当前位置:
首页
>
产品中心 >
Functional_antibody >
Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
商品编号:
R-1362-100
品牌:
Biosensis inc
市场价:
¥5940.00
美元价:
3564.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | TrkAisamemberoftheneurotrophictyrosinekinasereceptorfamily.Itisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkAisrequiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).TrkAleadstocelldifferentiationsandmayplayaroleinspecifyingsensoryneuronsubtypes.Ithasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Cellmembrane;single-passtypeImembraneprotein.EndocytosedtotheendosomesupontreatmentofcellswithNGF.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.BothisoformshavesimilarBIOLOGicalproperties.TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells.IsoformTrkA-Iisfoundinnon-neuronaltissues.MutationsinTrkAhavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutalatingbehaviour,mentalretardationandcancer. |
BatchNo. | Seeproductlabel |
Unitsize | 100µg |
Antigen | AsyntheticpeptidecorrespondingtoasequenceinthemiddleregionofhumanTrkA(342-361aa)RHGCLRLNQPTHVNNGNYTL).Thissequenceisidenticaltotherelatedratandmousesequencesaswell. |
Sequence | RHGCLRLNQPTHVNNGNYTL |
AntigenLocation | WithintheIg-likeC2-type2Domainspanningtwoglycosylationsites;epitopelieswithintheextracellularregionoftheprotein(33-423aa)within100aminoacidsofitsentryintothetransmembranedomain(aa424-439)[UniprotP04629(NTRK1_HUMAN) |
AntibodyType | Antiserum |
Isotype | IgG |
OtherNames | Tropomyosin-relatedkinasereceptor,Highaffinitynervegrowthfactorreceptor,Neurotrophictyrosinekinasereceptortype1,TRK1transformingtyrosinekinaseprotein,p140-TrkA,Trk-A,GENENAME:NTRK1,TRK. |
Accession | P04629NTRK1_HUMAN; |
Producedin | Rabbit |
Purity | Affinitypurified |
Applications | WesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanTrkA(isoformTrkA-II)hasapredictedlengthof796aminoacidsandMWof87kDa.Aconcentrationof0.5-1.0µg/mlisrecommendedtodetecttheproteininformalinfixedandparaffinembeddedtissues.Heatmediatedantigenretrievalisrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWBandIHCagainsttheantigen. |
AntibodyAgainst | TyrosineKinaseReceptorA,TrkA |
Cross-reactivity | Human;rat;predictedtoreactwithmouseduetosequencehomology; |
BlastURL | Clickhere |
Form | Lyophilizedwith5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3addedaspreservative |
Appearance | Lyophilizedwhitepowder |
Reconstitution | Reconstitutein100µlofsteriledistilledwatertoachieveanantibodyconcentrationof1mg/ml.Centrifugetoremoveanyinsolublematerial. |
Storage | Atleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
ExpiryDate | 12monthsafterpurchase |
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
品牌分类
TR-200-BG型
PE-1243-50型
抗体试剂盒
PE-1246-5型
TR-100-BG型
S-1754-500型
神经营养因子
糖尿病与肥胖
细胞内贩运
电话:PE-1239-5
神经肽和受体
B-100-PS型
受体和通道分子
2个平板ELISA试剂盒
M-1763-100英尺
TR-200-BGT公司
电话:PE-1239-2
PE-1242-5型
M-1249-100号
神经营养因子受体
细胞周期调节器
S-1759-100号
PE-1606-100型
PE-1762-100型
B-200-PS型
PE-019-100型
PE-1241-5型
PE-003-100
1个平板ELISA试剂盒
BL-003-1000型
PE-1246-2型
感觉神经系统
PE-1253-100型
TR-100-FJ
BL-005-500型
神经内分泌
M-1728-100型
DNA损伤与修复
PE-001-100型
PE-1608-1型
TR-400-AG公司
PE-1243-25
细胞标记
PE-1608-5型
TR-100-FJT
自噬
PE-1242-2型
其他神经元
神经递质和酶
抗氧化酶
神经元标志物
标记抗体
BL-004-500型
PE-019-25
PE-1608-10型
BL-002-1250型
受体体嵌合体
信令与转录
基质和粘附分子
BL-001-1250型
癌症
PE-019-500
干细胞
连接蛋白
TR-300-AG型
细胞凋亡
PE-1252-100型
生长因子
发展
阿尔茨海默氏症/帕金森氏症
显示分类
联络我们