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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to Sortilin (neurotensin receptor 3): whole serum/R-150-100/100 µl
商品详细Biosensis/Rabbit antibody to Sortilin (neurotensin receptor 3): whole serum/R-150-100/100 µl
Biosensis/Rabbit antibody to Sortilin (neurotensin receptor 3): whole serum/R-150-100/100 µl
Biosensis/Rabbit antibody to Sortilin (neurotensin receptor 3): whole serum/R-150-100/100 µl
商品编号: R-150-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:FunctionsasasortingreceptorintheGolgicompartmentandasaclearancereceptoronthecellsurface.RequiredforproteintransportfromtheGolgiapparatustothelysosomesbyapathwaythatisindependentofthemannose-6-phosphatereceptor(M6PR).AlsorequiredforproteintransportfromtheGolgiapparatustotheendosomes.PromotesneuronalapoptosisbymediatingendocytosisoftheproapoptoticprecursorformsofBDNF(proBDNF)andNGFB(proNGFB).Alsoactsasareceptorforneurotensin.MaypromotemineralizationoftheextracellularmatrixduringosteogenicdifferentiationbyscavengingextracellularLPL.ProbablyrequiredinADIpocytesfortheformationofspecializedstoragevesiclescontainingtheglucosetransporterSLC2A4/GLUT4(GLUT4storagevesicles,orGSVs).ThesevesiclesprovideastablepoolofSLC2A4andconferincreasedresponsivenesstoinsulin.MayalsomediatetransportfromtheendoplasmicreticulumtotheGolgi.SUBUNIT:InteractswithLPLandSLC2A4.InteractswiththecytosolicadapterproteinsGGA1andGGA2.Interactswithnumerousligandsincludingthereceptor-associatedproteinLRPAP1/RAP,GM2AandPSAP.FormsacomplexwithNGFRwhichbindsspecificallytotheprecursorformsofNGFB(proNGFB)andBDNF(proBDNF).SUBCELLULARLOCATION:Membrane;single-passtypeImembraneprotein.Localizedtomembranesoftheendoplasmicreticulum,endosomes,Golgistack,lysosomesandnucleus.Asmallfractionoftheproteinisalsolocalizedtotheplasmamembrane.MayalsobefoundinSLC2A4/GLUT4storagevesicles(GSVs)inadipocytes.Localizationtotheplasmamembraneinadipocytesmaybeenhancedbyinsulin.TISSUESPECIFICITY:Expressedathighlevelsinbrain,spinalcord,heart,skeletalmuscle,thyroid,placentaandtestis.Expressedatlowerlevelsinlymphoidorgans,kidney,colonandliver.INDUCTION:Duringosteoblastdifferentiation.DOMAIN:TheN-terminalpropeptidemayfacilitateprecursortransportwithintheGolgistack.IntrachainbindingoftheN-terminalpropeptideandtheextracellulardomainmayalsoinhibitprematureligandbinding.DOMAIN:Theextracellulardomainmaybeshedfollowingproteasecleavageinsomecelltypes.PTM:TheN-terminalpropeptideiscleavedbyfurinandpossIBLyotherhomologousproteases.PTM:Contains8intrachaindisulfidebonds.PTM:N-glycosylated.SIMILARITY:Contains9BNRrepeats.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenExtracellulardomainofglycosylatedhumansortilinproducedinCHOcellswasusedastheimmunogen.
OtherNamesNeurotensinreceptor3;NTR3;NT3;Glycoprotein95;Gp95;100kDaNTreceptor;SORT1;
AccessionSORT_HUMAN
ProducedinRabbit
PurityWholeserum
ApplicationsIHC,1-siteELISA(1:5000dilution).Adilutionof1:1000isrecommendedforIHC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificitySpecificitywasdemonstratedbyimmunohistochemistry.
Cross-reactivityReactswithhuman,ratandmouseSortilin.Otherspeciesnotyettested.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
References1.ChenZY,etal.J.Neurosci.25(26)pp6156-6166.
2.MazellaJ,etal.(2001).CellSignal13pp1-6.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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