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当前位置: 首页 > 产品中心 > Other_reagents > Biosensis/重组人CNTF/PE-003-100/100µg
商品详细Biosensis/重组人CNTF/PE-003-100/100µg
Biosensis/重组人CNTF/PE-003-100/100µg
Biosensis/重组人CNTF/PE-003-100/100µg
商品编号: PE-003-100
品牌: Biosensis inc
市场价: ¥4740.00
美元价: 2844.00
产地: 美国(厂家直采)
公司:
产品分类: 其他试剂
公司分类: Other_reagents
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionCNTFisasurvivalpromotingfactorfordifferenttypesofneuronsinvitroandinvivo.TheessentialstructuralfeaturesfortheBIOLOGicalfunctionofhumanCNTFwereinvestigatedbyThier,M.etal.Theyshowedthatdeletionof14N-terminaland18C-terminalaminoacidssignificantlyincreasedbioactivitycomparedtowild-typeCNTF.FUNCTION:CNTFisasurvivalfactorforvariousneuronalcelltypes.Seemstopreventthedegenerationofmotoraxonsafteraxotomy.SUBUNIT:Homodimer.SUBCELLULARLOCATION:Cytoplasm.TISSUESPECIFICITY:Nervoussystem.PHARMACEUTICAL:CNTFisbeingtestedunderthenameAxokinebyRegeneronPharmaceuticalsfortreatmentofhumanmotorneurondiseases,suchasamyotrophiclateralsclerosis(ALS).Asitinducessubstantialweightloss,preferentiallyoffatasopposedtoleanbodymass,itisbeingusedforobesitytreatment.SIMILARITY:BelongstotheCNTFfamily.
BatchNo.Seeproductlabel
Unitsize100µg
SequenceHistidine-V5epitopefusedtohumanCNTF(aa:15-200)MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPTLDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVASTDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFAYQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFISSHQTGIPARGSHYIANNKKM
OtherNamesCiliaryNeuroTrophicFactor
AccessionCNTF_HUMAN
ProducedinE.coli
MolecularWeight22.8kDa
Purity95%bySDS-PAGE
Biol.activityIncreasedsurvivalpromotingactivityonneurons
FormLyophilised
ReconstitutionReconstitutethefreeze-driedCNTFproteininthebufferofchoice,forexamplePBS.
StorageAliquotandkeepat-20°Cforlong-termstorage.Forshorttermkeepat4°C.Avoidrepetitivefreeze/thawcycles.
SpecificReferencesWilliamsECetal.(2014)MutantastrocytesdifferentiatedfromRettsyndromepatients-specificiPSCshaveadverseeffectsonwild-typeneurons.HumMolGenet.2014Jun1;23(11):2968-80.
GeneralReferences1.Lin,L.F.etal(1989)Science246,1023-5
2.Stockli,K.A.etal(1991)JCellBiol115,447-59
3.Saggio,I.etal(1995)EmboJ14,3045-54
4.Hermann,D.M.etal(2001)NeurobiolDis8,655-66
5.Thier,M.etal(1995)JNeurosciRes40,826-35
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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