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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
商品详细Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
商品编号: R-1362-100
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionTrkAisamemberoftheneurotrophictyrosinekinasereceptorfamily.Itisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkAisrequiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).TrkAleadstocelldifferentiationsandmayplayaroleinspecifyingsensoryneuronsubtypes.Ithasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Cellmembrane;single-passtypeImembraneprotein.EndocytosedtotheendosomesupontreatmentofcellswithNGF.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.BothisoformshavesimilarBIOLOGicalproperties.TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells.IsoformTrkA-Iisfoundinnon-neuronaltissues.MutationsinTrkAhavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutalatingbehaviour,mentalretardationandcancer.
BatchNo.Seeproductlabel
Unitsize100µg
AntigenAsyntheticpeptidecorrespondingtoasequenceinthemiddleregionofhumanTrkA(342-361aa)RHGCLRLNQPTHVNNGNYTL).Thissequenceisidenticaltotherelatedratandmousesequencesaswell.
SequenceRHGCLRLNQPTHVNNGNYTL
AntigenLocationWithintheIg-likeC2-type2Domainspanningtwoglycosylationsites;epitopelieswithintheextracellularregionoftheprotein(33-423aa)within100aminoacidsofitsentryintothetransmembranedomain(aa424-439)[UniprotP04629(NTRK1_HUMAN)
AntibodyTypeAntiserum
IsotypeIgG
OtherNamesTropomyosin-relatedkinasereceptor,Highaffinitynervegrowthfactorreceptor,Neurotrophictyrosinekinasereceptortype1,TRK1transformingtyrosinekinaseprotein,p140-TrkA,Trk-A,GENENAME:NTRK1,TRK.
AccessionP04629NTRK1_HUMAN;
ProducedinRabbit
PurityAffinitypurified
ApplicationsWesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanTrkA(isoformTrkA-II)hasapredictedlengthof796aminoacidsandMWof87kDa.Aconcentrationof0.5-1.0µg/mlisrecommendedtodetecttheproteininformalinfixedandparaffinembeddedtissues.Heatmediatedantigenretrievalisrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThespecificityofthisantibodyhasbeenconfirmedbyWBandIHCagainsttheantigen.
AntibodyAgainstTyrosineKinaseReceptorA,TrkA
Cross-reactivityHuman;rat;predictedtoreactwithmouseduetosequencehomology;
BlastURLClickhere
FormLyophilizedwith5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3addedaspreservative
AppearanceLyophilizedwhitepowder
ReconstitutionReconstitutein100µlofsteriledistilledwatertoachieveanantibodyconcentrationof1mg/ml.Centrifugetoremoveanyinsolublematerial.
StorageAtleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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