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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum/R-152-100/100 µl
商品详细Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum/R-152-100/100 µl
Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum/R-152-100/100 µl
Biosensis/Rabbit antibody to the Tyrosine Kinase Receptor A (TrkA): whole serum/R-152-100/100 µl
商品编号: R-152-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionTrkAisamemberoftheneurotrophictyrosinekinasereceptorfamily.Itisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkAisrequiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).TrkAleadstocelldifferentiationsandmayplayaroleinspecifyingsensoryneuronsubtypes.Ithasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Cellmembrane;single-passtypeImembraneprotein.EndocytosedtotheendosomesupontreatmentofcellswithNGF.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.BothisoformshavesimilarBIOLOGicalproperties.TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells.IsoformTrkA-Iisfoundinnon-neuronaltissues.MutationsinTrkAhavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutalatingbehaviour,mentalretardationandcancer.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenExtracellulardomainofglycosylatedhumanTrkAproteinproducedinmammaliancellswasusedastheimmunogen.
OtherNamesTropomyosin-relatedkinasereceptor;Highaffinitynervegrowthfactorreceptor;Neurotrophictyrosinekinasereceptortype1;TRK1transformingtyrosinekinaseprotein;p140-TrkA;Trk-A;NTRK1;TRK;
AccessionNTRK1_HUMAN
ProducedinRabbit
PurityWholeserum
ApplicationsIHC(1:1000dilution),WesternBlotting(denaturingandnon-reducingSDS-PAGE,1:1000-1:2500dilution),1-siteELISA(1:5000dilution).Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificitySpecificitywasdemonstratedbyimmunohistochemistry.Whenusedforimmunohistochemistryinratdorsalrootganglia,stainingisrestrictedtotheknowndistributionofTrkA,thatisinsmall,nociceptiveneurons.
Cross-reactivityReactswithhuman,ratandmouseTrkA.Otherspeciesnotyettested.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
SpecificReferencesKobayashiKetal.(2015)NerveGrowthFactorSignalsasPossIBLePathogenicBioMarkersforPerineuralInvasioninAdenoidCysticCarcinom.OtolaryngolHeadNeckSurg.2015Aug;153(2):218-24.Species:Human.Application:IHC.

UrenRTetal.(2014)Anovelroleofsuppressorofcytokinesignaling-2intheregulationofTrkAneurotrophinreceptorbiology.JNeuRochem.2014May;129(4):614-27.Species:Mouse.Application:IF.
References1.ZhangFX,etal.(2005)BrainRes16;1062(1-2)pp.92-100.
2.GearhartDA,etal.(2006)JNeurosciMethods.150(2)pp.159-173.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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