl-xLmRNAexpressionandneuriteoutgrowthinPC12cells."PLoSOne.7(1):e30684.Application:IF,ELISA,FlowCytometry.Species:Rat.

SelvarajBTetal.(2012)"LocalaxonalfunctionofSTAT3rescuesaxondegenerationinthepmnmodelofmotoneurondisease."JCellBiol.199(3):437-51.Application:Immunopanning.Species:Mouse.

ChacónPJetal.(2010)"NGF-activatedproteintyrosinephosphatase1BmediatesthephosphorylationanddegradationofI-kappa-BalphacoupledtoNF-kappa-Bactivation,therebycontrollingdendritemorphology."MolCellNeurosci.43(4):384-93.Application:IF.Species:Mouse.

RogersMLetal.(2010)"ProNGFmediatesdeathofNaturalKillercellsthroughactivationofthep75NTR-sortilincomplex."JNeuroimmunol.226(1-2):93-103.Application:IF,FlowCytometry.Species:Human.

WieseSetal.(2010)"Isolationandenrichmentofembryonicmousemotoneuronsfromthelumbarspinalcordofindividualmouseembryos."NatProtoc.5(1):31-8.Application:Immunopanning.Species:Mouse.

GorrieCaetal.(2010)"EffectsofhumanOEC-derivedcelltransplantsinrodentspinalcordcontusioninjury."BrainRes.1337:8-20.Application:IF.Species:Human.

DengCetal.(2006)"Survivalandmigrationofhumanandratolfactoryensheathingcellsinintactandinjuredspinalcord."JNeurosciRes.83(7):1201-12.Application:IHC.Species:Rat,human.
ReferencesMatusicaDetal.(2008)CharacterisationanduseoftheNSC-34celllinerforstudyofnerurotrophinreceptortrafficking.J.Neurosci.Res.86(3)pp.553-65.

HuhCYetal.(2008)ChronicexposuretonervegrowthfactorincreasesacetylcholineandglutamatereleasefromcholinergicneuronsoftheratmedialseptumanddiagonalbandofBocaviamechanismsmediatedbup75NTR.J.Neurosci.28(6)pp.1404-9.

LagaresAetal.(2007)Primarysensoryneuronadditionintheadultrattrigeminalganglion:evidenceforneuralcrestglio-neuronalprecursormaturation.J.Neurosci.27(30)pp.7939-53.

RogersMLetal.(2006).Functionalmonoclonalantibodiestop75neurotrophinreceptorraisedinknockoutmice.NeurosciMethods.158(1)pp.109-120
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616