Biosensis/CE Marked BDNF Rapid ELISA Kit: Human (1 plate)/BEK-2211-1P-CE/1 Ea-免疫在线蚂蚁淘旗下平台

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Description	TheBiosensisCEMarkedBDNFRapidenzyme-linkedimmunosorbentassay(ELISA)KitisasandwichELISAthatallowsthepreferentialquantificationofmatureBDNFinlessthan3hours.Thiskitconsistsofapre-coatedmousemonoclonalanti-BDNFcaptureantibody,abiotinylatedanti-BDNFdetectionantibodyandhorserADIshperoxidase(HRP)-conjugatedstreptavidin.Theadditionofasubstrate(3,3,5,5-tetramethylbenzidine,TMB)yieldsacoloredreactionproductwhichisdirectlyproportionaltotheconcentrationofBDNFpresentinsamplesandproteinstandards.ThisBDNFELISAkitemploysarecombinanthumanBDNFstandardapprovedbytheWorldHealthOrganization(WHO,www.NIBSC.org).ThiskitissuitabletomeasurematureBDNFinhumanserumandcitrate-treatedplasmasamplesonly.TheantibodiesusedinthisELISAkitbindepitopeswithinthematuredomainoftheproteinandthereforerecognizethematureaswellasthepro-formofBDNF.However,cross-reactivitytothefull-lengthproBDNFproteinislow. ThisCEMarkedBDNFRapidELISA[Cat.No.BEK-2211-1P-CE]Kitisapprovedforin-vitrodiagnostic(IVD)applicationsintheEuropeanEconomicArea(EEA).IthasbeendevelopedbyBiosensisandismanufacturedbyCalbiotechInc.(www.calbiotech.com)forBiosensis. BEK-2211-1P-CEisnotapprovedforin-vitrodiagnostic(IVD)applicationsintheUnitedStates.Forresearchonhumanblood,customersMUSTorderthecatalognumberBEK-2211-1P.Thisresearch-use-onlyELISAkitcanbeusedforhumanandanimalresearchpurposesworldwide,andhasbeenvalidatedforawiderrangeofsampletypesandspecies.
BatchNo.	Refertotheproductlabel.
Antigen	BDNFbelongstotheneurotrophinfamilyandregulatesthesurvivalanddifferentiationofneuronsduringdevelopment.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"sDisease,andParkinson"sdisease.FUNCTION:BDNFpromotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.BDNFisalsoamajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.PostTranslationModification(PTM):ThepropeptideisN-glycosylatedandglycosulfated.PTM:ConvertedintomatureBDNFbyplasmin(PLG).DISEASE:DefectsinBDNFareacauseofcongenitalcentralhypoventilationsyndrome(CCHS);alsoknownascongenitalfailureofautonomiccontrolorOndinecurse.CCHSisararedisordercharacterizedbyabnormalcontrolofrespirationintheabsenceofneuromuscularorlungdisease,oranidentifiablebrainstemlesion.AdeficiencyinautonomiccontrolofrespirationresultsininadequateornegligIBLeventilatoryandarousalresponsestohypercapniaandhypoxemia.CCHSisfrequentlycomplicatedwithneurocristopathiessuchasHirschsprungdiseasethatoccursinabout16%ofCCHScases.SIMILARITY:BelongstotheNGF-betafamily.
AntigenLength	RecombinanthumanmatureBDNF,expressedandpurifiedfromE.coli.
OtherNames	Brain-derivedneurotrophicfactor;BDNF;Abrineurin
Accession	P23560BDNF_HUMAN;
Applications	BEK-2211-1P-CEisexpresslydesignedandtestedonlyforuseonhumanbloodandplasmasamples.Anyotheruseisdeemed"offlabeluse"andthustheperformancecharacteristicsoftheassaywillhavetobedeterminedbytheenduser,andsuchresultsarenotsupportedbyBiosensisorCalBioTechatthistime.
Specificity	Human.
Storage	Storeat2-8°C
ExpiryDate	SeeBEK-2211-1P-CEprotocolinsertforspecificexpirationdatingofthekitanditscomponents.
Kitcomponents	TheELISAkitboxcontains1x96pre-coatedstripplate,proteinstandards,detectionreagents,washandsamplebuffersanddetailedprotocols.
Range	7.8pg/mL-500pg/mL
Sensitivity	Typicallimitofdetection(LOD)forBDNFis< 3 pg/mL determined by calculating the mean + 2x standard deviation of mean of blank (n=20).
Kitprotocol	BEK-2211-CE-1P_as_at_Nov2016.pdf
MSDS	SDS-BEK-2211-CE_as_at_Dec2016.pdf