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当前位置: 首页 > 产品中心 > Receptors > 人神经生长因子(Fc-222/g)在哺乳动物细胞中表达的氨基酸
商品详细人神经生长因子(Fc-222/g)在哺乳动物细胞中表达的氨基酸
人神经生长因子(Fc-222/g)在哺乳动物细胞中表达的氨基酸
人神经生长因子(Fc-222/g)在哺乳动物细胞中表达的氨基酸
商品编号: PE-1238-25
品牌: Biosensis inc
市场价: ¥4340.00
美元价: 2604.00
产地: 美国(厂家直采)
公司:
产品分类: 受体
公司分类: Receptors
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionNervegrowthfactor(NGF)receptor,alsoknownasp75NTR, isalowaffinityNGFreceptor.ItbindswithequalaffinityneurotrophinssuchasbetaNGF,BDNF,NT-3andNT-4.NGFreceptorsmediatesignalingofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.ThesereceptorsarealsothoughttoplayaroleinneurogenerativediseasessuchasAlzheimersdisease.TheNGFreceptorisatypeItransmembraneglycoprotein(399aa)consistingofasignalpeptide(28aa),anextracellulardomain(222aa)whichcontainsfourcysteinerichdomainsresponsIBLeforligandbinding,atransmembranedomain(22aa)andacytoplasmicdomain(155aa).
BatchNo.Seeproductlabel
Unitsize25µg
OtherNamesLow-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;p75NTR;CD271;
AccessionP08138TNR16_HUMAN;
ProducedinHuman-ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanNGFreceptor(aminoacids1-250)wasfusedtotheFcregionofhumanIgG1(aminoacids93-330).Thechimericproteinwasexpressedinmodifiedhuman293cells.
MolecularWeightTheNGFReceptor-Fcchimeramigratesasabroadbandbetween75and100kDainSDS-PAGEduetopost-translationmodifications,inparticularglycosylation.TheunmodifiedNGFReceptor-Fcchimerahasapredictedmassofof50.8kDa.TheNGFReceptor-FcchimeraseparatesintoanumberofisoformswithapIbetween4.0and6.0in2DPAGE.TheunmodifiedNGFReceptor-FcchimerahasapredictedpIof4.89.
Purity>95%,asdeterminedbySDS-PAGEandvisualizedbysilverstain
Biol.activityTheED50oftheNGFReceptor-Fcchimeraistypically0.7-1.0ug/mlasmeasuredbyitsABIlitytoneutralizebetaNGFmediatedproliferationofthehumangrowth-factordependentTF-1cellline.
FormTheNGFReceptor-Fcchimeraconsistsof30-50%carbohydratebyweight.Whenreconstitutedin0.5mlsterilephosphate-bufferedsaline,thesolutionwillcontain1%humanserumalbumin(HSA)and10%trehalose.
ReconstitutionItisrecommendedthat0.5mlofsterilephosphate-bufferedsalinebeaddedtothevial.
StorageLyophilizedproductsshouldbestoredat2to8°C.Followingreconstitutionshort-termstorageat4°Cisrecommended,andlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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