Biosensis/人BDNF ELISA试剂盒（1板）/BEK-2002-1P/1 Ea-免疫在线蚂蚁淘旗下平台

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Description	TryournewBDNFRapidELISAkit(BEK-2211-1P).Samespecificityandsensitivity,butfaster! ThehumanBDNFKitisasandwichELISA.ThecaptureantibodyisamonoclonalBDNFantibodypre-coatedontothe96-wellstripplatesprovidedinthekit.HumantestsamplesandstandardsofknownBDNFconcentrationareaddedtothesewellsandallowedtocomplexwiththeboundBNDFantibody.AbiotinylatedBDNFantibodyisthenadded.Thisdetectionantibodybindstotheantigenthuscompletingthesandwich.Afterwashing,anenzymeAvidin-Biotin-Peroxidasecomplex(ABC)isaddedwhichbindstothesecondantibody.TheperoxidasesubstrateTMBisaddedtoinduceacolouredreactionproduct.TheintensityofthiscolouredproductisdirectlyproportionaltotheconcentrationofBDNFpresentinthesamples.Thepurposeofthiskitisthein-vitroquantitativedeterminationofhumanBDNFinsamplessuchassera,plasmaandcellculturesupernates.Thiskithasbeenconfiguredforresearchuseonlyandisnottobeusedindiagnosticorclinicalprocedures.
BatchNo.	Seeproductlabels
Antigen	BDNFbelongstotheneurotrophinfamilyandregulatesthesurvivalanddifferentiationofneuronsduringdevelopment.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"s,andParkinson"sdisease.FUNCTION:Promotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.MajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.PostTranslationModification(PTM):ThepropeptideisN-glycosylatedandglycosulfated.PTM:ConvertedintomatureBDNFbyplasmin(PLG)(Bysimilarity).DISEASE:DefectsinBDNFareacauseofcongenitalcentralhypoventilationsyndrome(CCHS);alsoknownascongenitalfailureofautonomiccontrolorOndinecurse.CCHSisararedisordercharacterizedbyabnormalcontrolofrespirationintheabsenceofneuromuscularorlungdisease,oranidentifiablebrainstemlesion.AdeficiencyinautonomiccontrolofrespirationresultsininadequateornegligIBLeventilatoryandarousalresponsestohypercapniaandhypoxemia.CCHSisfrequentlycomplicatedwithneurocristopathiessuchasHirschsprungdiseasethatoccursinabout16%ofCCHScases.SIMILARITY:BelongstotheNGF-betafamily.
OtherNames	Brain-derivedneurotrophicfactor;BDNF;Abrineurin
Accession	P23560BDNF_HUMAN;
Producedin	ThestandardandimmunogenforthiskitisrecombinantBDNFproducedinandpurifiedfromaninsectcell(sf21)expressionsystem.Thisproteinsequenceisidenticalinhuman,mouse,rat,andmanyotherspecies.
Specificity	Human;Mouse;Rat;
Storage	Storeat4øC
SpecificReferences	MorichiS.etal(2016)ExaminationofneurologicalprognosticMarkersinpatientswithrespiratorysyncytialvirus-associatedencephalopathy.IntJNeurosci.2016Feb;1:1-6 MorichiS.etal(2014)Brain-derivedneurotrophicfactorandinterleukin-6levelsintheserumandcerebrospinalfluidofchildrenwithviralinfection-inducedencephalopathy.NeuRochemRes.2014Nov;39(11):2143-9. ValvassoriSS.etal(2014)Sodiumbutyratefunctionsasanantidepressantandimprovescognitionwithenhancedneurotrophicexpressioninmodelsofmaternaldeprivationandchronicmildstress.CurrNeurovascRes.2014;11(4):359-66. Khan,ZarghonaA(2012)Ph.DThesis,BiochemicalMarkersasEvidenceoftheEffectsofEnvironmentalEnrichmentonPhysiologicalProcessesinHuntingtonsDiseasePatients,EdithCowanUniversity,WesternAustralia. MorichiS.etal(2012)Expressionsofbrain-derivedneurotrophicfactor(BDNF)incerebrospinalfluidandplasmaofchildrenwithmeningitisandencephalitis/encephalopathy.IntJNeurosci.2012Aug20
Kitcomponents	TheELISAkitboxcontains1x96pre-coatedstripplates,proteinstandards,detectionreagents,substratebufferandpreciseinstructions.
Range	31.2pg/ml-2,000pg/ml
Sensitivity	< 15 pg/ml
Kitprotocol	BEK-2002-1P_as_at_Jan2017_protocol.pdf