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当前位置: 首页 > 产品中心 > Functional_antibody > Biosensis/Sheep antibody to c-FOS (2-17): affinity purified/S-045-50/50 µg
商品详细Biosensis/Sheep antibody to c-FOS (2-17): affinity purified/S-045-50/50 µg
Biosensis/Sheep antibody to c-FOS (2-17): affinity purified/S-045-50/50 µg
Biosensis/Sheep antibody to c-FOS (2-17): affinity purified/S-045-50/50 µg
商品编号: S-045-50
品牌: Biosensis inc
市场价: ¥5940.00
美元价: 3564.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionFUNCTION:Nuclearphosphoproteinwhichformsatightbutnon-covalentlylinkedcomplexwiththeJUN/AP-1transcriptionfactor.Hasacriticalfunctioninregulatingthedevelopmentofcellsdestinedtoformandmaintaintheskeleton.Itisthoughttohaveanimportantroleinsignaltransduction,cellproliferationanddifferentiation.SUBUNIT:Heterodimer.InteractswithDSIPI;thisinteractioninhibitsthebindingofactiveAP1toitstargetDNA.InteractswithMAFB.SUBCELLULARLOCATION:Nucleus.INDUCTION:C-fosexpressionincreasesuponavarietyofstimuli,includinggrowthfactors,cytokines,neurotransmitters,polypeptidehormones,stressandcellinjury.SIMILARITY:BelongstothebZIPfamily.Fossubfamily.SIMILARITY:Contains1bZIPdomain
BatchNo.Seeproductlabel
Unitsize50µg
AntigenAsyntheticpeptide(MFSGFNADYEASSSRC;aa2-17)conjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromcFosproteinhuman,rat,mouse,hamsterandcat.
OtherNamesProto-oncogeneproteincFOS;c-FOS
AccessionFOS_HUMAN
Q4FDN1_RAT
FOS_MOUSE
Q56UN0_PHOSU
Q5XQC6_FELCA
ProducedinSheep
PurityAffinitypurified
ApplicationsIHonPFAfixed,frozentissues.Notyettestedonformalinfixed,paraffinembeddedtissuebutexpectedtoreact.Affinitypurifiedantibodyisextremelypowerful.Aconcentrationof1-5µg/mlisrecommendedmostuseswithshort(1-8hour)incubations.Ifusingenhancedbrightfieldoramplifieddetectionmethodsdilutionsandlongprimaryantibodyincubationsdilutionswillneedtobeincreasedsubstantiallytoinhibitbackgroundstaining.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.

Notrecommendedforwesternblottingapplications.MousemonoclonalantibodyM-1752-100orrabbitpolyclonalantibodyR-1751-50areexcellentalternativesforwesternblotting.
SpecificityThisantiserumshowsahighlevelofspecificityforcFOSconfirmedbyimmunohostochemistry.
Cross-reactivityThisantiserumisknowntoreactwithrat,rabbitandhamstercFOS.
BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.
FormLyophilised
ReconstitutionReconstitutein50µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageStorelyophilizedproductat2-8C.Afterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
References1.VanstrAATenetal(1983)Proc.Natl.Acad.Sci.80:3183
2.MinsonJetal.(1994)DisinhibitionoftherostralventralmedullaincreasesbloodpressureandFosexpressioninbulbospinalneurons.BrainRes.1994May16;646(1):44-52.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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