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当前位置: 首页 > 产品中心 > Receptors > Biosensis/哺乳动物细胞中表达的小鼠p75NTR神经生长因子受体Fc嵌合体/PE-1704-25/25µg
商品详细Biosensis/哺乳动物细胞中表达的小鼠p75NTR神经生长因子受体Fc嵌合体/PE-1704-25/25µg
Biosensis/哺乳动物细胞中表达的小鼠p75NTR神经生长因子受体Fc嵌合体/PE-1704-25/25µg
Biosensis/哺乳动物细胞中表达的小鼠p75NTR神经生长因子受体Fc嵌合体/PE-1704-25/25µg
商品编号: PE-1704-25
品牌: Biosensis inc
市场价: ¥4340.00
美元价: 2604.00
产地: 美国(厂家直采)
公司:
产品分类: 受体
公司分类: Receptors
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
DescriptionNervegrowthfactor(NGF)receptor,alsoknownasp75NTR,isalowaffinityNGFreceptor.ItbindswithequalaffinityallmembersoftheneurotrophinfamilyincludingbetaNGF,BDNF,NT-3andNT-4/5.Italsobindsthepro-neurotrophins.NGFreceptorsmediatesignalingofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.ThesereceptorsarealsothoughttoplayaroleinneurogenerativediseasessuchasAlzheimersdisease.Thep75NTRNGFreceptorisatypeItransmembraneglycoprotein(396aa)consistingofasignalpeptide(21aa),anextracellulardomain(225aa)whichcontainsfourcysteinerichdomainsresponsIBLeforligandbinding,atransmembranedomain(19aa)andacytoplasmicdomain(152aa).ItisamemberoftheTNF-alphareceptorfamily(TNR16).Recently,p75NTRhasbeenshowntoactasareceptorformanypathogenssuchasprions,rABIesvirusandamyloidbeta.Italsoactsasaco-receptorforNOGO,mediatinginhibitorysignalsofmyelinassociatedprotein.
BatchNo.Seeproductlabel
Unitsize25µg
OtherNamesLow-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;p75NTR;CD271;FastNGFreceptor.
AccessionQ9Z0W1TNR16_MOUSE;
ProducedinMammalian(CHO)cells.ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanNGFreceptor(aminoacids1-224)wasfusedtotheFcregionofhumanIgG1(aminoacids104-330).ThechimericproteinwasexpressedinmodifiedCHOcells.Thefullsequenceisavailableonrequestfrombiospeak@Biosensis.com.
MolecularWeightTheNGFReceptor-Fcchimeramigratesasabroadbandbetween65and115kDainSDS-PAGEduetopost-translationalmodifications,inparticularglycosylation.TheunmodifiedNGFReceptor-Fcchimerahasapredictedmassof49.7kDa.TheunmodifiedNGFReceptor-FcchimerahasapredictedpIof4.92.
Purity>95%,asdeterminedbySDS-PAGE.
FormFreeze-dried.
ReconstitutionItisrecommendedthat0.25mlofsterilephosphate-bufferedsaline(PBS)beaddedtothevial.
StorageLyophilizedproductsshouldbestoredat2-8°C.Followingreconstitution,short-termstorageat4°Cisrecommendedandlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended.
品牌介绍
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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