4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Mouse monoclonal antibody to rat p75NTR [MC192] - ATTO 488/M-026-50-AT/50 µg (1mg/ml)
商品详细Biosensis/Mouse monoclonal antibody to rat p75NTR [MC192] - ATTO 488/M-026-50-AT/50 µg (1mg/ml)
Biosensis/Mouse monoclonal antibody to rat p75NTR [MC192] - ATTO 488/M-026-50-AT/50 µg (1mg/ml)
Biosensis/Mouse monoclonal antibody to rat p75NTR [MC192] - ATTO 488/M-026-50-AT/50 µg (1mg/ml)
商品编号: M-026-50-AT
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionMonoclonalantibodyMC192againsttheratlowaffinitynervegrowthfactorreceptor(p75NTR)isderivedfromthefusionofSp2/0-Ag14myelomacellswithmouseimmunesplenocytes.MC192monoclonalantibodywasoriginallygeneratedbyChandlersetal.p75NTRwasoriginallydiscoveredasalowaffinitynervegrowthfactorreceptor.Lateritwasfoundthatitwasthereceptorforallneurotrophins.Itmediatessignalsofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.Recently,ithasbeenrevealedthatp75NTRnotonlyactsasthereceptorforneurotrophinsbutalsothereceptorformanyotherpathologicalligandssuchasprions,rABIesvirusandamyloidbeta.p75NTRalsoactsasaco-receptorforNOGOwhichmediatesinhibitorysignalsofmyelinassociatedprotein.p75NTRishighlyexpressedinanumberofnon-neuronalandneuronalcellsincludingmotorneuronsduringdevelopmentandalsoindamagedneurons.MC192hasapotentialuseastheligandforgenedeliveryintop75NTR-expressingratcellsviaareceptor-mediatedmechanism.FUNCTION:LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithNGFRAP1/BEX3.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1(Bysimilarity).
BatchNo.Seeproductlabel
Unitsize50µg(1mg/ml)
AntigenRatp75NTR
IsotypeIgG1
CloneMC192
OtherNamesLow-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR
AccessionTNR16_RAT
ProducedinMouse
PurityImmunoglobulin(IgG1)waspurifiedusingProteinGcolumn(AmershamPharmacia),polishedwithSephacryl200HR(AmershamPharmacia)inPBS.TheIgGwasthenconjugatedtoATTO488(ATTOTEC)andpurifiedviagelfiltrationusingaG25finegraingelin10mMTris/50mMNaClsolution.
ApplicationsIF:liveorlightlyfixedcellsortissues(acetoneor4%PFA):2-5ug/mL.Notsuitableforwesternblots;notsuitableforIHonformalinfixedtissues.FACS(20ug/mL)isrecommended,unfixedcells.
SpecificityMC192recognizestheextracellulardomainoftheneurotrophinreceptorp75NTRinratanddoesnotreactwithhumanormouseNGFR.
SpeciesAgainstRAT
AntibodyAgainstn-octoglucosidestabilizedproteinscontainingp75receptor,whichwereisolatedfromplasmamembranesofPC-12cells(Chandleretal.,1984).
Cross-reactivityReactswithrat.DoesnotreactwithmouseorhumanNGFR
FormLiquid
StorageTheantibodyconjugatecanbestoredat4ºCforupto4monthswiththeadditionofappropriateantibacterialagent.
SpecificReferences1.DaviesA.etal(2010)Thealpha2deltasubunitsofvoltage-gatedcalciumchannelsformGPI-anchoredproteins,aposttranslationalmodificationessentialforfunctionProcNatlAcadSciUSA.Jan26;107(4):1654-9
References1.Chandler,C.E.etal(1984)JBiolChem259,6882-6889
2.LagaresAetal(2007)Jofneurosci27(30),7939-7953
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616