Biosensis/Rat BDNF ELISA Kit (1 plate)/BEK-2000-1P/1 Ea-免疫在线蚂蚁淘旗下平台

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Description	TryournewBDNFRapidELISAkit(BEK-2211-1P).Samespecificityandsensitivity,butfaster! TheratBDNFKitisasandwichELISA.ThecaptureantibodyisamonoclonalBDNFantibodypre-coatedontothe96-wellstripplatesprovidedinthekit.RattestsamplesandstandardsofknownBDNFconcentrationareaddedtothesewellsandallowedtocomplexwiththeboundBNDFantibody.AbiotinylatedBDNFantibodyisthenadded.Thisdetectionantibodybindstotheantigenthuscompletingthesandwich.Afterwashing,anenzymeAvidin-Biotin-Peroxidasecomplex(ABC)isaddedwhichbindstothesecondantibody.TheperoxidasesubstrateTMBisaddedtoinduceacolouredreactionproduct.TheintensityofthiscolouredproductisdirectlyproportionaltotheconcentrationofBDNFpresentinthesamples.Thepurposeofthiskitisthein-vitroquantitativedeterminationofratBDNFinsamplessuchassera,plasma,celllysatesandcellculturesupernates.Thiskithasbeenconfiguredforresearchuseonlyandisnottobeusedindiagnosticorclinicalprocedures.
BatchNo.	Seeproductlabels
Antigen	BDNFbelongstotheneurotrophinfamilyandregulatesthesurvivalanddifferentiationofneuronsduringdevelopment.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"s,andParkinson"sdisease.FUNCTION:Promotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.MajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.PostTranslationModification(PTM):ThepropeptideisN-glycosylatedandglycosulfated.PTM:ConvertedintomatureBDNFbyplasmin(PLG)(Bysimilarity).DISEASE:DefectsinBDNFareacauseofcongenitalcentralhypoventilationsyndrome(CCHS);alsoknownascongenitalfailureofautonomiccontrolorOndinecurse.CCHSisararedisordercharacterizedbyabnormalcontrolofrespirationintheabsenceofneuromuscularorlungdisease,oranidentifiablebrainstemlesion.AdeficiencyinautonomiccontrolofrespirationresultsininadequateornegligIBLeventilatoryandarousalresponsestohypercapniaandhypoxemia.CCHSisfrequentlycomplicatedwithneurocristopathiessuchasHirschsprungdiseasethatoccursinabout16%ofCCHScases.SIMILARITY:BelongstotheNGF-betafamily.
OtherNames	Brain-derivedneurotrophicfactor;BDNF;Abrineurin
Accession	P23363BDNF_RAT;
Producedin	ThestandardandimmunogenforthiskitisrecombinantBDNFproducedinandpurifiedfromaninsectcell(sf21)expressionsystem.Thisproteinsequenceisidenticalinhuman,mouse,rat,andmanyotherspecies.
Specificity	Human;Mouse;Rat;
Storage	Storeat4øC
Kitcomponents	TheELISAkitboxcontains1x96pre-coatedstripplates,proteinstandards,detectionreagents,substratebufferandpreciseinstructions.
Range	31.2pg/ml-2,000pg/ml
Sensitivity	< 2pg/ml
Kitprotocol	BEK-2000-1P_as_at_Mar2015_protocol.pdf