当前位置：
首页
>
产品中心 >
Functional_antibody >
Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a/M-009-100/100 µg
![Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a/M-009-100/100 µg](https://www.ebiomall.cn/images/biosensis/201712/M-009-100_Merged.jpg)
Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a/M-009-100/100 µg
商品编号：
M-009-100
品牌：
Biosensis inc
市场价：
¥5940.00
美元价：
3564.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | p75NTRwasoriginallydiscoveredasalowaffinitynervegrowthfactorreceptor.Lateritwasfoundthatitwasthereceptorforallneurotrophins.Itmediatessignalsofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.Recently,ithasbeenrevealedthatp75NTRnotonlyactsasthereceptorforneurotrophinsbutalsothereceptorformanyotherpathologicalligandssuchasprions,rABIesvirusandamyloidbeta.p75NTRalsoactsasaco-receptorforNOGOwhichmediatesinhibitorysignalsofmyelinassociatedprotein.p75NTRishighlyexpressedinanumberofnon-neuronalandneuronalcellsincludingmotorneuronsduringdevelopmentandalsoindamagedneurons.FUNCTION:LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithNGFRAP1/BEX3. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Thisantibodywasraisedagainstchimericrecombinanthumanp75proteincoupledtoanFcregionofhumanimmunoglobulin. |
| AntigenLocation | Extracellulardomainofhumanp75NTR |
| AntibodyType | mousemonoclonal |
| Isotype | IgG2a |
| Clone | MLR2 |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR |
| Accession | P08138TNR16_HUMAN; |
| Producedin | Mouse |
| Purity | ProteinGpurifiedimmunoglobulin |
| Applications | IH(fresh,acetonefixedsectionsonly,epitopeisfixationsensitive),Notsuitableinparaffinembeddedtissues.WesternBlot(non-denaturingconditionsonly)andImmunopanning.Aconcentrationof1-5µg/mlisrecommendedforimmunohistochemistry,immunopanningandWB.ThisantibodyisnotrecommendedfordenaturingWBapplications.Aconcentrationof20µg/mlisrecommendedforimmunofluorescenceandFACS.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SpecificityhasbeenconfirmedusinganumberoftechniquesasdescribedinthereferencebyRogersetal(2006).Theantibodyrecognizesextracellularp75innativeconfigurations. |
| SpeciesAgainst | antibodyrecognizesp75ECfrommouse,ratandhuman,otherspeciesnotyettested. |
| AntibodyAgainst | originalimmunogenwashumanp75extracellulardomain. |
| Cross-reactivity | Thisantibodyisknowntoreactwithhuman,mouse,ratandguinea-pigp75NTRprotein. |
| Form | LyophilisedfromPBSpH7.4 |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°Cforahigherstability,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | SvadasanR(2016)"TheroleofRNAbindingproteinsinmotoneurondiseases"PhDThesis.Application:Immunopanning.Species:Mouse. YadavPetal.(2016)"NeurofilamentdepletionimprovesmicrotubuledynamicsviamodulationofStat3/stathminsignaling"ActaNeuropathol.Jul;132(1):93-110.Application:Immunopanning.Species:Mouse. KlausmeyerAetal.(2015)"Isolationandcultureofspinalcordmotorneurons"CurrProtocCellBiol.Mar;66:1.9.1-1.9.10.Application:Immunopanning.Species:Mouse. SmithKAetal.(2015)"Characterizationandchangesinneurotrophinreceptorp75-ExpressingmotorneuronsinSOD1(G93A)G1Hmice."JCompNeurol.523(11):1664-82.Application:Invivotrafficking.Species:Mouse. ShepheardSRetal.(2014)"Theextracellulardomainofneurotrophinreceptorp75asacandidatebioMarkerforamyotrophiclateralsclerosis."PLoSOne.9(1):e87398.Application:IP.Species:Human,mouse. WiszniakSetal.(2013)"TheubiquitinligaseNedd4regulatescranofacialdevelopmentbypromotingcranialneuralcrestcellsurvivalandstem-celllikeproperties."DevBiol.383(2):186-200.Application:IHC.Species:Mouse. PanniPetal.(2013)"PhagocytosisofbacteriabyolfactoryensheathingcellsandSchwanncells"NeurosciLett.Feb13.pii:S0304-3940(13)00109-2.Application:Immunopanning.Species:Mouse. ZhangCetal.(2012)"Suppressionofp75neurotrophinreceptorsurfaceexpressionwithintrabodiesinfluencesBcl-xLmRNAexpressionandneuriteoutgrowthinPC12cells."PLoSOne.7(1):e30684.Application:IF,ELISA,FlowCytometry.Species:Rat. SelvarajBTetal.(2012)"LocalaxonalfunctionofSTAT3rescuesaxondegenerationinthepmnmodelofmotoneurondisease."JCellBiol.199(3):437-51.Application:Immunopanning.Species:Mouse. ChacónPJetal.(2010)"NGF-activatedproteintyrosinephosphatase1BmediatesthephosphorylationanddegradationofI-kappa-BalphacoupledtoNF-kappa-Bactivation,therebycontrollingdendritemorphology."MolCellNeurosci.43(4):384-93.Application:IF.Species:Mouse. RogersMLetal.(2010)"ProNGFmediatesdeathofNaturalKillercellsthroughactivationofthep75NTR-sortilincomplex."JNeuroimmunol.226(1-2):93-103.Application:IF,FlowCytometry.Species:Human. WieseSetal.(2010)"Isolationandenrichmentofembryonicmousemotoneuronsfromthelumbarspinalcordofindividualmouseembryos."NatProtoc.5(1):31-8.Application:Immunopanning.Species:Mouse. GorrieCaetal.(2010)"EffectsofhumanOEC-derivedcelltransplantsinrodentspinalcordcontusioninjury."BrainRes.1337:8-20.Application:IF.Species:Human. DengCetal.(2006)"Survivalandmigrationofhumanandratolfactoryensheathingcellsinintactandinjuredspinalcord."JNeurosciRes.83(7):1201-12.Application:IHC.Species:Rat,human. |
| References | MatusicaDetal.(2008)CharacterisationanduseoftheNSC-34celllinerforstudyofnerurotrophinreceptortrafficking.J.Neurosci.Res.86(3)pp.553-65. HuhCYetal.(2008)ChronicexposuretonervegrowthfactorincreasesacetylcholineandglutamatereleasefromcholinergicneuronsoftheratmedialseptumanddiagonalbandofBocaviamechanismsmediatedbup75NTR.J.Neurosci.28(6)pp.1404-9. LagaresAetal.(2007)Primarysensoryneuronadditionintheadultrattrigeminalganglion:evidenceforneuralcrestglio-neuronalprecursormaturation.J.Neurosci.27(30)pp.7939-53. RogersMLetal.(2006).Functionalmonoclonalantibodiestop75neurotrophinreceptorraisedinknockoutmice.NeurosciMethods.158(1)pp.109-120 |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话：PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话：PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
显示分类
联络我们
