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						Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum/R-152-100/100 µl
					
								Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum/R-152-100/100 µl
								
										商品编号:
										R-152-100
									
									
										品牌:
										Biosensis inc
									
									
								
										市场价:
										¥5940.00
									
									
										美元价:
										3564.00
									
								
										产品分类:
										功能性抗体
									
									
										公司分类:
										Functional_antibody
									
								
										联系Q Q:
										3392242852
									
									
										电话号码:
										4000-520-616
									
								
										电子邮箱:
										info@ebiomall.com
									
									商品介绍
						| Description | TrkAisamemberoftheneurotrophictyrosinekinasereceptorfamily.Itisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkAisrequiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).TrkAleadstocelldifferentiationsandmayplayaroleinspecifyingsensoryneuronsubtypes.Ithasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Cellmembrane;single-passtypeImembraneprotein.EndocytosedtotheendosomesupontreatmentofcellswithNGF.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.BothisoformshavesimilarBIOLOGicalproperties.TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells.IsoformTrkA-Iisfoundinnon-neuronaltissues.MutationsinTrkAhavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutalatingbehaviour,mentalretardationandcancer. | 
| BatchNo. | Seeproductlabel | 
| Unitsize | 100µl | 
| Antigen | ExtracellulardomainofglycosylatedhumanTrkAproteinproducedinmammaliancellswasusedastheimmunogen. | 
| OtherNames | Tropomyosin-relatedkinasereceptor;Highaffinitynervegrowthfactorreceptor;Neurotrophictyrosinekinasereceptortype1;TRK1transformingtyrosinekinaseprotein;p140-TrkA;Trk-A;NTRK1;TRK; | 
| Accession | NTRK1_HUMAN | 
| Producedin | Rabbit | 
| Purity | Wholeserum | 
| Applications | IHC(1:1000dilution),WesternBlotting(denaturingandnon-reducingSDS-PAGE,1:1000-1:2500dilution),1-siteELISA(1:5000dilution).Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. | 
| Specificity | Specificitywasdemonstratedbyimmunohistochemistry.Whenusedforimmunohistochemistryinratdorsalrootganglia,stainingisrestrictedtotheknowndistributionofTrkA,thatisinsmall,nociceptiveneurons. | 
| Cross-reactivity | Reactswithhuman,ratandmouseTrkA.Otherspeciesnotyettested. | 
| Form | Lyophilised | 
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. | 
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. | 
| SpecificReferences | KobayashiKetal.(2015)NerveGrowthFactorSignalsasPossIBLePathogenicBioMarkersforPerineuralInvasioninAdenoidCysticCarcinom.OtolaryngolHeadNeckSurg.2015Aug;153(2):218-24.Species:Human.Application:IHC. UrenRTetal.(2014)Anovelroleofsuppressorofcytokinesignaling-2intheregulationofTrkAneurotrophinreceptorbiology.JNeuRochem.2014May;129(4):614-27.Species:Mouse.Application:IF.  | 
| References | 1.ZhangFX,etal.(2005)BrainRes16;1062(1-2)pp.92-100. 2.GearhartDA,etal.(2006)JNeurosciMethods.150(2)pp.159-173.  | 
品牌介绍
						Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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